(Ref: Robbins 8/e p29-30, 9/e p56)
In the activation of Extrinsic pathway of apoptosis, binding of Fas ligand takes place to CD95 (Fas; member of TNF receptor
family) or binding of TRAIL (TNF related apoptosis inducing ligand) attaches to death receptors DR4 and DR5. This induces
the association of FADD (Fas- associated death domain) and procaspase-8 to death domain motifs of the receptors resulting in
activation of caspase 8 (in humans caspase 10) which finally activates caspases- 3 and 7 that are final effector caspases

#DVTupdate

Hello doctors
We have updated the content of softcopy till day 5 on NND application. You can read the content till your Hardcopy delivers.
Softcopy content will no longer be free for any user except Hardcopy and softcopy buyer's.
If anyone from hardcopy/softcopy buyer's Hasn't subscribed to the product, we'll automatically assign from backend by EOD.

Regards
Team NND ❤️

#Dvtupdate

Since we got 65% vote from 2nd and 3rd slot buyer's or buyers who booked hardcopy on/after 22nd October that they wanted us to dispatch their vol 1 early.

Charges would be just 100rs

Click the link :
https://rzp.io/l/O78Lpi9DW

Note :
1. vol 1 will be dispatched on 2nd November 2020 since on 1st it's Sunday.
2. Notes will be shipped via the fastest medium possible on the pincode specified.
3. No query for Address change will be entertained.
4. NND will not be responsible if the number you specified is not reachable/switched off/ not picked/ busy and the courier returns back.
5. If a courier returns back,buyer will be liable to pay the courier charges again to ship it back.
6. It's optional not mandatory. If you want it to be dispatched early only then pay.

Regards
Team NND ❤️

#Dvtupdate

Second and Third slots will be shipped from 6th November onwards.
Note: This is a tentative date. This date might change depending on the conditions.

Regards
Team NND ❤️
@notesnextdoor

Ans. C. The surgeon must use the single-layer, extra mucosal suture technique
• The standard technique used currently for resection anastomosis of the bowel is a one-layer extra mucosal suture technique, since it causes the least tissue necrosis and luminal narrowing.
• Interrupted and continuous single-layer suture techniques are adequate and safe.
• The extra mucosal suture must also include the submucosa, because this layer has a high collagen content and it is the most stable suture layer in all sections of the gastrointestinal (GI) tract.
• Regarding the suture material, catgut has now been replaced with absorbable synthetic polymers. Stapling devices can be used when speed is required.

#Dvtupdate

Hello doctor's
Slot 1 has been successfully dispatched .
Tracking ids will be updated within 24 hrs.

Regards
Team NND ❤️

EXPLANATION:
Inflammation involving an epithelial surface may
cause such extensive necrosis that the surface becomes
eroded, forming an ulcer. If the inflammation continues,
the ulecer can continue to penetrate downward into submu-
cosa and muscularis. Alternatively, the ulcer may heal, or it
may remain chronically inflamed. An abscess is a localized
collection of neutrophils in tissues. A caseating granuloma
is granulomatous inflammation with central necrosis; the
necrosis has elements of both liquefaction and coagula-
tive necrosis. Chronic inflammation occurs when there is
a preponderance of mononuclear cells, such as lympho-
cytes, macrophages, and plasma cells, in a process that has
gone on for more than a few days—more likely weeks or
months—or that accompanies repeated bouts of acute in-
flammation. Pus, or a purulent exudate, appears semiliquid
and yellowish because of the large numbers of granulocytes
present. A serous effusion is a watery-appearing transudate
that resembles an ultrafiltrate of blood plasma, with a low
cell and protein content

#Dvtupdate

Hello Doctors
Most of the tracking ids have been updated successfully. Kindly kill your app and check your order section. We are still updating tracking ids, those who have not received the dispatch notification with tracking id will receive soon within 24 hrs.

All students from slot 1 will receive DVT notes in 2 packets .
This is done to avoid damage to the notes .
If you receive one packet early don't panic you will receive other one too.

#softcopyupdate
Rest softcopies will be updated within 24 hrs.
We are updating in parts because the files are very heavy and if we upload whole file at once it would be very difficult for most of the students to open since it will take alot of time.

Regards
Team NND ❤️

EXPLANATION:
Single nucleotide polymorphisms (SNPs) are found
in less than 0.5% of the genome, and only 1% of these are
found in coding regions that affect protein synthesis. Some
of these account for point mutations that may be associated
with disease conditions. C number variations (CNVs) in-
volve variations in large contiguous regions of DNA from
1000 to a million base pairs. Epigenetic changes involve
modulation of gene expression without any change in the
DNA. Trinucleotide repeats involve increased numbers of
base pairs. RNA alterations may modulate DNA expres-
sion, such as noncoding micro RNAs.