[UZ] 📢 Navbatdagi maqolamiz Nature nashryotining Scientific Reports jurnalida chop etildi! 🎉
Saraton hujayralaridagi PD-L1 va PD-L2 immun nazorat oqsillari immun hujayralari faolligini boshqarishda muhim rol o‘ynaydi va immun retseptori PD1 oqsili bilan bog'lanishi saraton hujayralari tomonidan “himoya mexanizmi (don't eat me signal)” sifatida ishlatiladi. Tadqiqotimizda sovuq atmosferik plazma (SAP) tomonidan oksidlanish oqsillarni bog'lanishiga qanday ta’sir ko‘rsatishini molekulyar dinamika (MD) simulyatsiyalari yordamida o‘rgandik. Natijalarimiz SAP ta’sirida oksidlanish kuchayishi PD-1 va uning ligandlari (PD-L1/PD-L2) o‘rtasidagi bog‘lanishni zaiflashtirishini ko‘rsatdi. Bu esa saratonga qarshi immunitet hujayralarini faolligini kuchaytirishda yangi strategiya sifatida foydalanish mumkin.
Ushbu tadqiqotni iste’dodli magistrantlarim: Rasulbek Mashalov (Debretsen Universiteti) va Zulfizar Toshpulatova (O‘zbekiston Milliy Universiteti, Kimyo fakulteti) tomonidan amalga oshirilgan. 🙌 Shogirdlarimning muvaffaqiyatini ko‘rish men uchun beqiyos quvonch va faxrdir. 🌟
[EN] 📢 Our latest paper has been published in Scientific Reports, a journal from the Nature Publishing Group! 🎉
The immune checkpoint proteins PD-L1 and PD-L2 play a crucial role in regulating the activity of immune cells, and their binding with PD-1 is often exploited by cancer cells as a “don’t eat me” signal. In our study, we used molecular dynamics (MD) simulations to investigate how cold atmospheric plasma (CAP)-induced oxidation affects these protein interactions. Our findings show that increasing oxidation levels caused by CAP weaken the binding between PD-1 and its ligands (PD-L1/PD-L2). This suggests a promising new strategy to enhance the activity of immune cells against cancer.
This research was carried out thanks to the remarkable efforts of my talented Master’s students: Rasul Mashalov (University of Debrecen) and Zulfizar Toshpulatova (National University of Uzbekistan, Faculty of Chemistry). 🙌 Seeing the success of my students brings me immense joy and pride. 🌟 https://www.nature.com/articles/s41598-025-12902-x#additional-information
Saraton hujayralaridagi PD-L1 va PD-L2 immun nazorat oqsillari immun hujayralari faolligini boshqarishda muhim rol o‘ynaydi va immun retseptori PD1 oqsili bilan bog'lanishi saraton hujayralari tomonidan “himoya mexanizmi (don't eat me signal)” sifatida ishlatiladi. Tadqiqotimizda sovuq atmosferik plazma (SAP) tomonidan oksidlanish oqsillarni bog'lanishiga qanday ta’sir ko‘rsatishini molekulyar dinamika (MD) simulyatsiyalari yordamida o‘rgandik. Natijalarimiz SAP ta’sirida oksidlanish kuchayishi PD-1 va uning ligandlari (PD-L1/PD-L2) o‘rtasidagi bog‘lanishni zaiflashtirishini ko‘rsatdi. Bu esa saratonga qarshi immunitet hujayralarini faolligini kuchaytirishda yangi strategiya sifatida foydalanish mumkin.
Ushbu tadqiqotni iste’dodli magistrantlarim: Rasulbek Mashalov (Debretsen Universiteti) va Zulfizar Toshpulatova (O‘zbekiston Milliy Universiteti, Kimyo fakulteti) tomonidan amalga oshirilgan. 🙌 Shogirdlarimning muvaffaqiyatini ko‘rish men uchun beqiyos quvonch va faxrdir. 🌟
[EN] 📢 Our latest paper has been published in Scientific Reports, a journal from the Nature Publishing Group! 🎉
The immune checkpoint proteins PD-L1 and PD-L2 play a crucial role in regulating the activity of immune cells, and their binding with PD-1 is often exploited by cancer cells as a “don’t eat me” signal. In our study, we used molecular dynamics (MD) simulations to investigate how cold atmospheric plasma (CAP)-induced oxidation affects these protein interactions. Our findings show that increasing oxidation levels caused by CAP weaken the binding between PD-1 and its ligands (PD-L1/PD-L2). This suggests a promising new strategy to enhance the activity of immune cells against cancer.
