Intestinal infections cause antigen-specific CD4+ T cells to migrate from the gut and establish long-lived memory in the brain and meninges, a mechanism the authors link to anxiety and depression in inflammatory bowel disease
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#Immunology #GutBrainAxis #CD4Tcells
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#Immunology #GutBrainAxis #CD4Tcells
Nature
Intestinal infections establish antigen-specific, long-lived memory CD4 [+] T cells in the brain and meninges
Nature Neuroscience - Intestinal CD4+ T cells migrate to the dura and brain following gut infection with bacteria or parasites, establishing a long-lived memory population capable of proliferation...