Brokers, the State Health Insurance Assistance Program, and Medicare Insurance
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2848656
Health Care Policy
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2848656
Health Care Policy
HIV Testing and Diagnosis Among Hispanic or Latino Adults
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2848655
This cohort study assesses HIV testing, test positivity, and cultural and personal factors associated with these outcomes among adults of Hispanic or Latino ethnicity in the US.
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2848655
This cohort study assesses HIV testing, test positivity, and cultural and personal factors associated with these outcomes among adults of Hispanic or Latino ethnicity in the US.
Scalability of Chat-Based Cessation
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2848653
To the Editor We read with great interest the randomized clinical trial by Luk and colleagues, which demonstrated that a mobile chat messaging intervention significantly reduced smoking relapse. The finding that a hybrid model combining live counseling and chatbot support increased 6-month validated abstinence is a pivotal contribution. However, as we consider scaling this approach, 2 critical dimensions regarding the “active ingredients” and workforce sustainability warrant further scrutiny.
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2848653
To the Editor We read with great interest the randomized clinical trial by Luk and colleagues, which demonstrated that a mobile chat messaging intervention significantly reduced smoking relapse. The finding that a hybrid model combining live counseling and chatbot support increased 6-month validated abstinence is a pivotal contribution. However, as we consider scaling this approach, 2 critical dimensions regarding the “active ingredients” and workforce sustainability warrant further scrutiny.
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Error in Abstract
https://jamanetwork.com/journals/jama/fullarticle/2849317
In the Original Investigation titled “National Estimates of Pediatric Sepsis in US Hospitals Using Clinical Data,” published in the April 21, 2026, issue of JAMA, a typo occurred in the Abstract. In the Results section, the first sentence should have stated “3 926 809 pediatric hospitalizations.” This article was corrected online.
https://jamanetwork.com/journals/jama/fullarticle/2849317
In the Original Investigation titled “National Estimates of Pediatric Sepsis in US Hospitals Using Clinical Data,” published in the April 21, 2026, issue of JAMA, a typo occurred in the Abstract. In the Results section, the first sentence should have stated “3 926 809 pediatric hospitalizations.” This article was corrected online.
340B Drug Pricing
https://jamanetwork.com/journals/jama/fullarticle/2849130
This Viewpoint presents the history of the Health Resources & Services Administration (HRSA) 340B Drug Pricing Program and 340B Rebate Model Pilot Program, summarizes their controversies and limitations, and calls for action by Congress and HRSA to address these issues and strengthen support for safety-net hospitals and clinics.
https://jamanetwork.com/journals/jama/fullarticle/2849130
This Viewpoint presents the history of the Health Resources & Services Administration (HRSA) 340B Drug Pricing Program and 340B Rebate Model Pilot Program, summarizes their controversies and limitations, and calls for action by Congress and HRSA to address these issues and strengthen support for safety-net hospitals and clinics.
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Advancing Pharmacoequity in Asthma
https://jamanetwork.com/journals/jama/fullarticle/2849316
A remarkable aspect of modern medicine is the ever-growing array of medications that fundamentally alter disease trajectories and improve quality of life. At the same time, persistent inequities in access to these medications remain a reality. Pharmacoequity, a term coined in a 2021 article in JAMA, is a specific component of health equity focused on fair and just access to appropriate medications, regardless of race, ethnicity, income, insurance coverage, and other social factors.
https://jamanetwork.com/journals/jama/fullarticle/2849316
A remarkable aspect of modern medicine is the ever-growing array of medications that fundamentally alter disease trajectories and improve quality of life. At the same time, persistent inequities in access to these medications remain a reality. Pharmacoequity, a term coined in a 2021 article in JAMA, is a specific component of health equity focused on fair and just access to appropriate medications, regardless of race, ethnicity, income, insurance coverage, and other social factors.
Disparities in Inhaler Utilization Among US Adults With Asthma
https://jamanetwork.com/journals/jama/fullarticle/2849315
This cross-sectional cohort study examines inhaler use among US adults with asthma and how demographic, socioeconomic, clinical, and heath care access factors may affect treatment disparities in this population.
https://jamanetwork.com/journals/jama/fullarticle/2849315
This cross-sectional cohort study examines inhaler use among US adults with asthma and how demographic, socioeconomic, clinical, and heath care access factors may affect treatment disparities in this population.
Cryobiopsy vs Forceps for Bronchoscopic Lung Biopsy
https://jamanetwork.com/journals/jama/fullarticle/2849314
This trial investigates the diagnostic yield of transbronchial lung biopsy with a 1.1-mm cryoprobe vs 2.0-mm forceps.
https://jamanetwork.com/journals/jama/fullarticle/2849314
This trial investigates the diagnostic yield of transbronchial lung biopsy with a 1.1-mm cryoprobe vs 2.0-mm forceps.
