Lipoprotein(a) Risk Variants and Culprit Coronary Thrombotic Lesions
https://jamanetwork.com/journals/jamacardiology/fullarticle/2849114
This cross-sectional study examines whether common lipoprotein(a) risk variants are associated with specific coronary plaque morphologies and thrombus characteristics in individuals of European ancestry with sudden coronary death.
https://jamanetwork.com/journals/jamacardiology/fullarticle/2849114
This cross-sectional study examines whether common lipoprotein(a) risk variants are associated with specific coronary plaque morphologies and thrombus characteristics in individuals of European ancestry with sudden coronary death.
Evidence-Based Imaging Pathway for Atrial Fibrillation Ablation
https://jamanetwork.com/journals/jamacardiology/fullarticle/2849113
To the Editor Periprocedural thromboembolism remains a significant complication of atrial fibrillation (AF) ablation, underscoring the importance of reliably excluding left atrial thrombus during procedural planning. Although transesophageal echocardiography (TEE) has traditionally been the reference standard for thrombus screening, its semi-invasive nature, requirement for sedation and esophageal intubation, and need for separate scheduling can create workflow challenges and patient discomfort. Intracardiac echocardiography (ICE) offers a practical alternative, but current guidance documents provide limited direction on how best to incorporate ICE into clinical practice.
https://jamanetwork.com/journals/jamacardiology/fullarticle/2849113
To the Editor Periprocedural thromboembolism remains a significant complication of atrial fibrillation (AF) ablation, underscoring the importance of reliably excluding left atrial thrombus during procedural planning. Although transesophageal echocardiography (TEE) has traditionally been the reference standard for thrombus screening, its semi-invasive nature, requirement for sedation and esophageal intubation, and need for separate scheduling can create workflow challenges and patient discomfort. Intracardiac echocardiography (ICE) offers a practical alternative, but current guidance documents provide limited direction on how best to incorporate ICE into clinical practice.
❤1
Evidence-Based Imaging Pathway for Atrial Fibrillation Ablation—Reply
https://jamanetwork.com/journals/jamacardiology/fullarticle/2849112
In Reply We thank George et al for their thoughtful comments regarding our randomized clinical trial comparing intracardiac echocardiography (ICE) and transesophageal echocardiography (TEE) for thrombus exclusion before atrial fibrillation (AF) ablation. Their letter appropriately highlights the importance of constructing imaging pathways that balance safety, procedural efficiency, and patient-centered considerations.
https://jamanetwork.com/journals/jamacardiology/fullarticle/2849112
In Reply We thank George et al for their thoughtful comments regarding our randomized clinical trial comparing intracardiac echocardiography (ICE) and transesophageal echocardiography (TEE) for thrombus exclusion before atrial fibrillation (AF) ablation. Their letter appropriately highlights the importance of constructing imaging pathways that balance safety, procedural efficiency, and patient-centered considerations.
Maternal Diabetes and Risk of Early-Onset Cardiovascular Diseases in Offspring
https://jamanetwork.com/journals/jamacardiology/fullarticle/2849111
This cohort study investigates whether maternal diabetes during pregnancy is associated with cardiovascular diseases in offspring and whether associations are mediated by adverse perinatal outcomes and early-life factors.
https://jamanetwork.com/journals/jamacardiology/fullarticle/2849111
This cohort study investigates whether maternal diabetes during pregnancy is associated with cardiovascular diseases in offspring and whether associations are mediated by adverse perinatal outcomes and early-life factors.
👍1
Diagnostic Drifts, Deceptions and Common Misses
https://jamanetwork.com/journals/jama/fullarticle/2849067
M. Pinson Neal, M.D., Columbia, Mo.
https://jamanetwork.com/journals/jama/fullarticle/2849067
M. Pinson Neal, M.D., Columbia, Mo.
Treatment of Idiopathic Acute Pancreatitis With Pancreas Divisum
https://jamanetwork.com/journals/jama/fullarticle/2849065
To the Editor Dr Coté and colleagues reported the Sphincterotomy for Acute Recurrent Pancreatitis (SHARP) trial, a multicenter, double-blind, sham-controlled randomized clinical trial evaluating endoscopic retrograde cholangiopancreatography (ERCP) with minor papillotomy for adults with unexplained acute recurrent pancreatitis and pancreas divisum. Recurrent acute pancreatitis beyond 30 days occurred in 34.7% of participants (26/75) in the ERCP with minor papillotomy group vs 43.8% of participants (32/73) in the sham ERCP group (adjusted hazard ratio, 0.83 [95% CI, 0.49-1.41]), whereas pancreatitis within 30 days occurred in 14.7% vs 8.2%, respectively.
https://jamanetwork.com/journals/jama/fullarticle/2849065
To the Editor Dr Coté and colleagues reported the Sphincterotomy for Acute Recurrent Pancreatitis (SHARP) trial, a multicenter, double-blind, sham-controlled randomized clinical trial evaluating endoscopic retrograde cholangiopancreatography (ERCP) with minor papillotomy for adults with unexplained acute recurrent pancreatitis and pancreas divisum. Recurrent acute pancreatitis beyond 30 days occurred in 34.7% of participants (26/75) in the ERCP with minor papillotomy group vs 43.8% of participants (32/73) in the sham ERCP group (adjusted hazard ratio, 0.83 [95% CI, 0.49-1.41]), whereas pancreatitis within 30 days occurred in 14.7% vs 8.2%, respectively.
