Clarifying the SOFA-2 Score
https://jamanetwork.com/journals/jama/fullarticle/2846535
To the Editor Dr Ranzani and colleagues describe the development and validation of the SOFA-2 score, a major update of an organ dysfunction index central to both clinical research and bedside assessment in critical care medicine.
https://jamanetwork.com/journals/jama/fullarticle/2846535
To the Editor Dr Ranzani and colleagues describe the development and validation of the SOFA-2 score, a major update of an organ dysfunction index central to both clinical research and bedside assessment in critical care medicine.
Clarifying the SOFA-2 Score
https://jamanetwork.com/journals/jama/fullarticle/2846534
To the Editor As members of the Executive Committee of the European Group on Immunology of Sepsis (EGIS), we are writing about the recent article describing the development and validation of the SOFA-2 score. The authors revised the original SOFA score by integrating modern intensive care unit (ICU) interventions such as renal replacement therapy and extracorporeal membrane oxygenation, resulting in an updated index reflecting contemporary ICU practice.
https://jamanetwork.com/journals/jama/fullarticle/2846534
To the Editor As members of the Executive Committee of the European Group on Immunology of Sepsis (EGIS), we are writing about the recent article describing the development and validation of the SOFA-2 score. The authors revised the original SOFA score by integrating modern intensive care unit (ICU) interventions such as renal replacement therapy and extracorporeal membrane oxygenation, resulting in an updated index reflecting contemporary ICU practice.
Clarifying the SOFA-2 Score—Reply
https://jamanetwork.com/journals/jama/fullarticle/2846532
In Reply We appreciate the interest in the updated SOFA score (SOFA-2). We reiterate herein that SOFA-2 is primarily a descriptive scale to quantify organ dysfunction and is not a predictive score. The area under the receiver operating curve mentioned by Mr Matos and colleagues is reported as a metric to demonstrate predictive validity, 1 of 6 utility domains prespecified in our protocol.
https://jamanetwork.com/journals/jama/fullarticle/2846532
In Reply We appreciate the interest in the updated SOFA score (SOFA-2). We reiterate herein that SOFA-2 is primarily a descriptive scale to quantify organ dysfunction and is not a predictive score. The area under the receiver operating curve mentioned by Mr Matos and colleagues is reported as a metric to demonstrate predictive validity, 1 of 6 utility domains prespecified in our protocol.
Error in Text
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2846286
In the Invited Commentary titled “Reducing Early Stroke Recurrence Risk—Beyond Antithrombotics,” published online November 3, 2025, and in the January 2026 issue, there was an error in the text. In the second paragraph, the text was updated to “Neither statins nor early initiation of antihypertensive agents have shown early benefit for patients with acute ischemic stroke.” This article was corrected online.
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2846286
In the Invited Commentary titled “Reducing Early Stroke Recurrence Risk—Beyond Antithrombotics,” published online November 3, 2025, and in the January 2026 issue, there was an error in the text. In the second paragraph, the text was updated to “Neither statins nor early initiation of antihypertensive agents have shown early benefit for patients with acute ischemic stroke.” This article was corrected online.
JAMA Internal Medicine Peer Reviewers in 2025
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2846276
We sincerely thank the 1127 peer reviewers who completed manuscript reviews for JAMA Internal Medicine in 2025.
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2846276
We sincerely thank the 1127 peer reviewers who completed manuscript reviews for JAMA Internal Medicine in 2025.
eConsult-Integrated Care to Improve Specialty Access
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2846275
This Viewpoint discusses eConsult-integrated care to improve access to specialty health care.
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2846275
This Viewpoint discusses eConsult-integrated care to improve access to specialty health care.
Extended-Release Buprenorphine During Pregnancy and the First Year After Birth
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2846284
Pregnant and parenting people are among the groups most negatively impacted by the opioid crisis, yet they are last in line for rigorous medication research to improve outcomes. Overdose continues to be a leading cause of maternal deaths in the United States, and substance use is the primary reason infants are separated from their parents.
