Researchers have long associated per- and polyfluoroalkyl substances (PFAS), commonly known as “forever chemicals,” to certain severe birth defects. New research now provides the first clear molecular explanation, showing how one PFAS can trigger craniofacial abnormalities before birth.
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#PFAS #BirthDefects #CraniofacialResearch
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#PFAS #BirthDefects #CraniofacialResearch
CU Anschutz Medical Campus
How One ‘Forever Chemical’ Can Disrupt a Baby’s Facial Development
How One ‘Forever Chemical’ Can Disrupt a Baby’s Facial Development
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Science News
Researchers have long associated per- and polyfluoroalkyl substances (PFAS), commonly known as “forever chemicals,” to certain severe birth defects. New research now provides the first clear molecular explanation, showing how one PFAS can trigger craniofacial…
🔬 New research offers the first molecular explanation for how "forever chemicals" like PFDA cause birth defects, specifically craniofacial abnormalities.
🔬 The study, published in ACS Chemical Research in Toxicology, found that PFDA disrupts a crucial enzyme (CYP26A1) that regulates retinoic acid, a molecule vital for face and head development, leading to underdeveloped eyes and abnormal jaws.
🔬 Researchers tested 139 PFAS compounds and identified PFDA as the most toxic to fetal craniofacial development, with even tiny amounts causing visible facial changes and a 10% risk increase at extremely low exposure levels.
#PFAS #EnvironmentalHealth #BirthDefects
🔬 The study, published in ACS Chemical Research in Toxicology, found that PFDA disrupts a crucial enzyme (CYP26A1) that regulates retinoic acid, a molecule vital for face and head development, leading to underdeveloped eyes and abnormal jaws.
🔬 Researchers tested 139 PFAS compounds and identified PFDA as the most toxic to fetal craniofacial development, with even tiny amounts causing visible facial changes and a 10% risk increase at extremely low exposure levels.
#PFAS #EnvironmentalHealth #BirthDefects