Sodium Bicarbonate for In-Hospital Cardiac Arrest Research Summary
https://jamanetwork.com/journals/jama/fullarticle/2850404
This study aimed to determine if sodium bicarbonate administered during in-hospital cardiac arrest increases the rate of sustained return of spontaneous circulation.
https://jamanetwork.com/journals/jama/fullarticle/2850404
This study aimed to determine if sodium bicarbonate administered during in-hospital cardiac arrest increases the rate of sustained return of spontaneous circulation.
Residual Myths in Feeding Critically Ill Children
https://jamanetwork.com/journals/jama/fullarticle/2850409
When children become critically ill and need invasive mechanical ventilation, making sure that they get the right amount of nutritional support is crucial, not only for the physiologic needs of delivering appropriate amounts of calories and protein, but also for the needs of the family, where feeding constitutes such an important part of childcare. Deliver too much enteral nutrition, and you may run the risk of complications, including aspiration or vomiting or gut diseases, such as necrotizing enterocolitis. Deliver too little enteral nutrition, and there may be inadequate calories contributing to delayed recovery.
https://jamanetwork.com/journals/jama/fullarticle/2850409
When children become critically ill and need invasive mechanical ventilation, making sure that they get the right amount of nutritional support is crucial, not only for the physiologic needs of delivering appropriate amounts of calories and protein, but also for the needs of the family, where feeding constitutes such an important part of childcare. Deliver too much enteral nutrition, and you may run the risk of complications, including aspiration or vomiting or gut diseases, such as necrotizing enterocolitis. Deliver too little enteral nutrition, and there may be inadequate calories contributing to delayed recovery.
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Gastric Residual Volume Assessment in Critically Ill Children
https://jamanetwork.com/journals/jama/fullarticle/2850408
This randomized clinical trial examines the effect of not routinely assessing gastric residual volume compared with assessments at least every 6 hours in children undergoing mechanical ventilation.
https://jamanetwork.com/journals/jama/fullarticle/2850408
This randomized clinical trial examines the effect of not routinely assessing gastric residual volume compared with assessments at least every 6 hours in children undergoing mechanical ventilation.
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Gastric Residual Volume Assessment in Critically Ill Children Research Summary
https://jamanetwork.com/journals/jama/fullarticle/2850407
The study evaluated whether not routinely assessing gastric residual volume (GRV), compared with regular assessment every 6 hours, affects mechanical ventilation duration, survival, and achievement of nutritional targets in critically ill children.
https://jamanetwork.com/journals/jama/fullarticle/2850407
The study evaluated whether not routinely assessing gastric residual volume (GRV), compared with regular assessment every 6 hours, affects mechanical ventilation duration, survival, and achievement of nutritional targets in critically ill children.
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Error in Byline
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2850244
In the Research Letter titled “Turnover and Burnout Among Family Physicians,” published online March 30, 2026, and in the May 2026 issue, there was an error in the byline. The spelling of the fourth author’s surname, Dr Peterson, was corrected. This article was corrected online.
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2850244
In the Research Letter titled “Turnover and Burnout Among Family Physicians,” published online March 30, 2026, and in the May 2026 issue, there was an error in the byline. The spelling of the fourth author’s surname, Dr Peterson, was corrected. This article was corrected online.
Error in the Text
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2850243
In the Research Letter titled “Ovarian Cysts in Polycystic Ovary Syndrome,” published online on May 11, 2026, there was an error in the text. In the second sentence of the Results section, the terms “with PCOS” and “without” were reversed. This article was corrected online.
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2850243
In the Research Letter titled “Ovarian Cysts in Polycystic Ovary Syndrome,” published online on May 11, 2026, there was an error in the text. In the second sentence of the Results section, the terms “with PCOS” and “without” were reversed. This article was corrected online.
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Error in Table 1 and Results
https://jamanetwork.com/journals/jamaneurology/fullarticle/2850386
The Original Investigation titled “Efficacy and Safety of Vemircopan in Generalized Myasthenia Gravis: A Randomized Clinical Trial,” published on April 27, 2026, was corrected to fix errors in percentage values reported in Table 1 and the Results section. In Table 1, in the placebo group, the correct percentage values for the Hispanic or Latino participant and the participant with unknown ethnicity are 4%. This article was corrected online.
https://jamanetwork.com/journals/jamaneurology/fullarticle/2850386
The Original Investigation titled “Efficacy and Safety of Vemircopan in Generalized Myasthenia Gravis: A Randomized Clinical Trial,” published on April 27, 2026, was corrected to fix errors in percentage values reported in Table 1 and the Results section. In Table 1, in the placebo group, the correct percentage values for the Hispanic or Latino participant and the participant with unknown ethnicity are 4%. This article was corrected online.
