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🇩🇪 A German biotech has big ambitions in cancer. Now it needs to get a medicine approved

German biotechnology company Immatics is developing an experimental cell therapy targeting PRAME, a protein expressed in more than 50 cancer types. The treatment modifies a patient’s own T cells to recognize and attack cancer cells carrying this target, potentially opening new treatment options for tumors that have been difficult to treat with existing immunotherapies.

In an early-phase clinical trial involving 16 patients with uveal melanoma, a rare form of eye cancer, all patients experienced tumor shrinkage following treatment. These preliminary results suggest that PRAME-targeted therapy could have potential beyond melanoma, including in ovarian and pancreatic cancers.

Immatics is now working to advance its lead candidate toward regulatory approval and expand the approach to additional solid tumors. The therapy remains investigational, and further clinical trials are needed to confirm its safety and efficacy.

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🤑 U.S. Bank’s stablecoin pilot sets a new standard for cross-border payments in which money moves faster without trade-offs

Denelle Dixon, CEO and Executive Director of the SDF, explains why Stellar was the obvious fit.

When users win, we all win 🏆

#Stellar

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⚠️ PHP Armageddon: OpenAI, Google’s Wiz find ancient holes, panicking the internet

The U.S. National Security Agency’s sent out an alarming warning that two critical holes had been found in PHP, with patches already issued by the PHP Foundation.

PHP is a server-side programming language so widely used for web applications that it powers roughly 70% of the websites on the internet; by some accounts, that’s more than 33 million sites. It is also used by popular content management systems like WordPress.

The NSA warned that these holes are so severe that if a website can’t be patched immediately, it should be pulled off the web until it can be. The holes allow attackers to infiltrate the server’s file system or a database that may be used by the web app.

Interestingly, these holes have been tucked away in all versions of PHP since version 5, which was released in 2004. Websites not running relatively current versions of PHP will have some updating work to do, as PHP 8.1 and older versions are no longer supported. The recommendation is to update the web server to the current version of PHP, which is 8.5.12.

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⚡️🇺🇸 Trump says fraud investigations make 'very big dent' in overseas scams

President Donald Trump said his administration has made a "very big dent" in scams by foreign criminal networks that lure Americans ​into fraudulent investments. FBI Director Kash Patel said his agency had taken down 20 scam compounds throughout the world.

"Federal law enforcement has been able to warn ​over 10,000 Americans targeted for victimization, and we've prevented $1.6 billion in losses — at least — this year," ​Trump said.

"We will work tirelessly to help recover what has been stolen and dismantle the criminal networks that prey on our people."


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🤑 Stellar Ramps Up Quantum Readiness With Bell Upgrade

Stellar
is stepping up its quantum-readiness efforts, and the latest Bell upgrade could mark another important milestone in the network’s long-term security strategy.🔐

As concerns grow over the potential threat quantum computing poses to blockchain technology, Stellar’s push to prepare for the next generation of computing could strengthen its appeal as a forward-looking blockchain ecosystem.

🚀 Stellar outlined the goals of its upcoming Bell Protocol upgrade, highlighting plans to support business-ready smart accounts at scale, begin work on quantum-safe signatures, and improve ledger performance.

🗓 The upgrade is expected next month, with November 3 and November 23, 2026, emerging as potential testnet and mainnet activation dates, respectively.

❗️If implemented as planned, the upgrade could mark an important step in Stellar’s long-term push to strengthen its infrastructure and prepare for emerging security challenges.

In June 2026, Stellar introduced its Quantum Preparedness Plan (QPP), outlining its strategy to transition the network toward quantum-safe cryptography. The initiative reflects Stellar’s efforts to address potential future threats from quantum computing while strengthening the network’s long-term security and resilience.

➡️ Under Stellar’s quantum roadmap, every account is expected to be able to add a quantum-safe signer through a native protocol upgrade by the end of 2027, without changing its existing address or transaction history.

➡️ Meanwhile, enterprise wallets could begin adopting quantum-safe signing as early as 2026 through Soroban smart contract accounts, allowing businesses to prepare for emerging quantum threats ahead of the broader network transition.

