Growing human organs inside animals keeps failing because the host embryo's earliest immune cells eat the donor cells alive. Researchers found three ways to shut that off — and the success rate for growing a rat pancreas inside a mouse jumped from 38% to 73%.
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#OrganGeneration #ChimericResearch #Bioengineering
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#OrganGeneration #ChimericResearch #Bioengineering
Cell
Xenophagocytosis blockade enhances interspecies chimerism
Host macrophages limit interspecies chimerism via xenophagocytosis, whereby stressed
donor cells expose phosphatidylserine as an “eat-me” signal. Blocking xenophagocytosis
successfully enhances donor chimerism and enables efficient exogenic organogenesis.
donor cells expose phosphatidylserine as an “eat-me” signal. Blocking xenophagocytosis
successfully enhances donor chimerism and enables efficient exogenic organogenesis.
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