Chédiak-Higashi Syndrome:
🔹Autosomal recessive
🔹Microtubules polymerization defect (impaired fusion of lysosomes and phagosomes)

Symptoms:
🔸Neutropenia
🔸Recurrent pyogenic infections
🔸Partial albinism
🔸Peripheral neuropathy

Factors that make SLE active:

✔️UV (sunshine)
✔️Pregnancy
✔️Infection
✔️Stress

Schizophrenia negative features
"4 A's":

🔶Ambivalence
🔶Affective incongruence
🔶Associative loosening
🔶Autism

Tuberous sclerosis presenting features:

✨Zits, Fits, Deficits✨

🔴Zits: adenoma sebaceum
🔴Fits: seizures
🔴Deficits: neurological deficits

☠Large cell lung cancer🚬:

🔘High beta-hCG
🔘Gynacomastia

💢Coronary Angiography💢
Gold standard for localizing and quantifying CAD

Differential Diagnosis of Poor Bilateral Breath Sounds after Intubation
🔅DOPE🔅
🔺Displaced ETT
🔺Obstruction
🔺Pneumothorax
🔺Esophageal intubation

Antistreptolysin titer (ASO) Used to help in Dx of:
⭕Bacterial endocarditis
⭕Post strep GN
⭕Rheumatic fever
⭕Scarlet fever
⭕Strep pharyngitis

🔘Edge of Ulcer:

✨Punch out edge➡Nurological
✨Undermined ➡Infection
✨Rolled ➡Basal cell carcinoma
✨Everted➡Sequamous cell carcinoma
✨Flat sloping➡Venous

Leukemia VS Aplastic Anemia:

✨ Leukemia:
▫Pancytopnia
▫Hepatosplenomegaly

✨Aplastic anaemia:
▫ Pancytopnia
▫ NO hepatosplenomegaly

4 Important Clinical Feature Of Carcinoid syndrome:

1🔷Wheezing
2🔷Diarrhoea
3🔷Flushing
4🔷Rt sided➡Valvular heart lesion

Asymmetrical Clubbing🔴Unilateral🔴:

🔹Anomalous aortic arch
🔹Aortic or subclavian artery aneurysm
🔹Brachial arteriovenous aneurysm

✨Clinical Triad of Hydatidiform Mole✨

❗️Uterine enlargement inconsistent with dates
❗️Hyperemesis gravidarum
❗️Markedly ⬆ hCG

🔺Endotracheal intubation “5 Ps indication🔺
💢Patent airway
💢Protects against aspiration
💢Positive pressure ventilation
💢Pulmonary toilet (suction)
💢Pharmacologic administration & hemodynamic instability

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