FDA Approves New Medication for Agitation Associated With Dementia
https://jamanetwork.com/journals/jama/fullarticle/2849527
The US Food and Drug Administration (FDA) approved a new medication to treat agitation associated with dementia due to Alzheimer disease.
https://jamanetwork.com/journals/jama/fullarticle/2849527
The US Food and Drug Administration (FDA) approved a new medication to treat agitation associated with dementia due to Alzheimer disease.
Audio Highlights May 22, 2026
https://jamanetwork.com/journals/jama/fullarticle/2849627
Listen to the JAMA Editor’s Summary for an overview and discussion of the important articles appearing in JAMA.
https://jamanetwork.com/journals/jama/fullarticle/2849627
Listen to the JAMA Editor’s Summary for an overview and discussion of the important articles appearing in JAMA.
Measles Raging in Bangladesh
https://jamanetwork.com/journals/jama/fullarticle/2849520
This Medical News article discusses a large measles outbreak in the populous South Asian country and the global implications amid declines in vaccination.
https://jamanetwork.com/journals/jama/fullarticle/2849520
This Medical News article discusses a large measles outbreak in the populous South Asian country and the global implications amid declines in vaccination.
In Remembrance of Eugene Braunwald
https://jamanetwork.com/journals/jama/fullarticle/2849521
This Medical News article discusses the life and legacy of legendary cardiologist Eugene Braunwald, MD, who died on April 22, 2026.
https://jamanetwork.com/journals/jama/fullarticle/2849521
This Medical News article discusses the life and legacy of legendary cardiologist Eugene Braunwald, MD, who died on April 22, 2026.
Aberrant Left-to-Right Fusion of the Oculomotor Nerve
https://jamanetwork.com/journals/jamaneurology/fullarticle/2849575
This case report describes a 2-year-old girl with congenital ptosis of the left eye, large-angle exotropia, adduction deficit of the left eye, and abduction deficit of the right eye.
https://jamanetwork.com/journals/jamaneurology/fullarticle/2849575
This case report describes a 2-year-old girl with congenital ptosis of the left eye, large-angle exotropia, adduction deficit of the left eye, and abduction deficit of the right eye.
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Plasma eMTBR-tau243 and %p-tau217 for Biological Staging of Alzheimer Disease
https://jamanetwork.com/journals/jamaneurology/fullarticle/2849574
This longitudinal study develops and validates a blood plasma–based biological staging model for Alzheimer disease that closely mirrors an amyloid and tau positron emission tomography–based staging system.
https://jamanetwork.com/journals/jamaneurology/fullarticle/2849574
This longitudinal study develops and validates a blood plasma–based biological staging model for Alzheimer disease that closely mirrors an amyloid and tau positron emission tomography–based staging system.
Efficacy and Safety of Ecopipam for Tourette Syndrome
https://jamanetwork.com/journals/jamaneurology/fullarticle/2849573
This randomized clinical trial evaluates the safety and maintenance of effect of ecopipam, a selective dopamine D1 receptor antagonist, for up to 24 weeks for children, adolescents, and adults with Tourette syndrome.
https://jamanetwork.com/journals/jamaneurology/fullarticle/2849573
This randomized clinical trial evaluates the safety and maintenance of effect of ecopipam, a selective dopamine D1 receptor antagonist, for up to 24 weeks for children, adolescents, and adults with Tourette syndrome.
Effect of Electroacupuncture on Postherpetic Neuralgia
https://jamanetwork.com/journals/jamaneurology/fullarticle/2849572
This randomized clinical trial attempts to determine whether electroacupuncture reduces pain severity compared with sham electroacupuncture and evaluate its safety in patients with postherpetic neuralgia.
https://jamanetwork.com/journals/jamaneurology/fullarticle/2849572
This randomized clinical trial attempts to determine whether electroacupuncture reduces pain severity compared with sham electroacupuncture and evaluate its safety in patients with postherpetic neuralgia.
Neurological Teleconsultations in General Practice
https://jamanetwork.com/journals/jamaneurology/fullarticle/2849571
This stepped-wedge cluster randomized clinical trial evaluates whether teleneurology services in rural primary care in northeast Germany increased the proportion of patients with neurological symptoms or signs managed solely in general practice.
https://jamanetwork.com/journals/jamaneurology/fullarticle/2849571
This stepped-wedge cluster randomized clinical trial evaluates whether teleneurology services in rural primary care in northeast Germany increased the proportion of patients with neurological symptoms or signs managed solely in general practice.
A Low-Voltage Electrocardiogram
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2849093
This case report describes a woman in her 60s who had an inferior wall myocardial infarction 1 year prior and presented to the emergency department with worsening dyspnea and anasarca for the past 2 months.
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2849093
This case report describes a woman in her 60s who had an inferior wall myocardial infarction 1 year prior and presented to the emergency department with worsening dyspnea and anasarca for the past 2 months.