Structural Assumptions in Semaglutide Cost-Effectiveness
https://jamanetwork.com/journals/jamacardiology/fullarticle/2849152
To the Editor Hennessy and colleagues present a rigorous and timely cost-effectiveness analysis of semaglutide for secondary prevention of cardiovascular disease (CVD) in adults with overweight or obesity without diabetes. Application of the validated CVD Policy Model projects significant reductions in major adverse cardiovascular events and demonstrates that value estimates are highly sensitive to drug pricing.
https://jamanetwork.com/journals/jamacardiology/fullarticle/2849152
To the Editor Hennessy and colleagues present a rigorous and timely cost-effectiveness analysis of semaglutide for secondary prevention of cardiovascular disease (CVD) in adults with overweight or obesity without diabetes. Application of the validated CVD Policy Model projects significant reductions in major adverse cardiovascular events and demonstrates that value estimates are highly sensitive to drug pricing.
Structural Assumptions in Semaglutide Cost-Effectiveness—Reply
https://jamanetwork.com/journals/jamacardiology/fullarticle/2849151
In Reply We thank Zavaleta-Monestel and Arguedas-Chacon for their thoughtful comments on our cost-effectiveness analysis of semaglutide for secondary prevention of cardiovascular disease. We agree that sensitivity analyses examining the impact of parameter or structural uncertainty are extremely informative, especially as they relate to long-term effectiveness and safety of novel therapies.
https://jamanetwork.com/journals/jamacardiology/fullarticle/2849151
In Reply We thank Zavaleta-Monestel and Arguedas-Chacon for their thoughtful comments on our cost-effectiveness analysis of semaglutide for secondary prevention of cardiovascular disease. We agree that sensitivity analyses examining the impact of parameter or structural uncertainty are extremely informative, especially as they relate to long-term effectiveness and safety of novel therapies.
Resuscitation Quality Improvement Training and Cardiac Arrest Survival in Hospitals
https://jamanetwork.com/journals/jamacardiology/fullarticle/2849150
This cohort study examines whether the adoption of the Resuscitation Quality Improvement program for quarterly cardiopulmonary resuscitation training in US hospitals is associated with improved survival outcomes in in-hospital cardiac arrest.
https://jamanetwork.com/journals/jamacardiology/fullarticle/2849150
This cohort study examines whether the adoption of the Resuscitation Quality Improvement program for quarterly cardiopulmonary resuscitation training in US hospitals is associated with improved survival outcomes in in-hospital cardiac arrest.
Weight Loss for Atrial Fibrillation Prevention
https://jamanetwork.com/journals/jama/fullarticle/2849341
Atrial fibrillation, the most common sustained arrhythmia encountered in clinical practice, is now considered a preventable disorder. Professional societies and the National Institutes of Health have highlighted the importance of addressing lifestyle factors as a pillar in the management of atrial fibrillation. Central among these is weight loss in individuals with overweight (body mass index [BMI, calculated as weight in kilograms divided by height in meters squared] between ≥27 and <30) and obesity (BMI ≥30), which now garners a class 1 recommendation in both US and European guidelines to reduce the risk of atrial fibrillation. The evidence supporting those recommendations is extensive.
https://jamanetwork.com/journals/jama/fullarticle/2849341
Atrial fibrillation, the most common sustained arrhythmia encountered in clinical practice, is now considered a preventable disorder. Professional societies and the National Institutes of Health have highlighted the importance of addressing lifestyle factors as a pillar in the management of atrial fibrillation. Central among these is weight loss in individuals with overweight (body mass index [BMI, calculated as weight in kilograms divided by height in meters squared] between ≥27 and <30) and obesity (BMI ≥30), which now garners a class 1 recommendation in both US and European guidelines to reduce the risk of atrial fibrillation. The evidence supporting those recommendations is extensive.
Hantavirus Outbreak Tests US After WHO Withdrawal
https://jamanetwork.com/journals/jama/fullarticle/2849537
This Medical News article discusses ongoing developments in the hantavirus cruise ship outbreak and the effect of the withdrawal of the US from the World Health Organization on managing the outbreak.
https://jamanetwork.com/journals/jama/fullarticle/2849537
This Medical News article discusses ongoing developments in the hantavirus cruise ship outbreak and the effect of the withdrawal of the US from the World Health Organization on managing the outbreak.
The Obesity Epidemic at a Crossroads—Progress and Pitfalls
https://jamanetwork.com/journals/jama/fullarticle/2849330
This Viewpoint discusses opportunities for policymakers and practitioners to make progress in the public health challenge of obesity while avoiding unintended consequences.
https://jamanetwork.com/journals/jama/fullarticle/2849330
This Viewpoint discusses opportunities for policymakers and practitioners to make progress in the public health challenge of obesity while avoiding unintended consequences.
