Missed Posterior Myocardial Infarction Leading to Free Wall Rupture
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2844098
This case report describes a patient in her early 60s who presented with substernal chest pain and diaphoresis.
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2844098
This case report describes a patient in her early 60s who presented with substernal chest pain and diaphoresis.
Targeted Remediation of the Ipsilesional Arm in Chronic Stroke
https://jamanetwork.com/journals/jamaneurology/fullarticle/2844558
This parallel-group randomized clinical trial determines whether training of the ipsilesional arm improves motor performance in chronic stroke with severe contralesional impairment and significant ipsilesional arm motor deficits.
https://jamanetwork.com/journals/jamaneurology/fullarticle/2844558
This parallel-group randomized clinical trial determines whether training of the ipsilesional arm improves motor performance in chronic stroke with severe contralesional impairment and significant ipsilesional arm motor deficits.
Plasma p-tau217 Cutoffs, Kidney Function, BMI, and Anemia
https://jamanetwork.com/journals/jamaneurology/fullarticle/2844557
This cohort study compares the performance of 3 plasma p-tau217 classification strategies for detecting amyloid-β positivity to consider which offers better optimize diagnostic accuracy and cost efficiency.
https://jamanetwork.com/journals/jamaneurology/fullarticle/2844557
This cohort study compares the performance of 3 plasma p-tau217 classification strategies for detecting amyloid-β positivity to consider which offers better optimize diagnostic accuracy and cost efficiency.
Serum Klotho Levels, Brain Structure, and Cognitive Performance
https://jamanetwork.com/journals/jamaneurology/fullarticle/2844556
This cross-sectional study investigates if circulating serum klotho levels modify the negative association between age-related brain atrophy and cognitive decline in a cognitively unimpaired, older adult cohort enriched for Alzheimer disease risk.
https://jamanetwork.com/journals/jamaneurology/fullarticle/2844556
This cross-sectional study investigates if circulating serum klotho levels modify the negative association between age-related brain atrophy and cognitive decline in a cognitively unimpaired, older adult cohort enriched for Alzheimer disease risk.
The Next Era of Idiopathic Normal Pressure Hydrocephalus
https://jamanetwork.com/journals/jamaneurology/fullarticle/2844555
This Viewpoint describes the diagnosis and treatment history of normal pressure hydrocephalus and then highlights recent trial results that may serve as a catalyst for renewed scientific and clinical efforts.
https://jamanetwork.com/journals/jamaneurology/fullarticle/2844555
This Viewpoint describes the diagnosis and treatment history of normal pressure hydrocephalus and then highlights recent trial results that may serve as a catalyst for renewed scientific and clinical efforts.
JAMA Cardiology—From Scientific Discovery to Population-Wide Delivery
https://jamanetwork.com/journals/jamacardiology/fullarticle/2844708
Dear JAMA Cardiology contributors and readers,
https://jamanetwork.com/journals/jamacardiology/fullarticle/2844708
Dear JAMA Cardiology contributors and readers,
JAMA Cardiology
https://jamanetwork.com/journals/jamacardiology/fullarticle/2844673
Mission Statement: JAMA Cardiology is positioned at the nexus of clinical investigation, actionable clinical science, and clinical practice, with emphasis on traditional cardiovascular medicine, evolving cardiovascular science, and evidence-based health policy. Health equity, especially when supported by original science, is a leading editorial priority.
https://jamanetwork.com/journals/jamacardiology/fullarticle/2844673
Mission Statement: JAMA Cardiology is positioned at the nexus of clinical investigation, actionable clinical science, and clinical practice, with emphasis on traditional cardiovascular medicine, evolving cardiovascular science, and evidence-based health policy. Health equity, especially when supported by original science, is a leading editorial priority.
Blood Pressure Above Goal Among US Adults With Hypertension
https://jamanetwork.com/journals/jama/fullarticle/2844633
This study used National Health and Nutrition Examination Survey 2021 to 2023 data to describe the proportion of US adults with uncontrolled blood pressure.
https://jamanetwork.com/journals/jama/fullarticle/2844633
This study used National Health and Nutrition Examination Survey 2021 to 2023 data to describe the proportion of US adults with uncontrolled blood pressure.
