Serine starvation induces stress and p53-dependent metabolic remodelling in cancer cells

"Here we show that human cancer cells rapidly use exogenous serine and that serine deprivation triggered activation of the serine synthesis pathway and rapidly suppressed aerobic glycolysis, resulting in an increased flux to the tricarboxylic acid cycle. Transient p53-p21 (also known as CDKN1A) activation and cell-cycle arrest promoted cell survival by efficiently channelling depleted serine stores to glutathione synthesis, thus preserving cellular anti-oxidant capacity. Cells lacking p53 failed to complete the response to serine depletion, resulting in oxidative stress, reduced viability and severely impaired proliferation. The role of p53 in supporting cancer cell proliferation under serine starvation was translated to an in vivo model, indicating that serine depletion has a potential role in the treatment of p53-deficient tumours."

[Posted by @RobinMG]

https://www.nature.com/articles/nature11743?s=09

Asparagine bioavailability governs metastasis in a model of breast cancer

"Here we show that asparagine bioavailability strongly influences metastatic potential. Limiting asparagine by knockdown of asparagine synthetase, treatment with L-asparaginase, or dietary asparagine restriction reduces metastasis without affecting growth of the primary tumour, whereas increased dietary asparagine or enforced asparagine synthetase expression promotes metastatic progression. Altering asparagine availability in vitro strongly influences invasive potential, which is correlated with an effect on proteins that promote the epithelial-to-mesenchymal transition. This provides at least one potential mechanism for how the bioavailability of a single amino acid could regulate metastatic progression."

[Posted by @RobinMG]

https://www.nature.com/articles/nature25465?s=09

Use of the Anti-Parasitic Drug Ivermectin to Treat Breast Cancer

"In these studies, 40-60 percent of animals treated with the ivermectin plus anti-PD1 antibody combination completely eradicated their tumors. They were able to fight off the cancer again after it was reintroduced. It's the two drugs working together that is the magic. Either drug alone has almost zero effect, but together they have a powerful synergistic effect.

Our team then tested the combination across a spectrum of clinically relevant settings. We found that the therapeutic combination also worked in neoadjuvant models (before surgery) and adjuvant models (after surgery). Most importantly, the combination worked against metastatic breast cancer, potentially curing 50 percent of animals.
Based on its novel dual mechanisms of action (anti-cancer and immunomodulatory) in cancer, ivermectin may also potentiate the anti-tumor activity of other FDA-approved ICIs. Ivermectin is safe and inexpensive at roughly $30 a dose, making it attainable for everyone including cancer patients in developing countries.

These preclinical findings suggest that the combination of ivermectin and anti-PD1 antibody merits clinical testing in breast cancer patients. We are now planning to test optimal dosing levels for a potential first-in-human clinical trial. Interestingly, in the last year, ivermectin has also demonstrated efficacy against COVID-19, and it is being tested in dozens of clinical trials to both prevent and treat the virus."

[Posted by @RobinMG]

https://journals.lww.com/oncology-times/fulltext/2021/05050/use_of_the_anti_parasitic_drug_ivermectin_to_treat.4.aspx?s=09

▶️ Donbas civilians say 'no' to more NATO weapons

@johnnyjamesmiller reports from Donbas.

#UkraineWar

@PressTV

Feb 12, 2023:

Kevork Almassian was hosted by the Chinese CGTN to report on the latest earthquake updates in Syria.

https://www.youtube.com/watch?v=W13BYXvQGFM

September 10, 2012

"The Ivy League bourgeoisie who sit at the helm of the non-profit industrial complex will one day be known simply as charismatic architects of death. Funded by the ruling class oligarchy, the role they serve for their funders is not unlike that of corporate media. Yet, it appears that global society is paralyzed in a collective hypnosis – rejecting universal social interests, thus rejecting reason, to instead fall in line with the position of the powerful minority that has seized control, a minority that systematically favours corporate interests.