Treatment of Idiopathic Acute Pancreatitis With Pancreas Divisum—Reply
https://jamanetwork.com/journals/jama/fullarticle/2849064
In Reply We thank Mr Liu and Mr Chen and colleagues for their comments regarding our randomized clinical trial evaluating ERCP with minor papillotomy in patients with pancreas divisum and unexplained acute recurrent pancreatitis. Liu asked whether anatomical features of impaired dorsal duct outflow modified the treatment effect. In prespecified subgroup analyses stratified by duct diameter or a santorinicele (in Figure 4), we did not find significant treatment × subgroup interactions for the primary outcome. As stated in the Discussion section, the study was not powered for these subgroups. Notably, the prevalence of a santorinicele was 12% using a mix of standard and secretin-enhanced magnetic resonance cholangiopancreatography prior to randomization, which is consistent with the radiology literature. In small santorinicele cohorts, outcomes of minor papillotomy for acute pancreatitis and divisum suggest persistent acute pancreatitis clinically, biochemically, or both in 20% to 30% of patients. Therefore, even though a dilated duct or santorinicele are suggestive of a stenotic orifice, it is unlikely that they are sufficient to ensure a clinically significant benefit of minor papillotomy.
https://jamanetwork.com/journals/jama/fullarticle/2849064
In Reply We thank Mr Liu and Mr Chen and colleagues for their comments regarding our randomized clinical trial evaluating ERCP with minor papillotomy in patients with pancreas divisum and unexplained acute recurrent pancreatitis. Liu asked whether anatomical features of impaired dorsal duct outflow modified the treatment effect. In prespecified subgroup analyses stratified by duct diameter or a santorinicele (in Figure 4), we did not find significant treatment × subgroup interactions for the primary outcome. As stated in the Discussion section, the study was not powered for these subgroups. Notably, the prevalence of a santorinicele was 12% using a mix of standard and secretin-enhanced magnetic resonance cholangiopancreatography prior to randomization, which is consistent with the radiology literature. In small santorinicele cohorts, outcomes of minor papillotomy for acute pancreatitis and divisum suggest persistent acute pancreatitis clinically, biochemically, or both in 20% to 30% of patients. Therefore, even though a dilated duct or santorinicele are suggestive of a stenotic orifice, it is unlikely that they are sufficient to ensure a clinically significant benefit of minor papillotomy.
Audio Highlights May 15, 2026
https://jamanetwork.com/journals/jama/fullarticle/2849343
Listen to the JAMA Editor’s Summary for an overview and discussion of the important articles appearing in JAMA.
https://jamanetwork.com/journals/jama/fullarticle/2849343
Listen to the JAMA Editor’s Summary for an overview and discussion of the important articles appearing in JAMA.
New Obesity Framework Ignites Debate
https://jamanetwork.com/journals/jama/fullarticle/2849294
This Medical News article discusses the critical response to a proposal to split obesity into preclinical and clinical categories and diagnose it using more than just body mass index (BMI).
https://jamanetwork.com/journals/jama/fullarticle/2849294
This Medical News article discusses the critical response to a proposal to split obesity into preclinical and clinical categories and diagnose it using more than just body mass index (BMI).
WHO Announces First Malaria Drug for Infants and New Rapid Diagnostic Tests
https://jamanetwork.com/journals/jama/fullarticle/2849301
The World Health Organization (WHO) prequalified the first malaria treatment developed specifically for newborns and young infants.
https://jamanetwork.com/journals/jama/fullarticle/2849301
The World Health Organization (WHO) prequalified the first malaria treatment developed specifically for newborns and young infants.
Paracervical Blocks for IUD Insertion Remain Underutilized
https://jamanetwork.com/journals/jama/fullarticle/2849300
Less than half of patients undergoing intrauterine device (IUD) insertion at a large academic health system received a paracervical block, according to a study published in JAMA Network Open.
https://jamanetwork.com/journals/jama/fullarticle/2849300
Less than half of patients undergoing intrauterine device (IUD) insertion at a large academic health system received a paracervical block, according to a study published in JAMA Network Open.
Life Expectancy and Years of Life Lost in a Large Contemporary Cohort of Individuals With COPD
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2848784
In this issue of JAMA Internal Medicine, Bhatt and colleagues use data from the National Heart, Lung, and Blood Institute (NHLBI) Pooled Cohorts Study to quantify life expectancy and years of life lost (YLL) from chronic obstructive pulmonary disease (COPD). Compared with persons without COPD, the authors report that YLL among persons with COPD were 1.9 years. Increasing severity of COPD markedly increased YLL: for Global Initiative for COPD (GOLD) stages 1 through 4 (higher stage indicates more severe disease), YLL was 0.7 years for stage 1, 2.6 years for stage 2, 5.1 years for stage 3, and 7.1 years for stage 4. Among persons with COPD, there were no differences in YLL between smokers and never-smokers or by sex. Depending on the severity of COPD, YLL were similar to or greater than the YLL lost for hypertension (2.7), diabetes (4.1), obesity (0.5), and smoking (5.5). These results corroborate previous epidemiologic research and clinical experience: COPD carries substantial public health burden and mortality increases with increasing disease severity.