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Management of Premenstrual Disorders
https://jamanetwork.com/journals/jama/fullarticle/2844698
This JAMA Clinical Guidelines Synopsis summarizes the American College of Obstetricians and Gynecologists’ 2023 recommendations for management of premenstrual disorders.
https://jamanetwork.com/journals/jama/fullarticle/2844698
This JAMA Clinical Guidelines Synopsis summarizes the American College of Obstetricians and Gynecologists’ 2023 recommendations for management of premenstrual disorders.
Trends and Disparities in Heat-Related Emergency Medical Services Activations
https://jamanetwork.com/journals/jama/fullarticle/2844697
This study compares US sociodemographic and geographic trends in heat-related and non–heat-related emergency medical services (EMS) activations from 2019 to 2024.
https://jamanetwork.com/journals/jama/fullarticle/2844697
This study compares US sociodemographic and geographic trends in heat-related and non–heat-related emergency medical services (EMS) activations from 2019 to 2024.
Abelacimab vs Rivaroxaban in Older Individuals With AF
https://jamanetwork.com/journals/jamacardiology/fullarticle/2844582
This randomized clinical trial examines data via prespecified analysis to evaluate the bleeding risk of the novel factor XI inhibitor abelacimab vs rivaroxaban in patients with atrial fibrillation (AF) according to their age (<75 vs ≥75 years).
https://jamanetwork.com/journals/jamacardiology/fullarticle/2844582
This randomized clinical trial examines data via prespecified analysis to evaluate the bleeding risk of the novel factor XI inhibitor abelacimab vs rivaroxaban in patients with atrial fibrillation (AF) according to their age (<75 vs ≥75 years).
The Cost-Effectiveness Evolution of Cardiovascular Care
https://jamanetwork.com/journals/jamacardiology/fullarticle/2844581
Proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) and the glucagon-like peptide-1 receptor agonist (GLP-1RA) semaglutide represent 2 landmark innovations in cardiometabolic care. These agents, tested in rigorous randomized clinical trials, offer proven and substantial clinical benefit, PCSK9i through potent low-density lipoprotein cholesterol (LDL-C) reduction and reductions in atherosclerotic cardiovascular disease (ASCVD) events, and semaglutide through weight loss, reductions in kidney events, reductions in cardiovascular risk in patients with diabetes, ASCVD, and overweight/obesity, and heart failure with preserved ejection fraction. Yet, despite compelling clinical trial evidence for efficacy and safety, each therapy’s initial market entry and uptake was stifled, not by lack of need or effectiveness, but by a common barrier: cost. High pricing rendered both therapies cost-ineffective by conventional standards and of low value limiting access and utilization.
https://jamanetwork.com/journals/jamacardiology/fullarticle/2844581
Proprotein convertase subtilisin/kexin type 9 inhibitors (PCSK9i) and the glucagon-like peptide-1 receptor agonist (GLP-1RA) semaglutide represent 2 landmark innovations in cardiometabolic care. These agents, tested in rigorous randomized clinical trials, offer proven and substantial clinical benefit, PCSK9i through potent low-density lipoprotein cholesterol (LDL-C) reduction and reductions in atherosclerotic cardiovascular disease (ASCVD) events, and semaglutide through weight loss, reductions in kidney events, reductions in cardiovascular risk in patients with diabetes, ASCVD, and overweight/obesity, and heart failure with preserved ejection fraction. Yet, despite compelling clinical trial evidence for efficacy and safety, each therapy’s initial market entry and uptake was stifled, not by lack of need or effectiveness, but by a common barrier: cost. High pricing rendered both therapies cost-ineffective by conventional standards and of low value limiting access and utilization.
Cost-Effectiveness of Semaglutide for Secondary Prevention of Cardiovascular Disease in US Adults
https://jamanetwork.com/journals/jamacardiology/fullarticle/2844580
This study evaluates the cost-effectiveness of semaglutide for secondary prevention of cardiovascular disease and potential effect on US health care spending.
https://jamanetwork.com/journals/jamacardiology/fullarticle/2844580
This study evaluates the cost-effectiveness of semaglutide for secondary prevention of cardiovascular disease and potential effect on US health care spending.
Heart Sounds
https://jamanetwork.com/journals/jamacardiology/fullarticle/2844579
This poem describes parallels between waveforms seen on electrocardiograms and sonograms and patterns seen in nature.
https://jamanetwork.com/journals/jamacardiology/fullarticle/2844579
This poem describes parallels between waveforms seen on electrocardiograms and sonograms and patterns seen in nature.
