Bundled Payments—Looking Beyond the Episode
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2848037
Medicare spending costs taxpayers over $1.1 trillion, representing the second largest item in the federal budget. With rising health care spending, Congress created the Centers for Medicare and Medicaid Innovation (CMMI) in 2010 to test approaches to improve the value of health care by reducing spending and maintaining or improving quality. Accordingly, CMMI created several alternative payment models (APMs), including bundled payments, shared savings models, and capitated payments. The Oncology Care Model (OCM), which ran from 2016 to 2022, is one example of an APM created to test whether an episode-based bundled payment for systemic cancer therapy could improve the value of care for patients with cancer.
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2848037
Medicare spending costs taxpayers over $1.1 trillion, representing the second largest item in the federal budget. With rising health care spending, Congress created the Centers for Medicare and Medicaid Innovation (CMMI) in 2010 to test approaches to improve the value of health care by reducing spending and maintaining or improving quality. Accordingly, CMMI created several alternative payment models (APMs), including bundled payments, shared savings models, and capitated payments. The Oncology Care Model (OCM), which ran from 2016 to 2022, is one example of an APM created to test whether an episode-based bundled payment for systemic cancer therapy could improve the value of care for patients with cancer.
Temporal Patterns in Stroke Recurrence at Younger Ages
https://jamanetwork.com/journals/jamaneurology/fullarticle/2848082
This systematic review and meta-analysis analyzes temporal patterns in recurrence after ischemic stroke and transient ischemic attack to determine whether recurrence rates have changed over time among young stroke survivors.
https://jamanetwork.com/journals/jamaneurology/fullarticle/2848082
This systematic review and meta-analysis analyzes temporal patterns in recurrence after ischemic stroke and transient ischemic attack to determine whether recurrence rates have changed over time among young stroke survivors.
Risk of Cancer in Patients With First-Time Seizure
https://jamanetwork.com/journals/jamaneurology/fullarticle/2848080
This population-based cohort study examines neurological and nonneurological cancer risk in patients with first-time seizures vs the general Danish population.
https://jamanetwork.com/journals/jamaneurology/fullarticle/2848080
This population-based cohort study examines neurological and nonneurological cancer risk in patients with first-time seizures vs the general Danish population.
Acute Brain Injury in New-Onset Refractory Status Epilepticus
https://jamanetwork.com/journals/jamaneurology/fullarticle/2848081
This cross-sectional study investigates the brain damage occurring during the acute phase of new-onset refractory status epilepticus as indexed by serum and cerebrospinal fluid levels of neurofilament light chain and S100-beta proteins.
https://jamanetwork.com/journals/jamaneurology/fullarticle/2848081
This cross-sectional study investigates the brain damage occurring during the acute phase of new-onset refractory status epilepticus as indexed by serum and cerebrospinal fluid levels of neurofilament light chain and S100-beta proteins.
Efficacy and Safety of Vemircopan in Generalized Myasthenia Gravis
https://jamanetwork.com/journals/jamaneurology/fullarticle/2848079
This phase 2 randomized clinical trial evaluates the efficacy, safety, pharmacokinetics, and pharmacodynamics of vemircopan in adults with acetylcholine receptor antibody-positive generalized myasthenia gravis.
https://jamanetwork.com/journals/jamaneurology/fullarticle/2848079
This phase 2 randomized clinical trial evaluates the efficacy, safety, pharmacokinetics, and pharmacodynamics of vemircopan in adults with acetylcholine receptor antibody-positive generalized myasthenia gravis.
From the Heart: Eugene Braunwald (1929-2026)
https://jamanetwork.com/journals/jamacardiology/fullarticle/2848555
This article commemorates the life and achievements of Eugene Braunwald (1929-2026).
https://jamanetwork.com/journals/jamacardiology/fullarticle/2848555
This article commemorates the life and achievements of Eugene Braunwald (1929-2026).
