Pharmaceutical Pricing—JAMA Talks With Mark Cuban
https://jamanetwork.com/journals/jama/fullarticle/2845124
JAMA and JAMA Network Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, spoke with Mark Cuban, entrepreneur and cofounder of the Mark Cuban Cost Plus Drugs Company, about pharmaceutical pricing.
https://jamanetwork.com/journals/jama/fullarticle/2845124
JAMA and JAMA Network Editor in Chief Kirsten Bibbins-Domingo, PhD, MD, MAS, spoke with Mark Cuban, entrepreneur and cofounder of the Mark Cuban Cost Plus Drugs Company, about pharmaceutical pricing.
Outcomes of Same-Sex Female Couples Pursuing Autologous and Reciprocal IVF
https://jamanetwork.com/journals/jama/fullarticle/2845067
This study compares embryo transfer and pregnancy outcomes among US same-sex female couples undergoing reciprocal and autologous oocyte in vitro fertilization (IVF) cycles.
https://jamanetwork.com/journals/jama/fullarticle/2845067
This study compares embryo transfer and pregnancy outcomes among US same-sex female couples undergoing reciprocal and autologous oocyte in vitro fertilization (IVF) cycles.
Syphilis and Cerebrospinal Fluid Examination
https://jamanetwork.com/journals/jama/fullarticle/2845066
To the Editor The recent Review by Dr Chevalier and colleagues on syphilis provides a comprehensive overview of this reemerging infection. The section on neurosyphilis is particularly valuable for clinicians confronted with diagnostic uncertainty in patients with neurologic or psychiatric symptoms.
https://jamanetwork.com/journals/jama/fullarticle/2845066
To the Editor The recent Review by Dr Chevalier and colleagues on syphilis provides a comprehensive overview of this reemerging infection. The section on neurosyphilis is particularly valuable for clinicians confronted with diagnostic uncertainty in patients with neurologic or psychiatric symptoms.
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Audio Highlights February 13, 2026
https://jamanetwork.com/journals/jama/fullarticle/2845262
Listen to the JAMA Editor’s Summary for an overview and discussion of the important articles appearing in JAMA.
https://jamanetwork.com/journals/jama/fullarticle/2845262
Listen to the JAMA Editor’s Summary for an overview and discussion of the important articles appearing in JAMA.
How ICE Crackdowns Are Disrupting Health Care
https://jamanetwork.com/journals/jama/fullarticle/2845182
This Medical News article discusses how the ongoing crackdown by US Immigration and Customs Enforcement is preventing some patients from obtaining health care.
https://jamanetwork.com/journals/jama/fullarticle/2845182
This Medical News article discusses how the ongoing crackdown by US Immigration and Customs Enforcement is preventing some patients from obtaining health care.
US Life Expectancy Rebounds to Prepandemic High
https://jamanetwork.com/journals/jama/fullarticle/2845189
Life expectancy in the US rose back to 79 years in 2024, up from 78 years in 2023.
https://jamanetwork.com/journals/jama/fullarticle/2845189
Life expectancy in the US rose back to 79 years in 2024, up from 78 years in 2023.
Measles Outbreak Worsens in South Carolina
https://jamanetwork.com/journals/jama/fullarticle/2845188
Measles cases in South Carolina reached 920 as of February 6, according to an update from the state’s public health department.
https://jamanetwork.com/journals/jama/fullarticle/2845188
Measles cases in South Carolina reached 920 as of February 6, according to an update from the state’s public health department.
Association Between GLP-1 RAs and Idiopathic Intracranial Hypertension
https://jamanetwork.com/journals/jamaneurology/fullarticle/2845195
To the Editor We read with great interest the recent article by Sioutas et al examining the association between glucagon-like peptide 1 receptor agonists (GLP-1 RAs) and idiopathic intracranial hypertension (IIH). This nationwide cohort analysis provides valuable epidemiologic insight into a field where mechanistic and clinical questions remain open. However, we believe that some aspects require clarification and further stratification in order to strengthen the proposed association.
https://jamanetwork.com/journals/jamaneurology/fullarticle/2845195
To the Editor We read with great interest the recent article by Sioutas et al examining the association between glucagon-like peptide 1 receptor agonists (GLP-1 RAs) and idiopathic intracranial hypertension (IIH). This nationwide cohort analysis provides valuable epidemiologic insight into a field where mechanistic and clinical questions remain open. However, we believe that some aspects require clarification and further stratification in order to strengthen the proposed association.