#Stellar

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🤖 Unitree Robotics unveils its new humanoid bodyguard robot

Unitree Robotics
launched the H2-X Kung Fu Legend Guardian, a humanoid built on its 1.8-meter H2 platform, showcasing spinning kicks, high jumps, backflips, car-denting strikes, and lifting a car's front end in a rescue demo — all with up to 8 hours of battery life.

#BRICS

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🧑‍⚖️ Meta Ordered to Pay $25 Billion for Deceiving Users on Privacy

New Mexico sued Meta in 2021 over a scandal involving the political consulting firm Cambridge Analytica, saying the social media company had misled users with its public statements about their data privacy.

Last month, after a two-week trial, a jury in the State District Court in Santa Fe ruled against Meta, saying the company had committed 43 million violations of New Mexico’s consumer protection laws. Each violation carried a penalty of up to $5,000.

Judge Francis J. Mathew of the Santa Fe court issued the landmark penalty, writing that the company and its executives purposefully misled the public.

“The harm in this matter is difficult to overstate, and goes to the heart of Facebook’s basic business proposition,” — Judge Mathew wrote in a 20-page judgment.

He said the “extraordinary number of willful violations” that repeated over years “support the highest level of penalty.”


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💸 Elon Musk says money will be 'irrelevant' if his vision of a multiplanetary future comes true

Musk predicted that advances in robotics and space travel will create a multiplanetary economy, at which point "money becomes irrelevant" and "conventional currency will not matter."

“I think currency will be measured in fundamental physics metrics like, you know, power, like wattage and tonnage, mass and energy.”

“There won't be anything that humans can do that the AI and the robots can't do better. People will likely turn to hobbies like growing their own fruits and vegetables, or making art, to find purpose in life,” — he said.


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⚡️🇶🇦🇺🇸Qatar Agrees to Buy US LNG to 2054

QatarEnergy signed a deal with Cheniere Energy Inc. to buy 4 million tons a year of liquefied natural gas through 2054, the Middle East nation’s first such US offtake deal.

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⚡️🤑 Arf and Ripple Partner to Bring Settlement Liquidity to the XRP Ledger

Arf is bringing RLUSD-powered settlement liquidity to licensed cross-border payment companies on the XRP Ledger. Arf helped pioneer PayFi and has scaled to around $10 billion annually in global settlement volumes. As XRPL's native lending infrastructure comes online, it will become part of that settlement liquidity. 🚀

“Payment companies need capital to keep money moving while they wait for funds to settle. We’re meeting that need at scale, with $10 billion in annual settlement volume and capital turning over four times a month.

Through this partnership with Ripple, we’re bringing stablecoin working capital to the XRP Ledger to help payment companies bridge that gap and support more payment volume,”– Ali Erhat Nalbant, Co-founder and CEO at Arf, said.


👉 As the first phase of the partnership, Arf will provide direct RLUSD settlement liquidity on the XRP Ledger. Arf’s short-duration settlement liquidity is typically repaid within one to five days as cross-border payments settle, allowing capital to be repeatedly deployed against real payment flows.

👉 Once XRPL’s native lending infrastructure becomes available, Arf plans to bring more of its settlement liquidity activity directly onto the protocol. That means the capital supporting this liquidity can be managed onchain and deployed through native lending functionality, while Arf continues to handle underwriting and working capital decisions offchain.

👉 The infrastructure includes Single Asset Vaults, which allow capital to be pooled and managed onchain, and the Lending Protocol, which enables that capital to be extended as structured loans. The proposed capabilities are subject to XRPL’s amendment process before they can become available on mainnet.

❗️Payment companies do not need to operate onchain to benefit. Arf allows licensed financial institutions to manage their treasuries between fiat and stablecoins, supported by Arf’s bank accounts in major financial hubs, while the underlying blockchain infrastructure operates behind the scenes.

Arf has already built against the proposed protocol, providing a concrete implementation of how the Lending Protocol can support institutional settlement financing.

#Stellar

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🤖 1000 human mathematicians pledge to shun AI in their research

More than 1000 mathematicians have pledged not to work for AI companies and to avoid using their models – to varying extents – in their research. The move comes amid a growing backlash against the way AI companies have used their models to solve thorny mathematical problems, many of which had stumped humans for decades.