This research was carried out thanks to the remarkable efforts of my talented Master’s students: Rasul Mashalov (University of Debrecen) and Zulfizar Toshpulatova (National University of Uzbekistan, Faculty of Chemistry). 🙌 Seeing the success of my students brings me immense joy and pride. 🌟 https://www.nature.com/articles/s41598-025-12902-x#additional-information
Nature
Molecular dynamics insights into the redox effects on PD-1/PD-L1 and PD-1/PD-L2 interactions
Scientific Reports - Molecular dynamics insights into the redox effects on PD-1/PD-L1 and PD-1/PD-L2 interactions
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⭐️ Exciting News! ⭐️
The Plasma Modelling Online Symposium – Methods and Applications!
Attend lectures from Ivan Tsonev and many more plasma modelling specialists!
🗓 Monday, November 17, 9:00 - 17:30 (online)
👉 Register now: https://lnkd.in/d2-cizR2
The Plasma Modelling Online Symposium – Methods and Applications!
Attend lectures from Ivan Tsonev and many more plasma modelling specialists!
🗓 Monday, November 17, 9:00 - 17:30 (online)
👉 Register now: https://lnkd.in/d2-cizR2
lnkd.in
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📍 Respublika shoshilinch tibbiy yordam ilmiy markazi ilmiy ishlar boʻyicha direktor oʻrinbosari, tibbiyot fanlari doktori Shuhrat Otajonov shogirdi bilan institutimizga tashrif buyurdilar. 👨⚕️🤝
🏥 Shifoxonalarda duch kelinadigan eng katta muammolardan biri — bakteriyalarning antibiotiklarga qarshilik (rezistentlik) darajasi juda yuqori bo‘lishidir. Ular doimiy antibiotik qo‘llanilishi oqibatida mutatsiyaga uchraydi va shifoxonadagi infeksiyalar xavfini oshiradi.
💡 Tashrif davomida shifoxonadagi infeksiyalarga qarshi plazma texnologiyasini qo‘llash bo‘yicha hamkorlik taklifi bildirildi. Ilmiy guruhimiz hozirda plazmani tibbiyot amaliyotida qo‘llash ustida faol tadqiqotlar olib bormoqda.
⚡️ Hamkorlarimiz tomonidan ishlab chiqilgan kichik energiyali plazma reaktori bizga sinov uchun taqdim etilgan bo‘lib, uni endilikda shifoxonadagi in-vitro va in-vivo tajribalarda qo‘llash rejalashtirilmoqda.
🔬 Adabiyotlarda ko‘rsatilishicha, plazma hosil qilgan reaktiv kislorod va azot zarralari (RONS) turli infeksiyalarni samarali yo‘q qiladi. Bizning natijalarimiz qanday bo‘ladi?
Ijobiy natijalarni kutmoqdamiz! 💪✨
🏥 Shifoxonalarda duch kelinadigan eng katta muammolardan biri — bakteriyalarning antibiotiklarga qarshilik (rezistentlik) darajasi juda yuqori bo‘lishidir. Ular doimiy antibiotik qo‘llanilishi oqibatida mutatsiyaga uchraydi va shifoxonadagi infeksiyalar xavfini oshiradi.
💡 Tashrif davomida shifoxonadagi infeksiyalarga qarshi plazma texnologiyasini qo‘llash bo‘yicha hamkorlik taklifi bildirildi. Ilmiy guruhimiz hozirda plazmani tibbiyot amaliyotida qo‘llash ustida faol tadqiqotlar olib bormoqda.