Instruments of Precision, and Progress in Science
https://jamanetwork.com/journals/jama/fullarticle/2844760
Professor Zeleny, of the University of Minnesota, called attention recently to the indispensable service rendered to the progress of science by the development of instruments of precision. “Long experience,” he said, “has taught that however much we may owe to the great minds that evolve basic generalizations and hypotheses, real progress in science ultimately rests on the establishment of facts. Our reasoning faculties by themselves are unable to cope with the complexity in the physical world, and are sure to stray from reality unless they are continually guided by observation and experiment.” This is true not only for the physical sciences but also for the biologic sciences. As Professor Cope, one of the greatest of American zoologists, used to say, “Nature always proves to be less complex and ever so much more simple in her operations than would seem to be true to the theoretic considerations of the closet philosopher.” Facts always prove simpler than theories, and observations than hypotheses, and both owe their accuracy to instrumental precision more than anything else.
https://jamanetwork.com/journals/jama/fullarticle/2844760
Professor Zeleny, of the University of Minnesota, called attention recently to the indispensable service rendered to the progress of science by the development of instruments of precision. “Long experience,” he said, “has taught that however much we may owe to the great minds that evolve basic generalizations and hypotheses, real progress in science ultimately rests on the establishment of facts. Our reasoning faculties by themselves are unable to cope with the complexity in the physical world, and are sure to stray from reality unless they are continually guided by observation and experiment.” This is true not only for the physical sciences but also for the biologic sciences. As Professor Cope, one of the greatest of American zoologists, used to say, “Nature always proves to be less complex and ever so much more simple in her operations than would seem to be true to the theoretic considerations of the closet philosopher.” Facts always prove simpler than theories, and observations than hypotheses, and both owe their accuracy to instrumental precision more than anything else.
Audio Highlights February 6, 2026
https://jamanetwork.com/journals/jama/fullarticle/2844969
Listen to the JAMA Editor’s Summary for an overview and discussion of the important articles appearing in JAMA.
https://jamanetwork.com/journals/jama/fullarticle/2844969
Listen to the JAMA Editor’s Summary for an overview and discussion of the important articles appearing in JAMA.
Menopausal Hormone Labels Should Rely on Evidence, Not Opinion
https://jamanetwork.com/journals/jama/fullarticle/2844960
This Viewpoint discusses weighing the evidence of benefits and risks of various estrogen products following the US Food and Drug Administration’s decision to remove most box warnings from hormone replacement therapy products.
https://jamanetwork.com/journals/jama/fullarticle/2844960
This Viewpoint discusses weighing the evidence of benefits and risks of various estrogen products following the US Food and Drug Administration’s decision to remove most box warnings from hormone replacement therapy products.
Alcohol-Related Emergency Department Visits Increase
https://jamanetwork.com/journals/jama/fullarticle/2844968
Alcohol-related emergency department visits approximately doubled from 2003-2004 to 2021-2022, according to the US Centers for Disease Control and Prevention.
https://jamanetwork.com/journals/jama/fullarticle/2844968
Alcohol-related emergency department visits approximately doubled from 2003-2004 to 2021-2022, according to the US Centers for Disease Control and Prevention.
Home Blood Pressure Monitoring Remains Low Despite Assistance
https://jamanetwork.com/journals/jama/fullarticle/2844967
Despite free monitors and ongoing support, patient engagement with home blood pressure monitoring was suboptimal in a recent study.
https://jamanetwork.com/journals/jama/fullarticle/2844967
Despite free monitors and ongoing support, patient engagement with home blood pressure monitoring was suboptimal in a recent study.
Vaccinations Dip Among Older Adults
https://jamanetwork.com/journals/jama/fullarticle/2844966
Fewer older adults were vaccinated against influenza and pneumonia in 2024 than in 2019, the US Centers for Disease Control and Prevention’s National Center for Health Statistics reported in a data brief.
https://jamanetwork.com/journals/jama/fullarticle/2844966
Fewer older adults were vaccinated against influenza and pneumonia in 2024 than in 2019, the US Centers for Disease Control and Prevention’s National Center for Health Statistics reported in a data brief.