Pigmentary Changes That Developed During Pregnancy
https://jamanetwork.com/journals/jama/fullarticle/2848382
A Black woman of Hispanic ethnicity with a history of hypertension, obesity, and headaches had symmetrically distributed, well-demarcated hyperpigmented lines that had developed during pregnancy and that extended from her buttocks to the lower extremities; physical examination was otherwise unremarkable. What is the diagnosis and what would you do next?
https://jamanetwork.com/journals/jama/fullarticle/2848382
A Black woman of Hispanic ethnicity with a history of hypertension, obesity, and headaches had symmetrically distributed, well-demarcated hyperpigmented lines that had developed during pregnancy and that extended from her buttocks to the lower extremities; physical examination was otherwise unremarkable. What is the diagnosis and what would you do next?
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Sibling Comparisons to Account for Confounding
https://jamanetwork.com/journals/jama/fullarticle/2848381
To the Editor Sibling comparison designs have reemerged as an important analytical approach for addressing unmeasured familial confounding in observational studies, particularly in perinatal and life-course epidemiology. The recent JAMA Guide to Statistics and Methods by Dr Ahlqvist and colleagues emphasized a renewed need for this study across pregnancy, environmental, psychiatric, and neurological research and discussed its potential utility in strengthening causal inference.
https://jamanetwork.com/journals/jama/fullarticle/2848381
To the Editor Sibling comparison designs have reemerged as an important analytical approach for addressing unmeasured familial confounding in observational studies, particularly in perinatal and life-course epidemiology. The recent JAMA Guide to Statistics and Methods by Dr Ahlqvist and colleagues emphasized a renewed need for this study across pregnancy, environmental, psychiatric, and neurological research and discussed its potential utility in strengthening causal inference.
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Response to PCSK9 Inhibition by LDL Receptor Function in Familial Hypercholesterolemia
https://jamanetwork.com/journals/jamacardiology/fullarticle/2847932
This nonrandomized clinical trial evaluates the reduction in low-density lipoprotein cholesterol (LDL-C) associated with proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibition by LDLR genotype in a large cohort of patients with heterozygous familial hypercholesterolemia.
https://jamanetwork.com/journals/jamacardiology/fullarticle/2847932
This nonrandomized clinical trial evaluates the reduction in low-density lipoprotein cholesterol (LDL-C) associated with proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibition by LDLR genotype in a large cohort of patients with heterozygous familial hypercholesterolemia.
Error in Author Surname
https://jamanetwork.com/journals/jamacardiology/fullarticle/2847930
In the Original Investigation titled “Rationale, Design, and Baseline Clinical Characteristics of the Ziltivekimab Cardiovascular Outcomes Trial: Interleukin-6 Inhibition and Atherosclerotic Event Rate Reduction,” published online December 10, 2025, and in the January 2026 issue, the spelling of author Anders Hvelplund’s surname was missing an “l.” This was amended in the byline, author contributions, and conflict of interest disclosures. This article has been corrected online.
https://jamanetwork.com/journals/jamacardiology/fullarticle/2847930
In the Original Investigation titled “Rationale, Design, and Baseline Clinical Characteristics of the Ziltivekimab Cardiovascular Outcomes Trial: Interleukin-6 Inhibition and Atherosclerotic Event Rate Reduction,” published online December 10, 2025, and in the January 2026 issue, the spelling of author Anders Hvelplund’s surname was missing an “l.” This was amended in the byline, author contributions, and conflict of interest disclosures. This article has been corrected online.
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Error in Byline
https://jamanetwork.com/journals/jamacardiology/fullarticle/2847928
The Original Investigation titled “Device-Assisted vs Standard Valsalva Maneuver for Terminating Supraventricular Tachycardia,” published on February 11, 2026, was corrected to fix a misspelling of an author’s first name in the byline; the correct spelling is Xin Zhao. This article was corrected online.
https://jamanetwork.com/journals/jamacardiology/fullarticle/2847928
The Original Investigation titled “Device-Assisted vs Standard Valsalva Maneuver for Terminating Supraventricular Tachycardia,” published on February 11, 2026, was corrected to fix a misspelling of an author’s first name in the byline; the correct spelling is Xin Zhao. This article was corrected online.
