Colorectal Cancer and Mortality Among Older Adults With vs Without Adenoma on Prior Colonoscopy
https://jamanetwork.com/journals/jama/fullarticle/2852631
To the Editor A recent study provided valuable competing risk data for surveillance decisions in adults aged 75 years or older with prior colonoscopy. In their cohort, 10-year colorectal cancer incidence was higher among individuals with prior adenoma than among those without adenoma, but the absolute difference was small (1.1% vs 0.7%). Colorectal cancer mortality was similarly low, whereas noncolorectal cancer death was approximately 48%, and increased to 82% among those with severe frailty. The accompanying Editorial appropriately framed these findings as a challenge to reflexive surveillance in late life.
https://jamanetwork.com/journals/jama/fullarticle/2852631
To the Editor A recent study provided valuable competing risk data for surveillance decisions in adults aged 75 years or older with prior colonoscopy. In their cohort, 10-year colorectal cancer incidence was higher among individuals with prior adenoma than among those without adenoma, but the absolute difference was small (1.1% vs 0.7%). Colorectal cancer mortality was similarly low, whereas noncolorectal cancer death was approximately 48%, and increased to 82% among those with severe frailty. The accompanying Editorial appropriately framed these findings as a challenge to reflexive surveillance in late life.
Colorectal Cancer and Mortality Among Older Adults With vs Without Adenoma on Prior Colonoscopy
https://jamanetwork.com/journals/jama/fullarticle/2852630
To the Editor With regard to colorectal cancer surveillance in older adults, a recent study presented compelling data highlighting that the risk of noncolorectal cancer death far exceeds the risk of colorectal cancer in adults aged 75 years or older, even among those with a prior adenoma. This finding is important for shared decision-making and supports the deescalation of surveillance in this population. However, we wish to raise 2 points regarding the interpretation of these results that are highly relevant to current clinical practice.
https://jamanetwork.com/journals/jama/fullarticle/2852630
To the Editor With regard to colorectal cancer surveillance in older adults, a recent study presented compelling data highlighting that the risk of noncolorectal cancer death far exceeds the risk of colorectal cancer in adults aged 75 years or older, even among those with a prior adenoma. This finding is important for shared decision-making and supports the deescalation of surveillance in this population. However, we wish to raise 2 points regarding the interpretation of these results that are highly relevant to current clinical practice.
Worsening Spastic Paraparesis After Lumbar Puncture
https://jamanetwork.com/journals/jamaneurology/fullarticle/2852812
This case report describes a patient with a history of progressive sensory disturbance whose lumbar puncture resulted in acute neurological deterioration due to positional cord compression.
https://jamanetwork.com/journals/jamaneurology/fullarticle/2852812
This case report describes a patient with a history of progressive sensory disturbance whose lumbar puncture resulted in acute neurological deterioration due to positional cord compression.
Management of Exacerbations and Rescue Therapy
https://jamanetwork.com/journals/jamaneurology/fullarticle/2852811
This prespecified analysis of a randomized clinical trial evaluates the effect of inebilizumab on exacerbations of generalized myasthenia gravis, including the need for rescue therapy.
https://jamanetwork.com/journals/jamaneurology/fullarticle/2852811
This prespecified analysis of a randomized clinical trial evaluates the effect of inebilizumab on exacerbations of generalized myasthenia gravis, including the need for rescue therapy.
Plasma Biomarkers for Neocortical Tau Burden
https://jamanetwork.com/journals/jamaneurology/fullarticle/2852810
This study attempts to develop and validate a multiprotein plasma panel to improve identification of neocortical tau pathology beyond phosphorylated tau-217 alone.
https://jamanetwork.com/journals/jamaneurology/fullarticle/2852810
This study attempts to develop and validate a multiprotein plasma panel to improve identification of neocortical tau pathology beyond phosphorylated tau-217 alone.
Vutrisiran Treatment and Cardiac and Amyloid Changes on MRI
https://jamanetwork.com/journals/jamacardiology/fullarticle/2852859
This cohort study investigates if vutrisiran treatment was associated with longitudinal changes in cardiac structure, function, and amyloid burden in patients with transthyretin amyloid cardiomyopathy who were assessed with cardiovascular magnetic resonance imaging (MRI).
https://jamanetwork.com/journals/jamacardiology/fullarticle/2852859
This cohort study investigates if vutrisiran treatment was associated with longitudinal changes in cardiac structure, function, and amyloid burden in patients with transthyretin amyloid cardiomyopathy who were assessed with cardiovascular magnetic resonance imaging (MRI).