⚡️ Hamkorlarimiz tomonidan ishlab chiqilgan kichik energiyali plazma reaktori bizga sinov uchun taqdim etilgan bo‘lib, uni endilikda shifoxonadagi in-vitro va in-vivo tajribalarda qo‘llash rejalashtirilmoqda.
🔬 Adabiyotlarda ko‘rsatilishicha, plazma hosil qilgan reaktiv kislorod va azot zarralari (RONS) turli infeksiyalarni samarali yo‘q qiladi. Bizning natijalarimiz qanday bo‘ladi?
Ijobiy natijalarni kutmoqdamiz! 💪✨
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Forwarded from Jamoliddin Razzokov
Source: ScienceDaily
https://search.app/xrKJW
https://search.app/xrKJW
ScienceDaily
Scientists grow metal instead of 3D printing it — and it’s 20x stronger
Scientists at EPFL have reimagined 3D printing by turning simple hydrogels into tough metals and ceramics. Their process allows multiple infusions of metal salts that form dense, high-strength structures without the porosity of earlier methods. Early results…
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🌐 ICPSA 2025 — 3 kunlik konferensiya muvaffaqiyatli yakunlandi
Empark Grand Hotel mezbonligida bo‘lib o‘tgan ICPSA 2025 konferensiyasi uch kun davomida yuqori saviyada tashkil etildi.
🗓 1-kun — asosan plenar ma’ruzalar bilan boshlandi, yetakchi olimlarning taqdimotlari tinglandi.
🗓 2-kun — taklif etilgan ma’ruzachilar va poster taqdimotlar parallel sessiyalar bilan davom etdi.
🗓 3-kun — Elektr muhandisligi maktabi laboratoriyasiga ilmiy tashrif, zamonaviy plazma tadqiqot infratuzilmalari bilan yaqindan tanishdik.
Konferensiya davomida juda muhim ilmiy fikrlar va yangi g‘oyalarni oldim. Hamkorlar bilan olib borayotgan loyihamiz bo‘yicha yana bir bor samarali suhbatlar o‘tkazdik.
🤝 Eng muhim yangilik — biz institutimiz va Xi’an Jiaotong Universitetidagi Plazma Biotibbiyot Markazi (Prof. Dingxin Liu) o‘rtasida qo‘shma laboratoriya tashkil etish bo‘yicha Memorandum (MoU) tayyorladik. Ushbu hujjat universitet rahbariyati tomonidan tasdiqlangach, rasman imzolanadi. Bu kelajakdagi hamkorlik uchun katta qadam bo'ldi.
Samimiy taklif uchun Prof. Renwu Zhou va Prof. Dingxin Liuga chuqur minnatdorlik bildiraman.
Empark Grand Hotel mezbonligida bo‘lib o‘tgan ICPSA 2025 konferensiyasi uch kun davomida yuqori saviyada tashkil etildi.
🗓 1-kun — asosan plenar ma’ruzalar bilan boshlandi, yetakchi olimlarning taqdimotlari tinglandi.
🗓 2-kun — taklif etilgan ma’ruzachilar va poster taqdimotlar parallel sessiyalar bilan davom etdi.
🗓 3-kun — Elektr muhandisligi maktabi laboratoriyasiga ilmiy tashrif, zamonaviy plazma tadqiqot infratuzilmalari bilan yaqindan tanishdik.
Konferensiya davomida juda muhim ilmiy fikrlar va yangi g‘oyalarni oldim. Hamkorlar bilan olib borayotgan loyihamiz bo‘yicha yana bir bor samarali suhbatlar o‘tkazdik.
🤝 Eng muhim yangilik — biz institutimiz va Xi’an Jiaotong Universitetidagi Plazma Biotibbiyot Markazi (Prof. Dingxin Liu) o‘rtasida qo‘shma laboratoriya tashkil etish bo‘yicha Memorandum (MoU) tayyorladik. Ushbu hujjat universitet rahbariyati tomonidan tasdiqlangach, rasman imzolanadi. Bu kelajakdagi hamkorlik uchun katta qadam bo'ldi.
Samimiy taklif uchun Prof. Renwu Zhou va Prof. Dingxin Liuga chuqur minnatdorlik bildiraman.
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