Finding Meaning in Medication Management in Dementia
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2849091
Most family caregivers assist with and worry about medication management tasks. Growden and colleagues draw on the qualitative component of the Living Alone With Cognitive Impairment Project to explore how older adults living alone with cognitive impairment and their family members or friends (social contacts) manage medications. They use inductive-deductive thematic analysis to analyze longitudinal interview data from a large, diverse sample of 116 older adults and 54 social contacts. Their findings can inform the development of clinical and policy interventions to support medication management at the individual, interpersonal and/or relational, and system and/or policy levels. Through this qualitative research, Growden and colleagues give voice to the often overlooked population of older adults living independently with dementia.
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2849091
Most family caregivers assist with and worry about medication management tasks. Growden and colleagues draw on the qualitative component of the Living Alone With Cognitive Impairment Project to explore how older adults living alone with cognitive impairment and their family members or friends (social contacts) manage medications. They use inductive-deductive thematic analysis to analyze longitudinal interview data from a large, diverse sample of 116 older adults and 54 social contacts. Their findings can inform the development of clinical and policy interventions to support medication management at the individual, interpersonal and/or relational, and system and/or policy levels. Through this qualitative research, Growden and colleagues give voice to the often overlooked population of older adults living independently with dementia.
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Waiting Periods and the Maturation of a Policy Evidence Base
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2849090
Swanson and colleagues provide an important contribution to a small but growing evidence base on the effects of firearm purchase waiting periods. Using administrative data from 35 million California residents covered by the Longitudinal Study of Handgun Ownership and Transfer (LongSHOT), the authors examine homicide risk among approximately 1 million first-time handgun purchasers and their cohabitants during the mandatory 10-day waiting period, comparing outcomes with a 4-to-1 matched group of nonpurchasers in the state. The central finding is striking: between 2004 and 2021, 0 homicides occurred among purchasers or their cohabitants during the waiting period. Critics of waiting periods have long characterized them as an arbitrary inconvenience that burdens law-abiding gun owners without meaningfully affecting public safety. This finding—that first-time purchasers face no elevated homicide risk during the delay—speaks to that concern, suggesting that California’s 10-day waiting period does not come at a measurable cost to purchaser safety. With only 13 states currently imposing waiting periods, evidence on this policy is especially valuable.
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2849090
Swanson and colleagues provide an important contribution to a small but growing evidence base on the effects of firearm purchase waiting periods. Using administrative data from 35 million California residents covered by the Longitudinal Study of Handgun Ownership and Transfer (LongSHOT), the authors examine homicide risk among approximately 1 million first-time handgun purchasers and their cohabitants during the mandatory 10-day waiting period, comparing outcomes with a 4-to-1 matched group of nonpurchasers in the state. The central finding is striking: between 2004 and 2021, 0 homicides occurred among purchasers or their cohabitants during the waiting period. Critics of waiting periods have long characterized them as an arbitrary inconvenience that burdens law-abiding gun owners without meaningfully affecting public safety. This finding—that first-time purchasers face no elevated homicide risk during the delay—speaks to that concern, suggesting that California’s 10-day waiting period does not come at a measurable cost to purchaser safety. With only 13 states currently imposing waiting periods, evidence on this policy is especially valuable.
Homicide Risk During Waiting Period Among Handgun Purchasers
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2849089
This cohort study assesses the occurrence and risk of death by homicide involving gun purchasers and their cohabitants during a mandatory period between the purchase and physical possession of the gun.
https://jamanetwork.com/journals/jamainternalmedicine/fullarticle/2849089
This cohort study assesses the occurrence and risk of death by homicide involving gun purchasers and their cohabitants during a mandatory period between the purchase and physical possession of the gun.
The MV Hondius Hantavirus Outbreak
https://jamanetwork.com/journals/jama/fullarticle/2849730
This Perspective explores the hantavirus outbreak aboard the MV Hondius, examining how it revealed vulnerabilities in global health preparedness and outlining reforms to improve operational authority and coordination across jurisdictions.
https://jamanetwork.com/journals/jama/fullarticle/2849730
This Perspective explores the hantavirus outbreak aboard the MV Hondius, examining how it revealed vulnerabilities in global health preparedness and outlining reforms to improve operational authority and coordination across jurisdictions.
Hearing Aids for Adults With Mild to Moderate Hearing Loss
https://jamanetwork.com/journals/jama/fullarticle/2849449
This JAMA Insights discusses hearing aids for adults with mild to moderate hearing loss, including hearing aid function and limitations and prescription vs over-the-counter hearing aid devices.
https://jamanetwork.com/journals/jama/fullarticle/2849449
This JAMA Insights discusses hearing aids for adults with mild to moderate hearing loss, including hearing aid function and limitations and prescription vs over-the-counter hearing aid devices.
