Diagnosis and Treatment of Benign Paroxysmal Positional Vertigo
https://jamanetwork.com/journals/jama/fullarticle/2848127
This JAMA Insights discusses the epidemiology, clinical presentation, and diagnostic evaluation of benign paroxysmal positional vertigo.
https://jamanetwork.com/journals/jama/fullarticle/2848127
This JAMA Insights discusses the epidemiology, clinical presentation, and diagnostic evaluation of benign paroxysmal positional vertigo.
Hospital at Home and Transforming US Health Care Delivery
https://jamanetwork.com/journals/jama/fullarticle/2848118
This Viewpoint discusses how programs from the COVID-19 pandemic, including Acute Hospital Care at Home, have created the infrastructure to widely deliver hospital at home care, which could transform US health care delivery in the future.
https://jamanetwork.com/journals/jama/fullarticle/2848118
This Viewpoint discusses how programs from the COVID-19 pandemic, including Acute Hospital Care at Home, have created the infrastructure to widely deliver hospital at home care, which could transform US health care delivery in the future.
Lives Inside of Boxes
https://jamanetwork.com/journals/jama/fullarticle/2848119
In this narrative medicine essay, a retired family physician muses over the predigital tools he collected to help him meet his patients’ health challenges and reflects on how much medicine was integrated into his own life.
https://jamanetwork.com/journals/jama/fullarticle/2848119
In this narrative medicine essay, a retired family physician muses over the predigital tools he collected to help him meet his patients’ health challenges and reflects on how much medicine was integrated into his own life.
Age-Adjusted D-Dimer Cutoff Levels to Exclude Deep Vein Thrombosis
https://jamanetwork.com/journals/jama/fullarticle/2848125
To the Editor Age-adjusted thresholds are used to improve the diagnostic yield of D-dimer testing in suspected pulmonary embolism, but prospective management data in suspected deep vein thrombosis (DVT) have been limited. In a recent study reported by Le Gal and colleagues, the primary outcome focused on patients with D-dimer values between the conventional cutoff and their age-adjusted cutoff. Use of the age-adjusted cutoff increased the proportion of negative D-dimer results from 24.5% to 31.9% by identifying 161 additional patients with D-dimer values between 500 µg/L and their age-adjusted threshold.
https://jamanetwork.com/journals/jama/fullarticle/2848125
To the Editor Age-adjusted thresholds are used to improve the diagnostic yield of D-dimer testing in suspected pulmonary embolism, but prospective management data in suspected deep vein thrombosis (DVT) have been limited. In a recent study reported by Le Gal and colleagues, the primary outcome focused on patients with D-dimer values between the conventional cutoff and their age-adjusted cutoff. Use of the age-adjusted cutoff increased the proportion of negative D-dimer results from 24.5% to 31.9% by identifying 161 additional patients with D-dimer values between 500 µg/L and their age-adjusted threshold.
Monthly Insulin Price Cap for Private Insurance Proposed
https://jamanetwork.com/journals/jama/fullarticle/2848366
A new bill would cap US insulin costs under private insurance.
https://jamanetwork.com/journals/jama/fullarticle/2848366
A new bill would cap US insulin costs under private insurance.
Audio Highlights April 24, 2026
https://jamanetwork.com/journals/jama/fullarticle/2848410
Listen to the JAMA Editor’s Summary for an overview and discussion of the important articles appearing in JAMA.
https://jamanetwork.com/journals/jama/fullarticle/2848410
Listen to the JAMA Editor’s Summary for an overview and discussion of the important articles appearing in JAMA.
AHA Advises Shifting From Meat to Plants
https://jamanetwork.com/journals/jama/fullarticle/2848359
This Medical News article discusses the American Heart Association’s new scientific statement on dietary guidance to improve cardiovascular health.
https://jamanetwork.com/journals/jama/fullarticle/2848359
This Medical News article discusses the American Heart Association’s new scientific statement on dietary guidance to improve cardiovascular health.
Antidepressant May Reduce Methamphetamine Use
https://jamanetwork.com/journals/jama/fullarticle/2848360
This Medical News article discusses the potential for the antidepressant mirtazapine to treat methamphetamine use disorder.
https://jamanetwork.com/journals/jama/fullarticle/2848360
This Medical News article discusses the potential for the antidepressant mirtazapine to treat methamphetamine use disorder.
Alteplase Thrombolysis After Successful Thrombectomy for AIS
https://jamanetwork.com/journals/jamaneurology/fullarticle/2848386
This randomized clinical trial investigates if intra-arterial alteplase improves clinical outcomes in patients with acute ischemic stroke (AIS) of the posterior circulation within 24 hours of symptom onset and after successful mechanical recanalization.
https://jamanetwork.com/journals/jamaneurology/fullarticle/2848386
This randomized clinical trial investigates if intra-arterial alteplase improves clinical outcomes in patients with acute ischemic stroke (AIS) of the posterior circulation within 24 hours of symptom onset and after successful mechanical recanalization.
