Chronic stress causes progressive bone loss through sustained glucocorticoid (cortisol) receptor signaling. Effects worsen with prolonged exposure and show limited recovery.
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#ChronicStress #BoneLoss #Cortisol #Glucocorticoids #BoneHealth
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#ChronicStress #BoneLoss #Cortisol #Glucocorticoids #BoneHealth
MDPI
Chronic Stress Leads to Time-Dependent Bone Loss Through HPA Axis Dysregulation and GR Nuclear Translocation Disorder
Chronic stress and sustained hypothalamic–pituitary–adrenal (HPA) axis activation are major contributors to metabolic bone diseases, including osteoporosis. However, the precise molecular mechanisms by which chronic stress-induced HPA axis dysregulation drives…
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