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https://blog.it-kb.ru/2016/02/18/installing-update-kb3102467-net-framework-4-6-1-on-windows-server-2012-r2-can-cause-problems-with-exchange-lync-skype-for-business-sharepoint-servers-rd-gateway-and-other-software/
Внимание, грабли. Обновление KB3102467 - .NET Framework 4.6.1