The Association of Human Mathematicians (AHM) was created in the wake of controversial discoveries from AI companies, such as the release of 722 papers in one fell swoop by OpenAI earlier this month. Membership now stretches to more than 1000 people, including professors and PhD students.

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🤖 Could China’s 100-channel single-photon detector enable broadband quantum internet?

Chinese scientists have developed a 100-channel single-photon detector, a breakthrough promising to pave the way for broadband quantum networks.

State-of-the-art single-photon detectors – essential components underpinning photonic quantum technologies – could previously support a maximum of 32 detection channels for photon signals.

Now, a newly developed interconnect scheme by a Shanghai-based team has broken this bottleneck, supporting more than 100 detection channels while maintaining accurate and stable operation.

“This work establishes a robust and scalable infrastructure, paving the way for large-scale quantum photonic applications,” — the authors said.


#BRICS

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🚘 G.M. Hopes to Design New Cars in as Little as 2 Years Using A.I.

General Motors plans to lean into AI and vehicle software for future growth and development amid increasing competition abroad from Chinese automakers and a tougher U.S. market.

GM also reconfirmed that by 2028, it wants to have eyes-off highway driving, or “personal autonomy,” that will let drivers take their attention off the road. The automaker said that technology would start with the Cadillac Escalade IQ EV before rolling out to other, more high-volume models.

“All of these developments are building us the car of the future,” — CEO Mary Barra said.


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🧑‍⚖️ Rep. Eugene Vindman proposes keeping data center power costs off household electric bills

As data centers expand, Representative Eugene Vindman wants the companies behind them to pay the added costs of supplying their electricity — rather than passing those expenses to other utility customers.

The Democrat representing Virginia’s 7th District introduced the Make Data Centers Pay Act, which would amend federal law to prevent qualifying data centers’ power and infrastructure costs from being shifted onto households and small businesses.

"Hardworking Americans should not have to pay higher electricity bills to subsidize some of the largest and most energy-intensive data centers in the world,"— Vindman said.


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🧑‍⚖️ Blockchain Association Urges Congress to Reform US Crypto Tax Rules

Blockchain Association
has urged US congressional leaders to revise digital asset tax rules, arguing that existing requirements create uncertainty for taxpayers and compliance burdens for businesses.

📝 In an October 22 letter to Senate Majority Leader John Thune, Senate Minority Leader Chuck Schumer, House Speaker Mike Johnson and House Minority Leader Hakeem Jeffries, the industry group proposed changes to the tax treatment of stablecoins, staking rewards, broker reporting and transactions between crypto wallets.

🔘Blockchain Association proposed a de minimis exemption for digital asset transactions, which would allow certain low-value transactions to avoid tax-related burdens.

🔘The group also called for stablecoins to receive cash treatment for tax purposes and for relief from Form 1099-DA reporting requirements.

🔘The group proposed limiting broker reporting obligations to intermediaries that have custody or control of customer assets. Under its approach, non-custodial developers and infrastructure participants would be excluded from these requirements.

🔘The association said reporting rules should protect taxpayer privacy while supporting legitimate enforcement.

🔘It also proposed that transfers between a person’s own wallets, smart-contract interactions and transfers across blockchain networks should not trigger tax when the owner’s economic ownership and exposure remain unchanged.

🔘Blockchain Association called for mining and staking rewards to be treated as self-created property, with tax generally due when the assets are sold or otherwise disposed of rather than when the rewards are received.

🔘The group urged Congress to clarify that staking does not constitute impermissible business activity for grantor trusts, partnerships and regulated investment vehicles. It also proposed recognizing staking rewards as permissible investment income and allowing Americans to hold digital assets in retirement accounts.

🔘Blockchain Association urged Congress to establish a statutory safe harbor for foreign persons trading digital assets on US exchanges, consistent with the treatment of securities and commodities.

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⚡️🛰 SpaceX in Talks to Access 80,000 Cell Sites for New Network

SpaceX aims to secure a minimum of 80,000 cell sites across the US, and it’s in talks with at least one major cellular infrastructure company to reach that goal.

The agreements would solidify the rocket and satellite giant’s path toward building a fourth nationwide wireless carrier. One of the companies they’re in talks with is Crown Castle Inc., which, along with American Tower Corp. and Vertical Bridge Holdings, are among the largest owners of cellular towers.

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