This investigative report examines the key founders of Avaaz, as well as other key sister organizations affiliated with Avaaz who, hand in hand with the Rockefellers, George Soros, Bill Gates and other powerful elites, are meticulously shaping global society by utilizing and building upon strategic psychological marketing, soft power, technology and social media – shaping public consensus, thus acceptance, for the illusory “green economy” and a novel sonata of 21st century colonialism. As we are now living in a world that is beyond dangerous, society must be aware of, be able to critically analyze, and ultimately reject the new onslaught of carefully orchestrated depoliticization, domestication of populace, propaganda and misinformation that is being perpetrated and perpetuated by the corporate elite and the current power structures that support their agenda. The non-profit industrial complex must be understood as a mainspring and the instrument of power, the very support and foundation of imperial domination."

https://www.wrongkindofgreen.org/2012/09/10/avaaz-imperialist-pimps-of-militarism-protectors-of-the-oligarchy-trusted-facilitators-of-war/

The COVID pLandemic and lockstep response to it is the biggest fraud in Medical history, arguably unfolding into the worst crime against humanity, all predicated on LIES.

TWENTY MILLION LIES
Odysee video 7Minutes
https://odysee.com/@FreedomTirade:f/20-MILLION-LIES:4?r=

"Normal" People will be enraged if they ever realise the true extent to which relevant heads of healthcare have been lying in sync with political leaders and evil corporations about the situation that they themselves created , for their own profit and control over us.

We honour:
UK MP Andrew Bridgen for having had the courage to speak out in this time of universal deceit in the worst miscarriage of medical science via the deadliest mass formation of ignorance ever.

We Diss:
Fauci and Osterholm. Two US deep state fear porn pushing, gene-jab shilling gangsta merchants.

Disclaimer:
@freedomtirade montages are intended to incite medical revolution by piercing the lies of brutal charlatan eugenicists who have hijacked medical science.

"every single part of
the COVID narrative,
EVERY SINGLE PART IS A LIE"
Dr.Mike Yeadon.

REVOLVING DOORS of Davos have allowed the world to be conned by medical malfeasance, corruption and miscarriage of medical science during COVID and still to this day.

"This is the worst ever miscarriage of medical science"
Dr Aseem Malhotra

"Truth.. is like kryptonite and nothing can stop it now."
- Dr.Peter McCullough

Big UP to the Rebel News crew for their ambush of deep state pFizer patsy/agent Bourla at WEF Davos 2023.

Hats off to South Africa for leading a charge for freedom once again. AMANDLA.

REVOLVING DOORS on Odysee 11minutes:
https://odysee.com/@FreedomTirade:f/REVOLVING-DOORS:e

Pursue HEALTH:
practice optimum nutrition,
physical fluidity
and love.
Resist TYRANNY:
download-copy-upload-share

Disclaimer:
@freedomtirade montages are fully intended to spark a medical revolution towards true health and the ending of tyranny.

Bill Gates says:
To restore trust in Science we need to slow down the crazy stuff
(conspiracy 'theories')

We say:
To restore trust in Science we need the Whole GATES GANG behind bars.

SLOW DOWN THE CRAZY STUFF
montage 8minutes:
https://odysee.com/@FreedomTirade:f/crazy-stuff:e1

GATES GANG Conspirators and infiltrators :
• WEF and associated politicians
• Gates Foundation
• CEPI - founded by Gates
• WHO
• Wellcome Trust
• Rockefeller Foundation
• CCP
• GAVI
• Eco Health Alliance
• CDC, NIH, FDA, regulatory agencies across the world
• Vaccine manufacturers
• Corporate media & big tech
• Hospital systems

Pursue HEALTH:
practice optimum nutrition,
physical fluidity
and love.
Resist TYRANNY:
download-copy-upload-share

More here:
https://t.me/TheWellnessCompany/133


Disclaimer: @freedomtirade montages may incite medical revolution to arrest and prosecute the Gates Gang of corrupt medical charlatans who played a hand in the COVID scams, censoring of truth and persecution of honest, ethical doctors.

"If I'd wanted to live in ‘the "safest" place in the world to be online,’ I’d have moved to China” - Lord Moylan skewers Online Safety Bill

#OnlineSafetyBill is a massive attack on free expression - and never in a million years ‘safe’