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Statins for Primary Prevention
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2844663
When should we consider using statins for primary prevention of atherosclerotic cardiovascular disease (ASCVD)? Statins consistently reduce the relative risk of ASCVD by about 25%, across baseline levels of risk. Accordingly, clinical practice guidelines recommend offering statins for primary prevention when 10-year ASCVD risk estimates are anticipated to outweigh absolute risks of serious adverse events. The current American College of Cardiology and American Heart Association guideline recommends statins for patients with a 10-year ASCVD risk of 7.5% or higher, although with the advent of more accurate risk calculators, lower treatment thresholds of 3% or 5% have recently been proposed. Among patients at a lower cardiovascular risk, statins may still be considered, but their benefit in terms of absolute reduction in risk of cardiovascular events is smaller and may no longer outweigh adverse event risks.
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2844663
When should we consider using statins for primary prevention of atherosclerotic cardiovascular disease (ASCVD)? Statins consistently reduce the relative risk of ASCVD by about 25%, across baseline levels of risk. Accordingly, clinical practice guidelines recommend offering statins for primary prevention when 10-year ASCVD risk estimates are anticipated to outweigh absolute risks of serious adverse events. The current American College of Cardiology and American Heart Association guideline recommends statins for patients with a 10-year ASCVD risk of 7.5% or higher, although with the advent of more accurate risk calculators, lower treatment thresholds of 3% or 5% have recently been proposed. Among patients at a lower cardiovascular risk, statins may still be considered, but their benefit in terms of absolute reduction in risk of cardiovascular events is smaller and may no longer outweigh adverse event risks.
Addressing Food Insecurity Is Complicated but Needed
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2844662
A healthy diet, alongside exercise, plays a vital role in preventing and helping manage many chronic conditions, including diabetes, hypertension, and obesity. There are different barriers to being able to maintain a healthy diet, and one such intervenable barrier is food insecurity, which is when households do not have consistent, dependable access to enough food for active, healthy living.
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2844662
A healthy diet, alongside exercise, plays a vital role in preventing and helping manage many chronic conditions, including diabetes, hypertension, and obesity. There are different barriers to being able to maintain a healthy diet, and one such intervenable barrier is food insecurity, which is when households do not have consistent, dependable access to enough food for active, healthy living.
Personalized Hemodynamic Resuscitation in Early Septic Shock
https://jamanetwork.com/journals/jama/fullarticle/2845232
To the Editor The ANDROMEDA-SHOCK-2 randomized clinical trial reported that patients randomized to a multicomponent septic shock resuscitation strategy experienced benefit compared with those who were randomized to usual care, based on a win ratio analysis of mortality, duration of vital support, and length of stay. There was no evidence that the benefit of the intervention differed based on subgroups stratified by participant age, multiple measures of severity of illness, and septic shock source. However, a post hoc analysis of treatment effect by study site (eFigure 5) suggested that the effectiveness of the intervention ranged from benefit at some study sites to harm at other study sites.
https://jamanetwork.com/journals/jama/fullarticle/2845232
To the Editor The ANDROMEDA-SHOCK-2 randomized clinical trial reported that patients randomized to a multicomponent septic shock resuscitation strategy experienced benefit compared with those who were randomized to usual care, based on a win ratio analysis of mortality, duration of vital support, and length of stay. There was no evidence that the benefit of the intervention differed based on subgroups stratified by participant age, multiple measures of severity of illness, and septic shock source. However, a post hoc analysis of treatment effect by study site (eFigure 5) suggested that the effectiveness of the intervention ranged from benefit at some study sites to harm at other study sites.
Coronary Plaque Progression After Androgen Deprivation Therapy in Men With Prostate Cancer
https://jamanetwork.com/journals/jamacardiology/fullarticle/2845162
This randomized clinical trial tests the hypothesis that androgen deprivation therapy is associated with accelerated coronary atherosclerosis and is more prominent with a gonadotropin-releasing hormone agonist vs an antagonist.
https://jamanetwork.com/journals/jamacardiology/fullarticle/2845162
This randomized clinical trial tests the hypothesis that androgen deprivation therapy is associated with accelerated coronary atherosclerosis and is more prominent with a gonadotropin-releasing hormone agonist vs an antagonist.
