Insufficient Sleep Among US Adolescents—Reply
https://jamanetwork.com/journals/jama/fullarticle/2850723

In Reply In his thoughtful comments on our Research Letter examining trends in insufficient sleep among US adolescents, Dr White raises an important point regarding the comparability of the 2021 and 2023 screen time measures with those used in prior years (2007-2019).

Superficial Siderosis and a Spinal Cord Cleft
https://jamanetwork.com/journals/jamaneurology/fullarticle/2850852

This case report describes a 71-year-old woman presenting with altered speech, gait difficulties, and hearing loss diagnosed with infratentorial superficial siderosis and a thoracic spinal cord cleft.

Prior Traumatic Brain Injury and Alzheimer Disease Blood Biomarkers
https://jamanetwork.com/journals/jamaneurology/fullarticle/2850851

This diagnostic study investigates the accuracy of the plasma phosphorylated tau 217 (p-tau217)/amyloid-β 42 (Aβ42) ratio test for detecting amyloid–positron emission tomography positivity for an Alzheimer disease diagnosis in older veterans with and without a history of traumatic brain injury.

Novel Autoantibody Discovery in Encephalitis
https://jamanetwork.com/journals/jamaneurology/fullarticle/2850850

This Viewpoint describes a plateau in the discovery of clinically meaningful autoantibodies in autoimmune encephalitis (AE) and suggests efforts that are likely to offer greater benefits to patients living with AE.

In Defense of Novel Autoantibody Discovery
https://jamanetwork.com/journals/jamaneurology/fullarticle/2850849

This Viewpoint discusses the discovery of numerous neuronal autoantibodies and how autoimmune encephalitis is diagnosed and treated.

Wide-Complex Tachycardia With Diffuse ST-Segment Elevation
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2850982

This case report describes the electrocardiogram findings of an older adult man with acute chest pain, dyspnea, and altered consciousness.

Texting in Health Care
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2850974

This Viewpoint offers strategies to help ensure that health care text messaging remains impactful rather than intrusive for patients.

Expanding Access to Mindfulness for Pain
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2850981

Back pain is among the most widespread and disabling conditions treated in primary care in the US, yet its management remains challenging and costly. Untreated and undertreated chronic low back pain (cLBP) has left many patients without adequate relief, contributing to the overprescribing and overuse of opioids and other medications, despite known adverse effects and risks of dependence and overdose. Guidelines for treating cLBP now recommend evidence-based nonpharmacologic pain treatments, including complementary and integrative health approaches, of which mindfulness-based interventions are among the most popular. Mindfulness-based interventions are especially well suited for treating cLBP, with evidence that they can improve common co-occurring conditions, such as depression, anxiety, and sleep disorders, that can contribute to and exacerbate pain. However, mindfulness and other complementary and integrative health approaches remain underused, partially because of the difficulties in integrating them into usual clinical practice.

Acetaminophen Use in Pregnancy and Neurodevelopmental Outcomes
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2850980

In September 2025, the US administration held a press conference stating that its ongoing investigation into the causes of autism had identified maternal use of acetaminophen (paracetamol) during pregnancy as a potential causal factor. This was concerning given that acetaminophen is among the most used medications in pregnancy for the management of pain and fever, in part because alternative options are limited or contraindicated (eg, nonsteroidal anti-inflammatory medications and opioids).

Health Equity: JAMA Internal Medicine Call for Papers
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2851086

Research on health differences by social class and economic status dates back to the mid-19th century. Early European publications examined differences in health by social class; then, during the next 100 years, the US produced the bulk of the evidence describing persistent and substantive differences in health across a broader range of social factors. During this descriptive period, scientists and clinicians came to realize that the differences noted in health care settings resulted from an array of structural, environmental, and social factors that spanned well beyond individual patients or the health care system. These broader factors are directly related to historical and current systemic inequities disadvantaging multiple population groups. The US is a fitting setting for this descriptive work, given its particularly stark social and economic inequities despite unparalleled national spending on research and health care. More recently, this research has evolved to explore underlying mechanisms of inequities and to test interventions to improve outcomes. This evolution has also marked a shift in nomenclature from health disparities (descriptive) to health equity (advancing health for all) research. However, despite progress during the last 75 years in the US, research in this field has continued to focus overwhelmingly on describing the number and scope of health inequities and defining the groups most adversely affected, at times relying heavily on conjectures about underlying etiology framed by the sociopolitical context.