As-Needed Medications in Newborn Opioid Withdrawal
https://jamanetwork.com/journals/jama/fullarticle/2848413
Neonatal opioid withdrawal syndrome (NOWS) remains a consequential downstream effect of the ongoing opioid epidemic in the US. Although we have improved both access and approach to medical management of opioid use disorder in pregnancy, exposure confers a risk of withdrawal to the infant, regardless of type of exposure or presence of medical supervision. Infants with opioid withdrawal syndrome continue to experience prolonged hospitalization, separation from caregivers, and significant additional opioid exposure. The burden is substantial: tens of thousands of infants are affected annually, and hospitalizations for NOWS continue to consume significant health care resources. Dozens of publications have addressed which medications should be used in the management of NOWS, but there remains a surprising dearth of comparative evidence informing how these medications should be implemented.
https://jamanetwork.com/journals/jama/fullarticle/2848413
Neonatal opioid withdrawal syndrome (NOWS) remains a consequential downstream effect of the ongoing opioid epidemic in the US. Although we have improved both access and approach to medical management of opioid use disorder in pregnancy, exposure confers a risk of withdrawal to the infant, regardless of type of exposure or presence of medical supervision. Infants with opioid withdrawal syndrome continue to experience prolonged hospitalization, separation from caregivers, and significant additional opioid exposure. The burden is substantial: tens of thousands of infants are affected annually, and hospitalizations for NOWS continue to consume significant health care resources. Dozens of publications have addressed which medications should be used in the management of NOWS, but there remains a surprising dearth of comparative evidence informing how these medications should be implemented.
Symptom-Based Dosing for Neonatal Opioid Withdrawal
https://jamanetwork.com/journals/jama/fullarticle/2848412
This crossover randomized clinical trial examines the effect of symptom-based dosing vs scheduled opioid taper on time to medical readiness for discharge in infants with neonatal opioid withdrawal syndrome treated with the Eat, Sleep, Console approach.
https://jamanetwork.com/journals/jama/fullarticle/2848412
This crossover randomized clinical trial examines the effect of symptom-based dosing vs scheduled opioid taper on time to medical readiness for discharge in infants with neonatal opioid withdrawal syndrome treated with the Eat, Sleep, Console approach.
Symptom-Based Dosing for Neonatal Opioid Withdrawal Research Summary
https://jamanetwork.com/journals/jama/fullarticle/2848411
This study assessed whether a symptom-based dosing strategy for opioid treatment reduces time to medical readiness for discharge compared with scheduled opioid taper in infants with neonatal opioid withdrawal syndrome (NOWS) cared for with the Eat, Sleep, Console approach (ESC) or Finnegan-based care, which focuses on detailed scoring of the signs of withdrawal.
https://jamanetwork.com/journals/jama/fullarticle/2848411
This study assessed whether a symptom-based dosing strategy for opioid treatment reduces time to medical readiness for discharge compared with scheduled opioid taper in infants with neonatal opioid withdrawal syndrome (NOWS) cared for with the Eat, Sleep, Console approach (ESC) or Finnegan-based care, which focuses on detailed scoring of the signs of withdrawal.
Review of Cardiac Resynchronization Therapy
https://jamanetwork.com/journals/jama/fullarticle/2848323
This narrative review examines the efficacy of cardiac resynchronization therapy, including biventricular pacing and conduction system pacing, in patients with cardiac dyssynchrony due to conduction system disease.
https://jamanetwork.com/journals/jama/fullarticle/2848323
This narrative review examines the efficacy of cardiac resynchronization therapy, including biventricular pacing and conduction system pacing, in patients with cardiac dyssynchrony due to conduction system disease.
Six-Month Outcomes of a Trial of Potassium Supplementation Thresholds After Cardiac Surgery
https://jamanetwork.com/journals/jama/fullarticle/2848242
This Research Letter reports the prespecified 6-month follow-up outcomes of the TIGHT K randomized clinical trial of potassium supplementation thresholds after cardiac surgery.
https://jamanetwork.com/journals/jama/fullarticle/2848242
This Research Letter reports the prespecified 6-month follow-up outcomes of the TIGHT K randomized clinical trial of potassium supplementation thresholds after cardiac surgery.
Lay Health Worker–Led Symptom Intervention for Older Adults With Cancer
https://jamanetwork.com/journals/jama/fullarticle/2848241
To the Editor Dr Patel and colleagues reported impressive results regarding a lay health worker–led symptom intervention that reduced emergency department use and hospitalizations among older adults with cancer. While the reported reduction in hospitalizations is remarkably higher than many previous electronic patient-reported outcome trials, the mechanism driving this magnitude of effect warrants further scrutiny before broad implementation.
https://jamanetwork.com/journals/jama/fullarticle/2848241
To the Editor Dr Patel and colleagues reported impressive results regarding a lay health worker–led symptom intervention that reduced emergency department use and hospitalizations among older adults with cancer. While the reported reduction in hospitalizations is remarkably higher than many previous electronic patient-reported outcome trials, the mechanism driving this magnitude of effect warrants further scrutiny before broad implementation.