Assessment for Long-Term Cardiovascular Disease Risk in Pregnancy
https://jamanetwork.com/journals/jamacardiology/fullarticle/2845161
Pregnancy is well recognized as a critical period in a woman’s life course when physiologic changes intended to support the growing fetus can have adverse sequelae for long-term cardiovascular health. Adverse pregnancy outcomes are rising in prevalence, complicate nearly 1 in 5 pregnancies in the US, and include hypertensive disorders of pregnancy, gestational diabetes, preterm birth, and having a small-for-gestational-age infant. Ample observational data demonstrate that these adverse pregnancy outcomes are associated with increased maternal risk of cardiovascular disease (CVD) in the short and long term. As a result, pregnancy is commonly referred to as a stress test, which provides a window to future cardiovascular health for women. This knowledge has led to growing calls by national and international professional societies to recognize pregnancy and the postpartum period as opportunistic moments for CVD risk assessment and cardiovascular health counseling. This recognition of the importance of pregnancy in a person’s overall health has also coincided with growing interest in the potential utility of circulating biomarkers to improve risk assessment in nonpregnant populations. However, critical gaps remain regarding the potential utility of biomarkers assessed during pregnancy.
https://jamanetwork.com/journals/jamacardiology/fullarticle/2845161
Pregnancy is well recognized as a critical period in a woman’s life course when physiologic changes intended to support the growing fetus can have adverse sequelae for long-term cardiovascular health. Adverse pregnancy outcomes are rising in prevalence, complicate nearly 1 in 5 pregnancies in the US, and include hypertensive disorders of pregnancy, gestational diabetes, preterm birth, and having a small-for-gestational-age infant. Ample observational data demonstrate that these adverse pregnancy outcomes are associated with increased maternal risk of cardiovascular disease (CVD) in the short and long term. As a result, pregnancy is commonly referred to as a stress test, which provides a window to future cardiovascular health for women. This knowledge has led to growing calls by national and international professional societies to recognize pregnancy and the postpartum period as opportunistic moments for CVD risk assessment and cardiovascular health counseling. This recognition of the importance of pregnancy in a person’s overall health has also coincided with growing interest in the potential utility of circulating biomarkers to improve risk assessment in nonpregnant populations. However, critical gaps remain regarding the potential utility of biomarkers assessed during pregnancy.
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Clinical Factors and Biomarkers During Pregnancy and Risk of Cardiovascular Disease
https://jamanetwork.com/journals/jamacardiology/fullarticle/2845160
This cohort study evaluates the association between clinical biomarkers obtained during pregnancy and long-term risk of cardiovascular disease.
https://jamanetwork.com/journals/jamacardiology/fullarticle/2845160
This cohort study evaluates the association between clinical biomarkers obtained during pregnancy and long-term risk of cardiovascular disease.
Disruptions in Medicare Advantage Coverage in 2026
https://jamanetwork.com/journals/jama/fullarticle/2845239
Imagine learning during open enrollment that your Medicare Advantage plan is exiting the market, forcing you to find new coverage for 2026. In Vermont, a staggering 92% of Medicare Advantage enrollees face exactly this situation. Nationally, 2.9 million beneficiaries, roughly 1 in 10 Medicare Advantage enrollees, have been forced to change their insurance coverage due to their prior plan exiting the market (forced disenrollment). The research letter by Meiselbach and colleagues documents this unprecedented disruption. Between 2018 and 2024, mean forced disenrollment was just 1% annually. After years of stable market participation, forced disenrollment rates surged to 6.9% in 2025 and are expected to reach approximately 10% in 2026.
https://jamanetwork.com/journals/jama/fullarticle/2845239
Imagine learning during open enrollment that your Medicare Advantage plan is exiting the market, forcing you to find new coverage for 2026. In Vermont, a staggering 92% of Medicare Advantage enrollees face exactly this situation. Nationally, 2.9 million beneficiaries, roughly 1 in 10 Medicare Advantage enrollees, have been forced to change their insurance coverage due to their prior plan exiting the market (forced disenrollment). The research letter by Meiselbach and colleagues documents this unprecedented disruption. Between 2018 and 2024, mean forced disenrollment was just 1% annually. After years of stable market participation, forced disenrollment rates surged to 6.9% in 2025 and are expected to reach approximately 10% in 2026.