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2846284
Pregnant and parenting people are among the groups most negatively impacted by the opioid crisis, yet they are last in line for rigorous medication research to improve outcomes. Overdose continues to be a leading cause of maternal deaths in the United States, and substance use is the primary reason infants are separated from their parents.
Understanding the Health Impacts of the Rapid Shift to Opioid Smoking in the US
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2846283
The US is experiencing a historically unprecedented large-scale shift from opioid injecting to smoking. The US Centers for Disease Control and Prevention reports that more fatal drug overdoses now involve smoking than any other route of administration. Previously thought to be rare in the US, opioid smoking appears to be growing in nearly every US state. Its geographic spread, though, has been heterogeneous, initially increasing and reaching its highest prevalence in the Western US. Recent qualitative studies have explored the motivation for this trend. These studies report that many individuals who smoke opioids perceive that smoking instead of injecting reduces their risk of overdose, infections, and wounds, minimizes the frustration of repeated injection, and avoids injection-related stigma.
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2846283
The US is experiencing a historically unprecedented large-scale shift from opioid injecting to smoking. The US Centers for Disease Control and Prevention reports that more fatal drug overdoses now involve smoking than any other route of administration. Previously thought to be rare in the US, opioid smoking appears to be growing in nearly every US state. Its geographic spread, though, has been heterogeneous, initially increasing and reaching its highest prevalence in the Western US. Recent qualitative studies have explored the motivation for this trend. These studies report that many individuals who smoke opioids perceive that smoking instead of injecting reduces their risk of overdose, infections, and wounds, minimizes the frustration of repeated injection, and avoids injection-related stigma.
Monitoring After Treatment of Precancerous Cervical Lesions
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2846282
This Clinical Insights provides a comprehensive overview of monitoring patients after treatment of precancerous cervical lesions.
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2846282
This Clinical Insights provides a comprehensive overview of monitoring patients after treatment of precancerous cervical lesions.
Cognitive Behavioral Therapy for Insomnia in Chronic Disease
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2846280
To the Editor We read with great interest the recent meta-analysis by Scott et al evaluating the efficacy and acceptability of cognitive behavioral therapy for insomnia (CBT-I) in patients with chronic disease and comorbid insomnia. The findings reinforce treatment guidelines recommending CBT-I as the first-line treatment for adults with insomnia, including those with comorbid conditions. We are glad to see this important study published and believe that further in-depth discussion on clinical aspects could strengthen the study’s implications.
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2846280
To the Editor We read with great interest the recent meta-analysis by Scott et al evaluating the efficacy and acceptability of cognitive behavioral therapy for insomnia (CBT-I) in patients with chronic disease and comorbid insomnia. The findings reinforce treatment guidelines recommending CBT-I as the first-line treatment for adults with insomnia, including those with comorbid conditions. We are glad to see this important study published and believe that further in-depth discussion on clinical aspects could strengthen the study’s implications.
JAMA Neurology Year in Review, 2025
https://jamanetwork.com/journals/jamaneurology/fullarticle/2846475
As our editorial team starts our 10th year helping to shepherd this wonderful journal, we want to take a moment to thank all of the many authors, peer reviewers, editors, and staff who made 2025 so successful for JAMA Neurology.
https://jamanetwork.com/journals/jamaneurology/fullarticle/2846475
As our editorial team starts our 10th year helping to shepherd this wonderful journal, we want to take a moment to thank all of the many authors, peer reviewers, editors, and staff who made 2025 so successful for JAMA Neurology.
PrimeC in Amyotrophic Lateral Sclerosis
https://jamanetwork.com/journals/jamaneurology/fullarticle/2846474
This randomized clinical trial assesses the safety, tolerability, and potential efficacy of PrimeC in people living with ALS.
https://jamanetwork.com/journals/jamaneurology/fullarticle/2846474
This randomized clinical trial assesses the safety, tolerability, and potential efficacy of PrimeC in people living with ALS.
Humble by Experience
https://jamanetwork.com/journals/jamaneurology/fullarticle/2846473
This essay describes the author’s experience of being diagnosed and treated for an arteriovenous malformation during his residency and the new perspectives that being placed in the role of patient gave him.
https://jamanetwork.com/journals/jamaneurology/fullarticle/2846473
This essay describes the author’s experience of being diagnosed and treated for an arteriovenous malformation during his residency and the new perspectives that being placed in the role of patient gave him.
