Gilbert’s Syndrome:
Mild decrease in glucuronyltransferase activity.
Crigler-Najjar Syndrome:
Complete deficiency of glucuronyltransferase.
Both cause abnormal metabolism of bilirubin❗️
Mild decrease in glucuronyltransferase activity.
Crigler-Najjar Syndrome:
Complete deficiency of glucuronyltransferase.
Both cause abnormal metabolism of bilirubin❗️
Gallstones Types:
1️⃣Cholesterol (20%):
Occur either as solitary, two stones, or as multiple mulberry stones associated with a strawberry gallbladder.
2️⃣Bile pigment (5%):
Small, black, irregular, multiple, gritty and fragile.
3️⃣Mixed (75%):
Multiple. The cut surface is laminated with alternate dark and light zones of pigment and cholesterol respectively.
1️⃣Cholesterol (20%):
Occur either as solitary, two stones, or as multiple mulberry stones associated with a strawberry gallbladder.
2️⃣Bile pigment (5%):
Small, black, irregular, multiple, gritty and fragile.
3️⃣Mixed (75%):
Multiple. The cut surface is laminated with alternate dark and light zones of pigment and cholesterol respectively.
🔴
Retroperitoneal structures (SAD PUCKER):
Suprarenal glands.
Aorta & IVC.
Duodenum (2nd through 4th parts).
Pancreas (except tail).
Ureters.
Colon (descending & ascending).
Kidneys.
Esophagus (thoracic portion).
Rectum (partially).
Retroperitoneal structures (SAD PUCKER):
Suprarenal glands.
Aorta & IVC.
Duodenum (2nd through 4th parts).
Pancreas (except tail).
Ureters.
Colon (descending & ascending).
Kidneys.
Esophagus (thoracic portion).
Rectum (partially).
Poor Prognostic Indicators in Rheumatoid Arthritis:
▪️High RF titers.
▪️Subcutaneous nodules.
▪️Erosive arthritis.
▪️Autoantibodies to RF.
▪️High RF titers.
▪️Subcutaneous nodules.
▪️Erosive arthritis.
▪️Autoantibodies to RF.
🔴
5Ps of Compartment Syndrome:
Pain.
Paresthesia.
Pallor.
Pulselessness.
Poikilothermia.
5Ps of Compartment Syndrome:
Pain.
Paresthesia.
Pallor.
Pulselessness.
Poikilothermia.
Pulmonary Hypertension:
It is defined as a mean pulmonary artery pressure >25 mmHg at rest. Normal mean pulmonary artery pressure is 12–15 mmHg❗️
It is defined as a mean pulmonary artery pressure >25 mmHg at rest. Normal mean pulmonary artery pressure is 12–15 mmHg❗️
🔹Lower Urinary Tract Symptoms🔹
Storage Sx (FUND)
Frequency
Urgency
Nocturia
Dysuria
Voiding Sx (SHED)
Stream changes
Hesitancy
Incomplete Emptying
Dribbling
Storage Sx (FUND)
Frequency
Urgency
Nocturia
Dysuria
Voiding Sx (SHED)
Stream changes
Hesitancy
Incomplete Emptying
Dribbling
🔴
Rotator cuff muscles: (SItS)
Supraspinatus.
Infraspinatus.
teres minor.
Subscapularis.
Rotator cuff muscles: (SItS)
Supraspinatus.
Infraspinatus.
teres minor.
Subscapularis.
Wilson's disease:
🔸It is a rare autosomal recessive disorder of copper metabolism. There is a deficiency of caeruloplasmin protein, which binds copper, resulting in copper deposition in various organs, especially in the liver and the basal ganglia in the brain.
🔸It is a rare autosomal recessive disorder of copper metabolism. There is a deficiency of caeruloplasmin protein, which binds copper, resulting in copper deposition in various organs, especially in the liver and the basal ganglia in the brain.
Typical Anginal Chest Pain:
🔸Substernal.
🔸Worse with exertion.
🔸Better with rest or nitroglycerin.
🔸Substernal.
🔸Worse with exertion.
🔸Better with rest or nitroglycerin.
⬆️AST & ALT: Think hepatocellular injury.
AST > ALT: alcohol-related.
ALT > AST: viral, drug, toxin.
⬆️ALP & GGT: Think biliary tree obstruction.
AST > ALT: alcohol-related.
ALT > AST: viral, drug, toxin.
⬆️ALP & GGT: Think biliary tree obstruction.
🔴
Cellulitis:
Non-suppurative infection of skin and subcutaneous tissues. (indistinct borders)
Erysipelas:
Acute skin infection that is more superficial than cellulitis. (sharp borders)
Cellulitis:
Non-suppurative infection of skin and subcutaneous tissues. (indistinct borders)
Erysipelas:
Acute skin infection that is more superficial than cellulitis. (sharp borders)
Barrett Esophagus:
🔹Specialized intestinal metaplasia-Replacement of nonkeratinized stratified squamous epithelium with intestinal epithelium (nonciliated columnar with goblet cells) in distal esophagus.
🔹Due to chronic gastroesophageal reflux (GERD).
🔹Associated with ⬆️ risk of esophageal adenocarcinoma.
🔹Specialized intestinal metaplasia-Replacement of nonkeratinized stratified squamous epithelium with intestinal epithelium (nonciliated columnar with goblet cells) in distal esophagus.
🔹Due to chronic gastroesophageal reflux (GERD).
🔹Associated with ⬆️ risk of esophageal adenocarcinoma.