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Pertussis Infection in Adults
https://jamanetwork.com/journals/jama/fullarticle/2845238
This JAMA Insights discusses the epidemiology, transmission, and risk factors for pertussis, also referred to as whooping cough, in adults.
https://jamanetwork.com/journals/jama/fullarticle/2845238
This JAMA Insights discusses the epidemiology, transmission, and risk factors for pertussis, also referred to as whooping cough, in adults.
Stereotactic Radiosurgery in Brain Metastasis Treatment
https://jamanetwork.com/journals/jama/fullarticle/2845317
In this issue of JAMA, Aizer and colleagues present the results of a randomized clinical trial demonstrating that patients with 5 to 20 brain metastases receiving stereotactic radiosurgery experience a lower symptom severity and less interference with daily functioning than patients who receive hippocampal-avoidance whole brain radiation. This study should be viewed from the perspective of where it fits with respect to studies published over the past 2 decades, as well as from the perspective of the evolving brain metastasis population, which has experienced a significant stage migration over the same period.
https://jamanetwork.com/journals/jama/fullarticle/2845317
In this issue of JAMA, Aizer and colleagues present the results of a randomized clinical trial demonstrating that patients with 5 to 20 brain metastases receiving stereotactic radiosurgery experience a lower symptom severity and less interference with daily functioning than patients who receive hippocampal-avoidance whole brain radiation. This study should be viewed from the perspective of where it fits with respect to studies published over the past 2 decades, as well as from the perspective of the evolving brain metastasis population, which has experienced a significant stage migration over the same period.
Sunshine and Skyshine
https://jamanetwork.com/journals/jama/fullarticle/2845316
The importance of sunshine for the welfare of plants has long been recognized. It has also been suspected, to express it mildly, that the vegetative functions of animal kind in general and man in particular derive some sort of benefit from the same agency. Fresh air and sunshine have formed the basis of innumerable prescriptions to those who seek to regain good health or to retain it. Only recently, however, has the significance of the invisible radiations begun to be appreciated. As Hess has pointed out, the ultraviolet rays constitute less than 1 per cent of the total solar radiations, and it is therefore all the more remarkable that they should prove to be essential to the well being of man. The young, rapidly growing infant thrives better when deprived of the visible rays than when deprived of the ultraviolet rays of the sun. The law of the vital importance of the minimum applies to the radiations of the sun; those rays which are furnished in smallest amount and in least intensity are nevertheless indispensable.
https://jamanetwork.com/journals/jama/fullarticle/2845316
The importance of sunshine for the welfare of plants has long been recognized. It has also been suspected, to express it mildly, that the vegetative functions of animal kind in general and man in particular derive some sort of benefit from the same agency. Fresh air and sunshine have formed the basis of innumerable prescriptions to those who seek to regain good health or to retain it. Only recently, however, has the significance of the invisible radiations begun to be appreciated. As Hess has pointed out, the ultraviolet rays constitute less than 1 per cent of the total solar radiations, and it is therefore all the more remarkable that they should prove to be essential to the well being of man. The young, rapidly growing infant thrives better when deprived of the visible rays than when deprived of the ultraviolet rays of the sun. The law of the vital importance of the minimum applies to the radiations of the sun; those rays which are furnished in smallest amount and in least intensity are nevertheless indispensable.
Billing of Medicare’s G2211 Longitudinal Care Code Among Traditional Medicare Beneficiaries
https://jamanetwork.com/journals/jama/fullarticle/2845315
This study examines patterns of Medicare’s G2211 billing code to understand its uptake and how often these payments went to primary care.
https://jamanetwork.com/journals/jama/fullarticle/2845315
This study examines patterns of Medicare’s G2211 billing code to understand its uptake and how often these payments went to primary care.
Bioresorbable vs Metallic Occluder for Transcatheter Atrial Septal Defect Closure
https://jamanetwork.com/journals/jama/fullarticle/2845314
To the Editor A recent article comparing bioresorbable vs metallic occluders for transcatheter atrial septal defect closure demonstrated excellent bioresorption at 2 years and noninferior efficacy of the bioresorbable device. I wish to highlight several aspects that help contextualize the implications of this study.
https://jamanetwork.com/journals/jama/fullarticle/2845314
To the Editor A recent article comparing bioresorbable vs metallic occluders for transcatheter atrial septal defect closure demonstrated excellent bioresorption at 2 years and noninferior efficacy of the bioresorbable device. I wish to highlight several aspects that help contextualize the implications of this study.
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