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2848784
In this issue of JAMA Internal Medicine, Bhatt and colleagues use data from the National Heart, Lung, and Blood Institute (NHLBI) Pooled Cohorts Study to quantify life expectancy and years of life lost (YLL) from chronic obstructive pulmonary disease (COPD). Compared with persons without COPD, the authors report that YLL among persons with COPD were 1.9 years. Increasing severity of COPD markedly increased YLL: for Global Initiative for COPD (GOLD) stages 1 through 4 (higher stage indicates more severe disease), YLL was 0.7 years for stage 1, 2.6 years for stage 2, 5.1 years for stage 3, and 7.1 years for stage 4. Among persons with COPD, there were no differences in YLL between smokers and never-smokers or by sex. Depending on the severity of COPD, YLL were similar to or greater than the YLL lost for hypertension (2.7), diabetes (4.1), obesity (0.5), and smoking (5.5). These results corroborate previous epidemiologic research and clinical experience: COPD carries substantial public health burden and mortality increases with increasing disease severity.
Life Expectancy in Chronic Obstructive Pulmonary Disease
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2848783
This cohort study examines the association of chronic obstructive disease with life expectancy and whether this varies by severity of disease.
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2848783
This cohort study examines the association of chronic obstructive disease with life expectancy and whether this varies by severity of disease.
Musical Trick Alleviating Benign Essential Blepharospasm
https://jamanetwork.com/journals/jamaneurology/fullarticle/2849326
This case report describes a 61-year-old professional oboist whose symptoms of bilateral essential blepharospasm abated when she played the oboe or sung a musical arrangement.
https://jamanetwork.com/journals/jamaneurology/fullarticle/2849326
This case report describes a 61-year-old professional oboist whose symptoms of bilateral essential blepharospasm abated when she played the oboe or sung a musical arrangement.
Methodological Considerations for Quantile Aggregation in Alzheimer Disease Trials
https://jamanetwork.com/journals/jamaneurology/fullarticle/2849325
This study evaluates the quantile-aggregation method using both simulated data and publicly available Alzheimer disease randomized trial data.
https://jamanetwork.com/journals/jamaneurology/fullarticle/2849325
This study evaluates the quantile-aggregation method using both simulated data and publicly available Alzheimer disease randomized trial data.
Soccer Heading and Elevations in p-Tau217 and S100B Biomarkers
https://jamanetwork.com/journals/jamaneurology/fullarticle/2849324
This case-control study investigates if exposure to heading in amateur soccer is associated with changes in blood biomarkers of neural damage.
https://jamanetwork.com/journals/jamaneurology/fullarticle/2849324
This case-control study investigates if exposure to heading in amateur soccer is associated with changes in blood biomarkers of neural damage.
Digital Sleep-Wake Cycle Metrics and Dementia Prediction in Older Adults
https://jamanetwork.com/journals/jamaneurology/fullarticle/2849323
This cohort study investigates the association of sleep-wake cycle metrics with incident dementia and dementia prediction.
https://jamanetwork.com/journals/jamaneurology/fullarticle/2849323
This cohort study investigates the association of sleep-wake cycle metrics with incident dementia and dementia prediction.
Error in Figure 2
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2848659
In the Original Investigation titled “Holding vs Continuing GLP-1/GIP Agonists Before Upper Endoscopy: The OCULUS Randomized Clinical Trial,” published online March 16, 2026, and in the May 2026 issue, there was an error in Figure 2. The continue and hold figure labels were updated. This article was corrected online.
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2848659
In the Original Investigation titled “Holding vs Continuing GLP-1/GIP Agonists Before Upper Endoscopy: The OCULUS Randomized Clinical Trial,” published online March 16, 2026, and in the May 2026 issue, there was an error in Figure 2. The continue and hold figure labels were updated. This article was corrected online.
Artificial Intelligence and Bystander Cardiopulmonary Resuscitation
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2848658
Early administration of high-quality cardiopulmonary resuscitation (CPR) and defibrillation are the most effective interventions for out-of-hospital cardiac arrest (OHCA). Yet bystander CPR occurs in only half of OHCA cases, with lack of knowledge and training commonly cited as key barriers. Bridging this gap is a central challenge in resuscitation science.
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2848658
Early administration of high-quality cardiopulmonary resuscitation (CPR) and defibrillation are the most effective interventions for out-of-hospital cardiac arrest (OHCA). Yet bystander CPR occurs in only half of OHCA cases, with lack of knowledge and training commonly cited as key barriers. Bridging this gap is a central challenge in resuscitation science.
Acute Respiratory Infections in Primary Care
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2848657
Less is More
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2848657
Less is More