Toward Precision Antiplatelet Therapy After Coronary Artery Bypass Grafting
https://jamanetwork.com/journals/jamacardiology/fullarticle/2852858
To the Editor We read with great interest the recent Viewpoint by Sandner et al proposing a mechanistic framework to guide antiplatelet therapy after coronary artery bypass grafting (CABG). The authors argue that the intensity and duration of dual antiplatelet therapy (DAPT) should align with the temporal evolution of thrombotic risk, which is highest in the early postoperative phase and declines thereafter.
https://jamanetwork.com/journals/jamacardiology/fullarticle/2852858
To the Editor We read with great interest the recent Viewpoint by Sandner et al proposing a mechanistic framework to guide antiplatelet therapy after coronary artery bypass grafting (CABG). The authors argue that the intensity and duration of dual antiplatelet therapy (DAPT) should align with the temporal evolution of thrombotic risk, which is highest in the early postoperative phase and declines thereafter.
Toward Precision Antiplatelet Therapy After Coronary Artery Bypass Grafting—Reply
https://jamanetwork.com/journals/jamacardiology/fullarticle/2852857
In Reply We appreciate the insightful studies reported by Camera and Tremoli on the possibility of additional tailoring of intensity and duration of antithrombotic therapy after coronary artery bypass graft surgery (CABG) based on other biological determinants of the thrombotic risk that explain interindividual variability in the response to antiplatelet therapy.
https://jamanetwork.com/journals/jamacardiology/fullarticle/2852857
In Reply We appreciate the insightful studies reported by Camera and Tremoli on the possibility of additional tailoring of intensity and duration of antithrombotic therapy after coronary artery bypass graft surgery (CABG) based on other biological determinants of the thrombotic risk that explain interindividual variability in the response to antiplatelet therapy.
Error in Title
https://jamanetwork.com/journals/jamaneurology/fullarticle/2852959
The Original Investigation titled “Management of Exacerbations and Rescue Therapy in the Phase 3 Myasthenia Gravis Inebilizumab Trial: A Prespecified Analysis of a Randomized Clinical Trial,” published online on August 10, 2026, was corrected to update the title from “Management of Exacerbations and Rescue Therapy: A Prespecified Analysis of the Phase 3 Myasthenia Gravis Inebilizumab Randomized Clinical Trial.” This article was corrected online.
https://jamanetwork.com/journals/jamaneurology/fullarticle/2852959
The Original Investigation titled “Management of Exacerbations and Rescue Therapy in the Phase 3 Myasthenia Gravis Inebilizumab Trial: A Prespecified Analysis of a Randomized Clinical Trial,” published online on August 10, 2026, was corrected to update the title from “Management of Exacerbations and Rescue Therapy: A Prespecified Analysis of the Phase 3 Myasthenia Gravis Inebilizumab Randomized Clinical Trial.” This article was corrected online.
Non–US-Born Physicians in the US Internal Medicine Workforce
https://jamanetwork.com/journals/jama/fullarticle/2852745
This study estimates the share of US-born and non–US-born US medical graduates (USMGs) and international medical graduates (IMGs) in the US internal medicine workforce, as well as the share of underserved patients cared for by these physicians.
https://jamanetwork.com/journals/jama/fullarticle/2852745
This study estimates the share of US-born and non–US-born US medical graduates (USMGs) and international medical graduates (IMGs) in the US internal medicine workforce, as well as the share of underserved patients cared for by these physicians.
Diagnosis of Celiac Disease
https://jamanetwork.com/journals/jama/fullarticle/2852746
This Insights discusses the diagnosis of celiac disease, including biopsy confirmation vs serology-based diagnosis, in children and adults.
https://jamanetwork.com/journals/jama/fullarticle/2852746
This Insights discusses the diagnosis of celiac disease, including biopsy confirmation vs serology-based diagnosis, in children and adults.
Total Intravenous vs Volatile Inhalational Anesthesia for Major Noncardiac Surgery Research Summary
https://jamanetwork.com/journals/jama/fullarticle/2852737
This trial examined whether general anesthesia maintenance with total intravenous anesthesia (TIVA) improves patient outcomes compared with volatile-based inhalational anesthesia among adults aged ≥50 years undergoing major elective noncardiac surgery.
https://jamanetwork.com/journals/jama/fullarticle/2852737
This trial examined whether general anesthesia maintenance with total intravenous anesthesia (TIVA) improves patient outcomes compared with volatile-based inhalational anesthesia among adults aged ≥50 years undergoing major elective noncardiac surgery.