Error in Abstract Results
https://jamanetwork.com/journals/jamaneurology/fullarticle/2850385
In the Original Investigation titled “Mechanical Thrombectomy and Final Infarct Volume in Medium or Distal Vessel Occlusion Stroke: A Post Hoc Analysis of a Randomized Clinical Trial,” published April 20, 2026, there was an error in the Abstract Results. The text should have stated that the median (IQR) time to maximum more than 6 seconds (Tmax6) volume was 34.0 (20.0-50.0) mL instead of stating that the median (IQR) time to maximum less than 6 seconds (Tmax6) volume was 34.0 (20.0-50.0) mL.
https://jamanetwork.com/journals/jamaneurology/fullarticle/2850385
In the Original Investigation titled “Mechanical Thrombectomy and Final Infarct Volume in Medium or Distal Vessel Occlusion Stroke: A Post Hoc Analysis of a Randomized Clinical Trial,” published April 20, 2026, there was an error in the Abstract Results. The text should have stated that the median (IQR) time to maximum more than 6 seconds (Tmax6) volume was 34.0 (20.0-50.0) mL instead of stating that the median (IQR) time to maximum less than 6 seconds (Tmax6) volume was 34.0 (20.0-50.0) mL.
Clinical Conversations and Cognitive Impairment
https://jamanetwork.com/journals/jamaneurology/fullarticle/2850384
The availability of disease-modifying treatments for Alzheimer disease and ongoing trials for other causes of dementia have made the early detection of cognitive impairment a priority. Primary care clinicians are ideally positioned to aid in early diagnosis, but only about 8% of expected mild cognitive impairment cases are identified in that setting. This gap is driven by numerous factors, including restricted time, the number of co-occurring needs, and the perception that existing assessment tools are unhelpful. One potential solution is to embed cognitive screening into existing clinical workflows; researchers have increasingly turned to speech as a potential passive screening method. In this issue of JAMA Neurology, Colonel et al report the development and external validation of machine learning models that use acoustic features extracted from routine primary care conversations to screen for cognitive impairment. If matured, this approach could meaningfully change how and when cognitive decline is detected.
https://jamanetwork.com/journals/jamaneurology/fullarticle/2850384
The availability of disease-modifying treatments for Alzheimer disease and ongoing trials for other causes of dementia have made the early detection of cognitive impairment a priority. Primary care clinicians are ideally positioned to aid in early diagnosis, but only about 8% of expected mild cognitive impairment cases are identified in that setting. This gap is driven by numerous factors, including restricted time, the number of co-occurring needs, and the perception that existing assessment tools are unhelpful. One potential solution is to embed cognitive screening into existing clinical workflows; researchers have increasingly turned to speech as a potential passive screening method. In this issue of JAMA Neurology, Colonel et al report the development and external validation of machine learning models that use acoustic features extracted from routine primary care conversations to screen for cognitive impairment. If matured, this approach could meaningfully change how and when cognitive decline is detected.
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Low Back Pain: A Review
https://jamanetwork.com/journals/jama/fullarticle/2850593
This narrative review discusses the pathophysiology, epidemiology, clinical presentation, diagnosis, and treatment of nonspecific low back pain.
https://jamanetwork.com/journals/jama/fullarticle/2850593
This narrative review discusses the pathophysiology, epidemiology, clinical presentation, diagnosis, and treatment of nonspecific low back pain.
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Specialty and Geography of Medicare’s New Residency Positions
https://jamanetwork.com/journals/jama/fullarticle/2850454
This cross-sectional study reports on the changes in allocation of resident training spots by specialties and rurality and assesses whether newly allocated positions meet the targets set by Consolidated Appropriations Acts of 2021 and 2023.
https://jamanetwork.com/journals/jama/fullarticle/2850454
This cross-sectional study reports on the changes in allocation of resident training spots by specialties and rurality and assesses whether newly allocated positions meet the targets set by Consolidated Appropriations Acts of 2021 and 2023.
A Book for Medical Device Patents
https://jamanetwork.com/journals/jama/fullarticle/2850453
To the Editor Dr Simon and colleagues’ Viewpoint proposes the creation of a Yellow Book for medical device patent transparency. The concept of a publicly accessible device patent database is compelling and could meaningfully advance research, regulatory oversight, and market transparency. However, I respectfully suggest reconsideration of the proposed title.
https://jamanetwork.com/journals/jama/fullarticle/2850453
To the Editor Dr Simon and colleagues’ Viewpoint proposes the creation of a Yellow Book for medical device patent transparency. The concept of a publicly accessible device patent database is compelling and could meaningfully advance research, regulatory oversight, and market transparency. However, I respectfully suggest reconsideration of the proposed title.