Timeliness of ATTR-CM Diagnosis in the Medicare Population
https://jamanetwork.com/journals/jamacardiology/fullarticle/2847925
This cohort study evaluates factors associated with time from incident heart failure to diagnosis of transthyretin cardiac amyloidosis among Medicare beneficiaries.
https://jamanetwork.com/journals/jamacardiology/fullarticle/2847925
This cohort study evaluates factors associated with time from incident heart failure to diagnosis of transthyretin cardiac amyloidosis among Medicare beneficiaries.
The Sodium Paradox in Decompensated Heart Failure
https://jamanetwork.com/journals/jamacardiology/fullarticle/2847923
This Viewpoint reviews evidence suggesting that controlled sodium chloride supplementation may facilitate decongestion in patients with decompensated heart failure.
https://jamanetwork.com/journals/jamacardiology/fullarticle/2847923
This Viewpoint reviews evidence suggesting that controlled sodium chloride supplementation may facilitate decongestion in patients with decompensated heart failure.
Dietary Guidelines for 2025-2030
https://jamanetwork.com/journals/jama/fullarticle/2848499
To the Editor The recent Perspective highlights the metabolic hazards (such as visceral adiposity) implicit in the recommendation from the 2025-2030 Dietary Guidelines for Americans (DGAs) to double protein intake. Yet, regarding stone disease, we see an important omission in the risk of nephrolithiasis.
https://jamanetwork.com/journals/jama/fullarticle/2848499
To the Editor The recent Perspective highlights the metabolic hazards (such as visceral adiposity) implicit in the recommendation from the 2025-2030 Dietary Guidelines for Americans (DGAs) to double protein intake. Yet, regarding stone disease, we see an important omission in the risk of nephrolithiasis.
Audio Highlights May 1, 2026
https://jamanetwork.com/journals/jama/fullarticle/2848688
Listen to the JAMA Editor’s Summary for an overview and discussion of the important articles appearing in JAMA.
https://jamanetwork.com/journals/jama/fullarticle/2848688
Listen to the JAMA Editor’s Summary for an overview and discussion of the important articles appearing in JAMA.
Apolipoprotein B May Improve CVD Risk Assessment in Younger Adults
https://jamanetwork.com/journals/jama/fullarticle/2848633
Using the lipid biomarker apolipoprotein B (apoB) may help improve cardiovascular disease risk assessment, particularly in younger adults, a recent study found.
https://jamanetwork.com/journals/jama/fullarticle/2848633
Using the lipid biomarker apolipoprotein B (apoB) may help improve cardiovascular disease risk assessment, particularly in younger adults, a recent study found.
CDC Reports Rise in Drug-Resistant Shigella Infections
https://jamanetwork.com/journals/jama/fullarticle/2848632
The US Centers for Disease Control and Prevention (CDC) reported that cases of extensively drug-resistant Shigella infections have increased significantly since 2015.
https://jamanetwork.com/journals/jama/fullarticle/2848632
The US Centers for Disease Control and Prevention (CDC) reported that cases of extensively drug-resistant Shigella infections have increased significantly since 2015.
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Most US Health Care Workers Vaccinated for Flu, Less Than Half for COVID-19
https://jamanetwork.com/journals/jama/fullarticle/2848631
The US Centers for Disease Control and Prevention (CDC) reported that most health care workers were vaccinated against influenza whereas less than half were vaccinated against COVID-19 during the 2024-2025 respiratory virus season.
https://jamanetwork.com/journals/jama/fullarticle/2848631
The US Centers for Disease Control and Prevention (CDC) reported that most health care workers were vaccinated against influenza whereas less than half were vaccinated against COVID-19 during the 2024-2025 respiratory virus season.
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HPV Vaccine Lowers Related Cancer Risk in Younger Males
https://jamanetwork.com/journals/jama/fullarticle/2848630
The 9-valent human papillomavirus (HPV) vaccine was associated with a lower risk of HPV-related cancers in adolescents and younger males, research published in JAMA Oncology found.
https://jamanetwork.com/journals/jama/fullarticle/2848630
The 9-valent human papillomavirus (HPV) vaccine was associated with a lower risk of HPV-related cancers in adolescents and younger males, research published in JAMA Oncology found.
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