Acute Non–Large Vessel Occlusion After Ischemic Stroke
https://jamanetwork.com/journals/jama/fullarticle/2849448
To the Editor We read with interest the Tenecteplase for Acute Non–Large Vessel Occlusion in the Extended Time Window (OPTION) trial, which evaluated intravenous tenecteplase administered between 4.5 and 24 hours after ischemic stroke onset in patients selected by computed tomographic (CT) perfusion imaging. Although the study addresses an important question in acute stroke care, its findings warrant cautious interpretation in light of safety considerations and clinical context.
https://jamanetwork.com/journals/jama/fullarticle/2849448
To the Editor We read with interest the Tenecteplase for Acute Non–Large Vessel Occlusion in the Extended Time Window (OPTION) trial, which evaluated intravenous tenecteplase administered between 4.5 and 24 hours after ischemic stroke onset in patients selected by computed tomographic (CT) perfusion imaging. Although the study addresses an important question in acute stroke care, its findings warrant cautious interpretation in light of safety considerations and clinical context.
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Tenecteplase for Acute Non–Large Vessel Occlusion After Ischemic Stroke—Reply
https://jamanetwork.com/journals/jama/fullarticle/2849447
In Reply We thank Drs Morelli and colleagues for their thoughtful comments about the OPTION trial.
https://jamanetwork.com/journals/jama/fullarticle/2849447
In Reply We thank Drs Morelli and colleagues for their thoughtful comments about the OPTION trial.
After Sunstroke
https://jamanetwork.com/journals/jama/fullarticle/2849446
The heat of an olive grove in August staggers and stuns—cicadas drilling, the tall grass baked too dry for mulch.
https://jamanetwork.com/journals/jama/fullarticle/2849446
The heat of an olive grove in August staggers and stuns—cicadas drilling, the tall grass baked too dry for mulch.
Sunstroke: The Madness of the Maenads and Poetry
https://jamanetwork.com/journals/jama/fullarticle/2849445
Among poetry’s applications in modern medicine is to reconnect clinicians to ancient healing rituals. In “After Sunstroke,” the speaker searingly recalls the Dionysian cult of ancient Greece and specifically its association with the maenads, female followers of the god of ecstasy who were believed to possess healing powers expressed in the catharsis of his worship with libation and dance. We hear the throb of music in the poem’s iambic rhythm, with the speaker also evoking the altered sensorium of sunstroke in a further reference to the madness of the maenads’ writhing and moaning. To the ancient Greeks, such rituals were community gatherings that themselves catalyzed healing; a similar impulse to (re)join in human communion is acutely felt here after the speaker recounts his isolating, hallucinatory symptoms of “I could glean/only goat bleat and the untuned bells/of a mad song…//…rereading the same/dense page about the German troops/in snow, till I would almost plead//to join them getting picked apart.” What feels like it could culminate in “certain death” is met instead by the healing physicality of the maenads, who seem to assuage not only the speaker’s, but even all humanity’s, suffering—that “piercing ring of heat”—in suffusing it with their “raised arms and wild hair.” Their frantic motion and headlong rush toward release is reminiscent, perhaps, of the hectic days of clinicians on the verge of burnout, always going beyond the possible in the quest to heal. Thus poetry aids in the timeless struggle to ease our patients’, and perhaps even our own, debasement by illness.
https://jamanetwork.com/journals/jama/fullarticle/2849445
Among poetry’s applications in modern medicine is to reconnect clinicians to ancient healing rituals. In “After Sunstroke,” the speaker searingly recalls the Dionysian cult of ancient Greece and specifically its association with the maenads, female followers of the god of ecstasy who were believed to possess healing powers expressed in the catharsis of his worship with libation and dance. We hear the throb of music in the poem’s iambic rhythm, with the speaker also evoking the altered sensorium of sunstroke in a further reference to the madness of the maenads’ writhing and moaning. To the ancient Greeks, such rituals were community gatherings that themselves catalyzed healing; a similar impulse to (re)join in human communion is acutely felt here after the speaker recounts his isolating, hallucinatory symptoms of “I could glean/only goat bleat and the untuned bells/of a mad song…//…rereading the same/dense page about the German troops/in snow, till I would almost plead//to join them getting picked apart.” What feels like it could culminate in “certain death” is met instead by the healing physicality of the maenads, who seem to assuage not only the speaker’s, but even all humanity’s, suffering—that “piercing ring of heat”—in suffusing it with their “raised arms and wild hair.” Their frantic motion and headlong rush toward release is reminiscent, perhaps, of the hectic days of clinicians on the verge of burnout, always going beyond the possible in the quest to heal. Thus poetry aids in the timeless struggle to ease our patients’, and perhaps even our own, debasement by illness.
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Clinical Diagnosis of Calcium Release Deficiency Syndrome in a Family With Sudden Cardiac Death
https://jamanetwork.com/journals/jamacardiology/fullarticle/2849618
This case series explores how the novel calcium release deficiency syndrome provocation test can clinically establish the diagnosis in a family with unexplained sudden cardiac arrest and death.
https://jamanetwork.com/journals/jamacardiology/fullarticle/2849618
This case series explores how the novel calcium release deficiency syndrome provocation test can clinically establish the diagnosis in a family with unexplained sudden cardiac arrest and death.
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