Prone Positioning in Viral Bronchiolitis—Back to the Back?
https://jamanetwork.com/journals/jama/fullarticle/2850559
Acute viral bronchiolitis is the most common diagnosis in US children’s hospitals, and respiratory failure is the costliest diagnosis across all pediatric acute care. Despite the prevalence of this condition and its impact on children, families, and health systems, evidence-based treatments for acute bronchiolitis in hospitalized children are few and guidelines largely recommend against most interventions. In this issue of JAMA, Baudin and colleagues for the PROPOSITIS Investigators evaluated a promising but understudied option: prone positioning. In a well-designed randomized clinical trial (RCT) conducted from 2021 to 2023, the authors enrolled 451 infants younger than 6 months with viral bronchiolitis who were receiving high-flow nasal cannula (HFNC) support. The primary end point of the study was escalation of care to noninvasive or invasive positive pressure ventilation (notably, only 3 children in the cohort were intubated). The primary intention-to-treat analysis did not reach statistical significance—with an odds ratio for escalation with prone positioning of 0.66 (95% CI, 0.40-1.07)—which was surprising given that their pilot physiological study suggested that prone positioning either improves effort of breathing or has negligible impact.
https://jamanetwork.com/journals/jama/fullarticle/2850559
Acute viral bronchiolitis is the most common diagnosis in US children’s hospitals, and respiratory failure is the costliest diagnosis across all pediatric acute care. Despite the prevalence of this condition and its impact on children, families, and health systems, evidence-based treatments for acute bronchiolitis in hospitalized children are few and guidelines largely recommend against most interventions. In this issue of JAMA, Baudin and colleagues for the PROPOSITIS Investigators evaluated a promising but understudied option: prone positioning. In a well-designed randomized clinical trial (RCT) conducted from 2021 to 2023, the authors enrolled 451 infants younger than 6 months with viral bronchiolitis who were receiving high-flow nasal cannula (HFNC) support. The primary end point of the study was escalation of care to noninvasive or invasive positive pressure ventilation (notably, only 3 children in the cohort were intubated). The primary intention-to-treat analysis did not reach statistical significance—with an odds ratio for escalation with prone positioning of 0.66 (95% CI, 0.40-1.07)—which was surprising given that their pilot physiological study suggested that prone positioning either improves effort of breathing or has negligible impact.
Prone Positioning in Infants With Acute Bronchiolitis
https://jamanetwork.com/journals/jama/fullarticle/2850558
This randomized trial assesses the effect of prone positioning in infants with moderate to severe bronchiolitis receiving high-flow nasal cannula (HFNC) support on the need for escalation of care to noninvasive or invasive ventilation within 72 hours.
https://jamanetwork.com/journals/jama/fullarticle/2850558
This randomized trial assesses the effect of prone positioning in infants with moderate to severe bronchiolitis receiving high-flow nasal cannula (HFNC) support on the need for escalation of care to noninvasive or invasive ventilation within 72 hours.
Prone Positioning in Infants With Acute Bronchiolitis Research Summary
https://jamanetwork.com/journals/jama/fullarticle/2850557
This study aimed to determine if prone positioning for infants aged 6 months or younger with moderate to severe acute bronchiolitis receiving high-flow nasal cannula support (HFNC) reduces escalation of care to noninvasive or invasive ventilation.
https://jamanetwork.com/journals/jama/fullarticle/2850557
This study aimed to determine if prone positioning for infants aged 6 months or younger with moderate to severe acute bronchiolitis receiving high-flow nasal cannula support (HFNC) reduces escalation of care to noninvasive or invasive ventilation.
Error in Correction Notice Reference
https://jamanetwork.com/journals/jamacardiology/fullarticle/2850512
The correction notice titled “Error in Byline,” published on January 29, 2025, was corrected to fix an error in the reference; the correct journal is JAMA Cardiology, and the correct doi is 10.1001/jamacardio.2024.2824. This article was corrected online.
https://jamanetwork.com/journals/jamacardiology/fullarticle/2850512
The correction notice titled “Error in Byline,” published on January 29, 2025, was corrected to fix an error in the reference; the correct journal is JAMA Cardiology, and the correct doi is 10.1001/jamacardio.2024.2824. This article was corrected online.
Cardiac Tamponade Captured in Dual-Phase Computed Tomography
https://jamanetwork.com/journals/jamacardiology/fullarticle/2850511
This case report discusses instantaneous cardiac tamponade due to hemorrhagic pericardial effusion captured on computed tomography imaging in a previously hemodynamically stable patient with acute chest pain.
https://jamanetwork.com/journals/jamacardiology/fullarticle/2850511
This case report discusses instantaneous cardiac tamponade due to hemorrhagic pericardial effusion captured on computed tomography imaging in a previously hemodynamically stable patient with acute chest pain.
Audio Highlights June 18, 2026
https://jamanetwork.com/journals/jama/fullarticle/2850779
Listen to the JAMA Editor’s Summary for an overview and discussion of the important articles appearing in JAMA.
https://jamanetwork.com/journals/jama/fullarticle/2850779
Listen to the JAMA Editor’s Summary for an overview and discussion of the important articles appearing in JAMA.
Postoperative Delirium May Predict Long-Term Cognitive Decline
https://jamanetwork.com/journals/jama/fullarticle/2850666
Delirium after surgery may be a strong predictor of long-term cognitive decline in older adults independent of illness or frailty, a recent study suggests.
https://jamanetwork.com/journals/jama/fullarticle/2850666
Delirium after surgery may be a strong predictor of long-term cognitive decline in older adults independent of illness or frailty, a recent study suggests.