Lay Health Worker–Led Symptom Intervention for Older Adults With Cancer—Reply
https://jamanetwork.com/journals/jama/fullarticle/2848240
In Reply I thank Dr Tang and colleagues for the questions they raise. The study reported the effect of proactive symptom assessment led by lay health workers on reductions in emergency department and hospitalization use among older adults with cancer. While proactive, frequent assessment and algorithm-driven access to timely interventions are underlying mechanisms of action, patient engagement is a foundational determinant. The success of any proactive cancer symptom assessment intervention relies heavily on patient engagement—patients must actively report their symptoms and symptom burden over time. Current modalities, such as electronic-based approaches alone, are fraught with high attrition, especially over time, thereby diminishing the reach and effectiveness. Furthermore, the engagement of older adults in these approaches is difficult to ascertain, given that few older adults were included in the studies that established effectiveness of electronic-based approaches.
https://jamanetwork.com/journals/jama/fullarticle/2848240
In Reply I thank Dr Tang and colleagues for the questions they raise. The study reported the effect of proactive symptom assessment led by lay health workers on reductions in emergency department and hospitalization use among older adults with cancer. While proactive, frequent assessment and algorithm-driven access to timely interventions are underlying mechanisms of action, patient engagement is a foundational determinant. The success of any proactive cancer symptom assessment intervention relies heavily on patient engagement—patients must actively report their symptoms and symptom burden over time. Current modalities, such as electronic-based approaches alone, are fraught with high attrition, especially over time, thereby diminishing the reach and effectiveness. Furthermore, the engagement of older adults in these approaches is difficult to ascertain, given that few older adults were included in the studies that established effectiveness of electronic-based approaches.
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Accelerating Workforce Well-Being—Lessons From Safety
https://jamanetwork.com/journals/jama/fullarticle/2848239
This Perspective discusses accelerating the implementation of known methods for protecting the health care workforce from burnout.
https://jamanetwork.com/journals/jama/fullarticle/2848239
This Perspective discusses accelerating the implementation of known methods for protecting the health care workforce from burnout.
Incorrect eTable 9 in Supplement 1
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2848040
The Original Investigation titled “SGLT2 Inhibitors and Risk for Hyperkalemia Among Individuals Receiving RAAS Inhibitors,” published online on April 28, 2025, and in the July 2025 print issue, was corrected to fix an error in the supplemental content. In Supplement 1, eTable 9 was originally published as a duplicate of eTable 10 and has been replaced with the correct table. This article has been corrected online.
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2848040
The Original Investigation titled “SGLT2 Inhibitors and Risk for Hyperkalemia Among Individuals Receiving RAAS Inhibitors,” published online on April 28, 2025, and in the July 2025 print issue, was corrected to fix an error in the supplemental content. In Supplement 1, eTable 9 was originally published as a duplicate of eTable 10 and has been replaced with the correct table. This article has been corrected online.
Mailed Colorectal Cancer Screening Outreach—In-House or Outsourced?
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2848039
Colorectal cancer (CRC) disproportionately affects underserved communities, and lower screening rates contribute to these disparities. Stool-based screening tests, including fecal immunochemical test (FIT) and FIT-DNA, are convenient options that can facilitate screening uptake in underserved populations. Stool-based tests have increased CRC screening rates and decreased racial disparities in CRC incidence and mortality, yet significant gaps remain.
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2848039
Colorectal cancer (CRC) disproportionately affects underserved communities, and lower screening rates contribute to these disparities. Stool-based screening tests, including fecal immunochemical test (FIT) and FIT-DNA, are convenient options that can facilitate screening uptake in underserved populations. Stool-based tests have increased CRC screening rates and decreased racial disparities in CRC incidence and mortality, yet significant gaps remain.
Lung Cancer Screening Turns 10
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2848038
In JAMA Internal Medicine, Burus and colleagues provide a snapshot of lung cancer screening (LCS) uptake with low-dose computed tomography 10 years after the US Preventive Services Task Force (USPSTF) first recommended this approach. The authors found that 24.5% of eligible individuals reported being up to date with the recommended LCS approach (ie, low-dose CT) in 2024. This represents steady progress compared to 2019 (12.8%) and 2022 (18.1%). Yet LCS rates still lag far behind those for other recommended cancer screenings: 67.4% for colorectal, 75.4% for cervical, and 80.0% for breast cancer.
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2848038
In JAMA Internal Medicine, Burus and colleagues provide a snapshot of lung cancer screening (LCS) uptake with low-dose computed tomography 10 years after the US Preventive Services Task Force (USPSTF) first recommended this approach. The authors found that 24.5% of eligible individuals reported being up to date with the recommended LCS approach (ie, low-dose CT) in 2024. This represents steady progress compared to 2019 (12.8%) and 2022 (18.1%). Yet LCS rates still lag far behind those for other recommended cancer screenings: 67.4% for colorectal, 75.4% for cervical, and 80.0% for breast cancer.