“Nevus”: The Body as Text in Poetry
https://jamanetwork.com/journals/jama/fullarticle/2852738
The body as text is among the richest and most enduring conceits in poetry—the idea that flesh, skin, and breath can be read, written upon, or themselves constitute a kind of language. Poets as diverse as Sappho, Walt Whitman, Pablo Neruda, Ellen Bass, and Patricia Smith have imagined the corporeal body as a form of expression or as a page upon which experience is inscribed. Physical attributes can become directions or landmarks on a map; anatomical features can be construed as metaphors; scars and wrinkles can be refigured as punctuation marks. It is unsurprising, then, that poetry written in response to medical experiences specifically should express such themes. Such is the case with “Nevus,” a poem in which the speaker sees his childhood retold in the various lesions his dermatologist assesses as she examines his skin. “She moves from mole to mole,/her dermatoscope hovering/above the surface of my pink planet,” it begins, immediately comparing the physical body with an entire world ready to be charted and read. Individual nevi come alive, “a small brain” or a cultivator of “two delicate hairs/as pets on my chest,” with their own mini narratives. The larger story of the speaker’s carefree childhood bodysurfing and suffering sunburns is recorded in a couple of more concerning moles. When the speaker returns to have these burned off, embodied memories are evocatively lost and yet remembered, much like a fire in a library can revise history, “all that fun so long ago,/the past just a small plume of ash.”
https://jamanetwork.com/journals/jama/fullarticle/2852738
The body as text is among the richest and most enduring conceits in poetry—the idea that flesh, skin, and breath can be read, written upon, or themselves constitute a kind of language. Poets as diverse as Sappho, Walt Whitman, Pablo Neruda, Ellen Bass, and Patricia Smith have imagined the corporeal body as a form of expression or as a page upon which experience is inscribed. Physical attributes can become directions or landmarks on a map; anatomical features can be construed as metaphors; scars and wrinkles can be refigured as punctuation marks. It is unsurprising, then, that poetry written in response to medical experiences specifically should express such themes. Such is the case with “Nevus,” a poem in which the speaker sees his childhood retold in the various lesions his dermatologist assesses as she examines his skin. “She moves from mole to mole,/her dermatoscope hovering/above the surface of my pink planet,” it begins, immediately comparing the physical body with an entire world ready to be charted and read. Individual nevi come alive, “a small brain” or a cultivator of “two delicate hairs/as pets on my chest,” with their own mini narratives. The larger story of the speaker’s carefree childhood bodysurfing and suffering sunburns is recorded in a couple of more concerning moles. When the speaker returns to have these burned off, embodied memories are evocatively lost and yet remembered, much like a fire in a library can revise history, “all that fun so long ago,/the past just a small plume of ash.”
A Review of Endometrial Cancer
https://jamanetwork.com/journals/jama/fullarticle/2852744
To the Editor A recent Review offered a comprehensive overview of endometrial cancer, highlighting the emerging significance of molecular classification in informing prognosis and treatment, which reflects the growing role of molecular classification in clinical care. Nevertheless, the practical implementation of molecular classification was inadequately explored. Access to comprehensive molecular testing is inconsistent across health care systems. Even in high-resource settings, the availability of assays such as polymerase epsilon (POLE) sequencing is variable and result interpretation lacks standardization. These challenges are more pronounced in low-resource settings, resulting in a disparity between theoretical optimal care and real-world clinical practice.
https://jamanetwork.com/journals/jama/fullarticle/2852744
To the Editor A recent Review offered a comprehensive overview of endometrial cancer, highlighting the emerging significance of molecular classification in informing prognosis and treatment, which reflects the growing role of molecular classification in clinical care. Nevertheless, the practical implementation of molecular classification was inadequately explored. Access to comprehensive molecular testing is inconsistent across health care systems. Even in high-resource settings, the availability of assays such as polymerase epsilon (POLE) sequencing is variable and result interpretation lacks standardization. These challenges are more pronounced in low-resource settings, resulting in a disparity between theoretical optimal care and real-world clinical practice.
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From Breakthrough to Follow-Through—A Public Health Agenda for AI
https://jamanetwork.com/journals/jama/fullarticle/2852950
This Viewpoint discusses the role of artificial intelligence (AI) in ensuring that patients eligible for highly effective interventions are identified and receive them.
https://jamanetwork.com/journals/jama/fullarticle/2852950
This Viewpoint discusses the role of artificial intelligence (AI) in ensuring that patients eligible for highly effective interventions are identified and receive them.
Stereotactic Body Radiotherapy vs Moderately Hypofractionated IMRT for Localized Intermediate-Risk Prostate Cancer Research Summary
https://jamanetwork.com/journals/jama/fullarticle/2852843
The objective of this study was to assess whether stereotactic body radiotherapy (SBRT) was superior to moderately hypofractionated intensity-modulated radiation therapy (MH-IMRT) for urinary and bowel quality of life and disease-free survival in patients with localized intermediate-risk prostate cancer.
https://jamanetwork.com/journals/jama/fullarticle/2852843
The objective of this study was to assess whether stereotactic body radiotherapy (SBRT) was superior to moderately hypofractionated intensity-modulated radiation therapy (MH-IMRT) for urinary and bowel quality of life and disease-free survival in patients with localized intermediate-risk prostate cancer.