Football-Specific On-Pitch Concussion Assessment Protocol
https://jamanetwork.com/journals/jamaneurology/fullarticle/2851047

This Special Communication discusses the development of a football-specific, standardized on-pitch concussion assessment protocol informed by research evidence and expert opinion using an international consensus process and steering committee deliberation.

Swinging Heart and an Intrapericardial Nodule in a 52-Year-Old Male
https://jamanetwork.com/journals/jamacardiology/fullarticle/2850831

This case report discusses a rare cause of cardiac tamponade in a male patient aged 52 years who presented with progressive dyspnea, chest pain, and palpitations over 3 months.

Late Complication in Cardiac Sarcoidosis in a 40-Year-Old Female
https://jamanetwork.com/journals/jamacardiology/fullarticle/2850830

This case report discusses a rare complication in a female patient in her 40s with cardiac sarcoidosis who underwent repeated ventricular tachycardia ablations.

PCSK9 Inhibitor Price Reductions and Medicare Part D Utilization and Spending
https://jamanetwork.com/journals/jamacardiology/fullarticle/2850829

This cross-sectional study evaluates price reductions and subsequent Medicare Part D utilization and spending for proprotein convertase subtilisin/kexin type 9 (PCSK9) inhibitors.

Tofersen Distribution in the Central Nervous System of SOD1 -ALS Autopsy Tissue Donors
https://jamanetwork.com/journals/jamaneurology/fullarticle/2850993

This autopsy tissue case series determines the tissue distribution of tofersen and provides estimates of SOD1 reduction in human somatic motor systems tissues among deceased patients with SOD1–amyotrophic lateral sclerosis (SOD1-ALS).

The Machine Is Just as Loud
https://jamanetwork.com/journals/jamaneurology/fullarticle/2850992

This essay describes the author’s experience with postseizure workups and scans and the protection that she felt was attached to professional status on both occasions.

Point-of-Care Polymerase Chain Reaction Testing for Respiratory Viruses Among Nursing Home Residents to Reduce Hospital Transfers
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2850887

In this issue of JAMA Internal Medicine, Kandel et al share the results of a cluster randomized trial leveraging point-of-care polymerase chain reaction (PCR) testing in nursing homes (NHs) to improve early detection of infections caused by SARS-CoV-2, influenza, and respiratory syncytial virus. While number or size of outbreaks and mortality did not differ, the proportion of residents transferred to acute care for confirmed and suspected viral respiratory infections decreased at intervention sites compared with control sites. The authors determined that this would result in 4 fewer transfers per 100 beds during the winter and spring respiratory virus seasons, a substantial benefit for NH residents.

Potential Biases in Assessment of Smallest Worthwhile Difference for Statin Therapy
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2850886

To the Editor In their Research Letter, Luo et al attempted to define the smallest worthwhile difference (SWD) that would justify statin therapy for primary prevention of atherosclerotic cardiovascular disease (ASCVD) from the patient perspective. Interestingly, they found that the SWD for most patients differed from current guideline recommendations. Moreover, the variability in SWD observed among individuals underscores the importance of incorporating values and preferences into evidence-based clinical decision-making.

Potential Biases in Assessment of Smallest Worthwhile Difference for Statin Therapy—Reply
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2850885

In Reply We thank Fischer for his thoughtful comments regarding our Research Letter. First, he states that the smallest worthwhile difference (SWD) should be independent of baseline risk because benefits and harms must be weighed in absolute terms. We agree that clinical decisions should be based on absolute effects, which is why we presented participants with absolute risk reductions using graphical displays and questions framed as, “If the risk is reduced from X% to Y%, would you accept treatment?” (eMethods in Supplement 1), making confusion with relative risk reduction unlikely. However, this does not necessarily imply that SWD should be constant across baseline risks.

Respiratory Outbreak Mitigation With Point-of-Care Testing in Long-Term Care
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2850884

This cluster randomized trial examines the effect of an on-site point-of-care respiratory multiplex polymerase chain reaction instrument on outbreaks of SARS-CoV-2, influenza, and respiratory syncytial virus in nursing homes.