Primary Care as a Public Utility
https://jamanetwork.com/journals/jama/fullarticle/2849331
This Special Communication explores the challenges currently facing state investment in primary care and outlines how a common fund could address these challenges and sustain primary care as a public utility and common good.
https://jamanetwork.com/journals/jama/fullarticle/2849331
This Special Communication explores the challenges currently facing state investment in primary care and outlines how a common fund could address these challenges and sustain primary care as a public utility and common good.
Lifestyle Modification and Incretin-Based Therapy for Obesity
https://jamanetwork.com/journals/jama/fullarticle/2849340
This JAMA Insights discusses strategies for lifestyle modifications and managing adverse effects for individuals with obesity receiving incretin-based therapies for weight loss.
https://jamanetwork.com/journals/jama/fullarticle/2849340
This JAMA Insights discusses strategies for lifestyle modifications and managing adverse effects for individuals with obesity receiving incretin-based therapies for weight loss.
Acetaminophen (Paracetamol) or Opioid Plus Ibuprofen for Children’s Musculoskeletal Injury
https://jamanetwork.com/journals/jama/fullarticle/2849339
To the Editor Dr Ali and colleagues reported no additional analgesic benefit from adding acetaminophen (paracetamol) or hydromorphone to ibuprofen for children with acute musculoskeletal injuries. In all groups, the ibuprofen dose was 10 mg/kg and the acetaminophen dose was 15 mg/kg, with pain assessed 60 minutes after drug administration. Pain scores did not differ between ibuprofen monotherapy and either combination (ibuprofen plus acetaminophen or ibuprofen plus hydromorphone).
https://jamanetwork.com/journals/jama/fullarticle/2849339
To the Editor Dr Ali and colleagues reported no additional analgesic benefit from adding acetaminophen (paracetamol) or hydromorphone to ibuprofen for children with acute musculoskeletal injuries. In all groups, the ibuprofen dose was 10 mg/kg and the acetaminophen dose was 15 mg/kg, with pain assessed 60 minutes after drug administration. Pain scores did not differ between ibuprofen monotherapy and either combination (ibuprofen plus acetaminophen or ibuprofen plus hydromorphone).
Acetaminophen (Paracetamol) or Opioid Plus Ibuprofen for Children’s Musculoskeletal Injury
https://jamanetwork.com/journals/jama/fullarticle/2849338
To the Editor Dr Ali and colleagues reported results from 2 randomized clinical trials evaluating whether adding acetaminophen (paracetamol) or hydromorphone to ibuprofen improves analgesia for children with acute nonoperative musculoskeletal injury. In pooled analyses, pain scores at 60 minutes were similar across groups, whereas adverse events were more frequent with hydromorphone. These findings are timely given pediatric opioid stewardship policies and recent clinical guidance that encourages nonopioid-first strategies and cautious outpatient opioid prescribing for acute pain in children.
https://jamanetwork.com/journals/jama/fullarticle/2849338
To the Editor Dr Ali and colleagues reported results from 2 randomized clinical trials evaluating whether adding acetaminophen (paracetamol) or hydromorphone to ibuprofen improves analgesia for children with acute nonoperative musculoskeletal injury. In pooled analyses, pain scores at 60 minutes were similar across groups, whereas adverse events were more frequent with hydromorphone. These findings are timely given pediatric opioid stewardship policies and recent clinical guidance that encourages nonopioid-first strategies and cautious outpatient opioid prescribing for acute pain in children.
A Healthy Dialogue With Gil Rabinovici
https://jamanetwork.com/journals/jama/fullarticle/2849336
JAMA Senior Editor Derek C. Angus, MD, MPH, spoke with Gil Rabinovici, MD, a neurologist and director of the University of California San Francisco Alzheimer Disease Research Center, about the latest developments in dementia and Alzheimer disease research.
https://jamanetwork.com/journals/jama/fullarticle/2849336
JAMA Senior Editor Derek C. Angus, MD, MPH, spoke with Gil Rabinovici, MD, a neurologist and director of the University of California San Francisco Alzheimer Disease Research Center, about the latest developments in dementia and Alzheimer disease research.
The CRT-Estimands Framework for Cluster Randomized Trials
https://jamanetwork.com/journals/jama/fullarticle/2849439
This Viewpoint discusses some specific challenges in defining estimands for cluster randomized trials and illustrates how the CRT-Estimands Framework can be applied to improve the interpretation of trial results.
https://jamanetwork.com/journals/jama/fullarticle/2849439
This Viewpoint discusses some specific challenges in defining estimands for cluster randomized trials and illustrates how the CRT-Estimands Framework can be applied to improve the interpretation of trial results.