Answer: (C)
Statement 1 is correct: The Cleavable Light-Erased Antibody Reporter (CLEAR) technology is a highly multiplexed spatial protein imaging platform that allows a vast number of proteins to be visualized and mapped within the same cells or tissue sections by sequentially using just a single fluorescent marker (fluorophore).

Statement 2 is incorrect: CLEAR does not rely on harsh thermal or chemical stripping agents to remove fluorescent signals. Instead, it utilizes a gentle, non-destructive pulse of light to cleanly cleave a light-sensitive chemical linker, erasing the old signal without degrading the underlying tissue structure.

Statement 3 is correct: Because it avoids the aggressive and toxic chemical stripping methods utilized by older technologies, CLEAR's mild, light-driven erasing mechanism preserves delicate biological structures and is fully compatible with live-cell imaging.

Therefore, Option C is the correct answer.

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The National Investment and Infrastructure Fund (NIIF) mobilizes long-term domestic and global capital by partnering with sovereign wealth funds, pension funds, multilateral institutions, and other investors.

NIIF invests in key sectors such as transport, energy, digital infrastructure, logistics, urban infrastructure, and sustainable development.

Important for UPSC: Infrastructure financing, public-private investment, economic development, sovereign funds, and capital markets.

With reference to Tele-MANAS, consider the following statements:
1. It functions under the National Tele Mental Health Programme of the Ministry of Health and Family Welfare.
2. It aims to provide accessible mental health counselling and referral services, particularly for individuals unable to access in-person care.
3. It is implemented as a Centrally Sponsored Scheme.

Answer: (A)
Explanation
Tele-MANAS functions under the National Tele Mental Health Programme (NTMHP) of the Ministry of Health and Family Welfare. It was launched to strengthen access to quality mental healthcare services across the country. Hence, Statement 1 is correct.
Tele-MANAS provides 24×7 free tele-mental health counselling, screening and referral services, particularly benefiting individuals who are unable to access in-person mental healthcare due to geographical, financial or social barriers. Hence, Statement 2 is correct.
Tele-MANAS is not a Centrally Sponsored Scheme (CSS). It is an initiative under the National Tele Mental Health Programme (NTMHP) implemented by the Ministry of Health and Family Welfare. Hence, Statement 3 is incorrect.

Therefore, the correct answer is Option A (1 and 2 only).

With reference to the Logistics Ease Across Different States (LEADS) Report, consider the
following statements:
1. LEADS aims to improve logistics efficiency, reduce logistics costs and enhance ease of doing business.
2. LEADS 2025 assigned nearly 59% weightage to objective and measurable indicators.
3. Mizoram was recognised as the Exemplar State among the North-Eastern States in LEADS 2025.

Answer: (D)
● Statement 1 is Correct: The LEADS Report, released by Department for Promotion of Industry and Internal Trade (DPIIT), evaluates the logistics performance of States and Union Territories to strengthen India's logistics ecosystem by improving efficiency, reducing logistics costs and enhancing ease of doing business.
● Statement 2 – Correct: LEADS 2025 introduced a more rigorous and evidence-based assessment framework by assigning nearly 59% weightage to objective and measurable indicators. It also replaced the earlier three-tier classification with a four-tier categorisation system, enabling a more nuanced assessment of states at different stages of logistics development.
● Statement 3 – Correct: In LEADS 2025, Mizoram was recognised as the Exemplar State among the North-Eastern States for its logistics performance.

● Therefore, option D is the correct answer.

With reference to Laser Powder Bed Fusion (L-PBF), consider the following statements:
1. It is a 3D metal printing technology.
2. It is used to manufacture lightweight and high-strength aerospace components.
3. It can be used to produce customized medical implants.

Answer: (D)
L-PBF is a primary category of Metal Additive Manufacturing (3D printing). It uses a high-power laser to fuse fine metal powder particles layer-by-layer into solid, dense parts. Hence Statement 1 is correct.
In the aerospace industry, L-PBF is highly valued because it allows for topology optimization. This means engineers can remove material where it isn't needed, creating complex, lightweight internal lattice structures that maintain high strength, a crucial requirement for reducing aircraft fuel consumption. Hence Statement 2 is correct.
L-PBF is the gold standard for medical implants. Because the process is digital, a surgeon can take a patient's CT scan and create a custom-fit implant (such as a hip, knee, or cranial plate). Furthermore, L-PBF can print porous, "bone-like" surface textures that significantly improve osseointegration (the process where the patient's bone grows into the implant). Hence Statement 3 is correct.

Therefore , Option D is the correct answer.

Consider the following statements regarding Goods and Services Tax (GST) collections in
India:
1. Higher GST collections mainly indicate broad-based growth in domestic manufacturing and industrial value addition.
2. Growth in Integrated GST (IGST) collections can also be influenced by factors such as currency depreciation and higher global commodity prices, even without a significant increase in import volumes.
3. Weak performance of the eight core industries may indicate a slowdown in domestic economic activity despite higher GST collections.