JAMA Neurology Peer Reviewers in 2025
https://jamanetwork.com/journals/jamaneurology/fullarticle/2846472
We sincerely thank the 872 peer reviewers who completed manuscript reviews for JAMA Neurology in 2025.
https://jamanetwork.com/journals/jamaneurology/fullarticle/2846472
We sincerely thank the 872 peer reviewers who completed manuscript reviews for JAMA Neurology in 2025.
Physical Restraint Use in Critical Care
https://jamanetwork.com/journals/jama/fullarticle/2846727
I was already fighting so much, not only for my life, but just like the need for a drop of water and any basic human need was being taken away anyway and then not to have the use of your bodily parts, your hands to hug somebody, to wipe away tears, to help you talk.Perez et al
https://jamanetwork.com/journals/jama/fullarticle/2846727
I was already fighting so much, not only for my life, but just like the need for a drop of water and any basic human need was being taken away anyway and then not to have the use of your bodily parts, your hands to hug somebody, to wipe away tears, to help you talk.Perez et al
Restrictive vs Liberal Physical Restraint Strategies in Critically Ill Patients
https://jamanetwork.com/journals/jama/fullarticle/2846726
This randomized clinical trial examines the effect of a low-use vs high-use physical restraint strategy in critically ill patients receiving invasive mechanical ventilation in the intensive care unit.
https://jamanetwork.com/journals/jama/fullarticle/2846726
This randomized clinical trial examines the effect of a low-use vs high-use physical restraint strategy in critically ill patients receiving invasive mechanical ventilation in the intensive care unit.
Restrictive vs Liberal Physical Restraint Strategies in Critically Ill Patients Research Summary
https://jamanetwork.com/journals/jama/fullarticle/2846725
This trial investigated whether a low-use, restrictive wrist-strap physical restraint strategy reduces coma or delirium in adult patients receiving mechanical ventilation in the intensive care unit (ICU) compared with a high-use, liberal strategy.
https://jamanetwork.com/journals/jama/fullarticle/2846725
This trial investigated whether a low-use, restrictive wrist-strap physical restraint strategy reduces coma or delirium in adult patients receiving mechanical ventilation in the intensive care unit (ICU) compared with a high-use, liberal strategy.
Treatment of Helicobacter pylori Infection
https://jamanetwork.com/journals/jama/fullarticle/2846629
This JAMA Clinical Guidelines Synopsis summarizes the American College of Gastroenterology’s 2024 guideline on treatment of Helicobacter pylori infection.
https://jamanetwork.com/journals/jama/fullarticle/2846629
This JAMA Clinical Guidelines Synopsis summarizes the American College of Gastroenterology’s 2024 guideline on treatment of Helicobacter pylori infection.
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Premature Menopause and Lifetime Risk of Coronary Heart Disease
https://jamanetwork.com/journals/jamacardiology/fullarticle/2846695
This cohort study calculates lifetime risk estimates of incident coronary heart disease and estimates years lived free of and with coronary heart disease by premature menopause status stratified by self-identified race.
https://jamanetwork.com/journals/jamacardiology/fullarticle/2846695
This cohort study calculates lifetime risk estimates of incident coronary heart disease and estimates years lived free of and with coronary heart disease by premature menopause status stratified by self-identified race.
JAMA Cardiology Year in Review, 2025
https://jamanetwork.com/journals/jamacardiology/fullarticle/2846694
Each year at this time, JAMA Cardiology publishes a brief review of the past year’s metrics and highlights. This review of 2025 is special, as it marks our 10th year of publishing and the passing of the baton from the inaugural editors to the new editorial team.
https://jamanetwork.com/journals/jamacardiology/fullarticle/2846694
Each year at this time, JAMA Cardiology publishes a brief review of the past year’s metrics and highlights. This review of 2025 is special, as it marks our 10th year of publishing and the passing of the baton from the inaugural editors to the new editorial team.