Optimizing the Therapeutic Ratio in Prostate Radiation Therapy
https://jamanetwork.com/journals/jama/fullarticle/2852853
Prostate cancer has long served as a fertile ground for innovation in cancer therapy. Compared with many other malignancies, localized prostate cancer occupies a unique clinical space. Although the incidence of new diagnoses is high, prostate cancer often follows an indolent natural history, resulting in a low risk of prostate cancer–specific mortality. Meanwhile, multiple management strategies exist, including surgery, radiation therapy, and active surveillance, which provide similar disease outcomes in appropriately selected men. As a result, treatment decisions for localized disease must account for not only oncologic outcomes but also preservation of urinary, bowel, and sexual function. Over the past several decades, advances in imaging, risk stratification (including genomics), and treatment delivery have steadily reshaped prostate cancer care with a common goal: in men with early-stage disease who receive local therapy, clinicians and investigators must attempt to optimize the therapeutic ratio by maintaining high rates of cancer control, while minimizing treatment-related morbidity.
https://jamanetwork.com/journals/jama/fullarticle/2852853
Prostate cancer has long served as a fertile ground for innovation in cancer therapy. Compared with many other malignancies, localized prostate cancer occupies a unique clinical space. Although the incidence of new diagnoses is high, prostate cancer often follows an indolent natural history, resulting in a low risk of prostate cancer–specific mortality. Meanwhile, multiple management strategies exist, including surgery, radiation therapy, and active surveillance, which provide similar disease outcomes in appropriately selected men. As a result, treatment decisions for localized disease must account for not only oncologic outcomes but also preservation of urinary, bowel, and sexual function. Over the past several decades, advances in imaging, risk stratification (including genomics), and treatment delivery have steadily reshaped prostate cancer care with a common goal: in men with early-stage disease who receive local therapy, clinicians and investigators must attempt to optimize the therapeutic ratio by maintaining high rates of cancer control, while minimizing treatment-related morbidity.
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Active Surveillance and Focal Therapy
https://jamanetwork.com/journals/jama/fullarticle/2852852
Hans Christian Andersen’s “The Emperor’s New Clothes” endures because an entire court learned to praise what it could not see. The fable warns that when prestige, novelty, and social pressure line up together, the absence of evidence can be mistaken for evidence of excellence. In the end, it took a child, untouched by those pressures, to say plainly that the emperor was in fact naked. Prostate cancer care is unfortunately highly vulnerable to the same error. Key opinion leaders, professional societies, reimbursement incentives, and market competition all influence clinicians, and new technologies arrive from industry dressed in the language of precision, personalization, and reduced morbidity. Two studies in this issue of JAMA ask that care be judged by its evidence rather than its appearance.
https://jamanetwork.com/journals/jama/fullarticle/2852852
Hans Christian Andersen’s “The Emperor’s New Clothes” endures because an entire court learned to praise what it could not see. The fable warns that when prestige, novelty, and social pressure line up together, the absence of evidence can be mistaken for evidence of excellence. In the end, it took a child, untouched by those pressures, to say plainly that the emperor was in fact naked. Prostate cancer care is unfortunately highly vulnerable to the same error. Key opinion leaders, professional societies, reimbursement incentives, and market competition all influence clinicians, and new technologies arrive from industry dressed in the language of precision, personalization, and reduced morbidity. Two studies in this issue of JAMA ask that care be judged by its evidence rather than its appearance.
Chemistry in America, 1876-1926
https://jamanetwork.com/journals/jama/fullarticle/2852851
This week the American Chemical Society celebrates its golden jubilee, with the presence at its session in Philadelphia of renowned chemists from all the chemical centers of the world. From a membership of 230 in 1876, the society has grown to 15,000—the largest chemical society in the world and the third largest scientific organization in America, the American Medical Association being first.
https://jamanetwork.com/journals/jama/fullarticle/2852851
This week the American Chemical Society celebrates its golden jubilee, with the presence at its session in Philadelphia of renowned chemists from all the chemical centers of the world. From a membership of 230 in 1876, the society has grown to 15,000—the largest chemical society in the world and the third largest scientific organization in America, the American Medical Association being first.
Focal Therapy for Prostate Cancer
https://jamanetwork.com/journals/jama/fullarticle/2852850
This retrospective study uses data from the National Cancer Database to examine patterns and temporal trends in use of focal therapy for prostate cancer in US cancer centers; characterize inappropriate use in low-, high-, or very–high-risk disease; and describe intermediate-risk use.
https://jamanetwork.com/journals/jama/fullarticle/2852850
This retrospective study uses data from the National Cancer Database to examine patterns and temporal trends in use of focal therapy for prostate cancer in US cancer centers; characterize inappropriate use in low-, high-, or very–high-risk disease; and describe intermediate-risk use.
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