Life: The area changes turning into a golden background with DNA-like shapes in the background. A Flower of Life appears on the ground and the gimmick requires you to destroy it. After destroying it, you need to defeat all "Creatures of Life" at the same time within the time limit to shatter the Flower of Life's shield.
Death: The area changes turning into a red and black background similar to Ronova's fight. It impales your character while applying something like the Torrent of Death on your characters, you need to defend the target simil-Gnosis against Death-enemies within the time limit.
Time: The area changes turning into a blue and purple background full of golden threads. A Sands of Eon appears on the ground and you need to use Cryo to freeze the Time Particles and Anemo to destroy and interrupt a charging advancement.
Space: The area becomes similar to the Apathic Interval of the Temple of Space, grey background with Asmoday Portals on the sky. Your screen turns into a minigame similar to Bullet Hell, you need to complete it (very easy).
After dealing with this, Metatron has few HP and you'll defeat it.