Exercise worsens brain metabolism in ME/CFS by depleting metabolites, disrupting folate metabolism, and altering lipids and energy, contributing to cognitive dysfunction and post-exertional malaise.
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#MECFS #ExerciseImpact #BrainHealth #CognitiveDysfunction #PostExertionalMalaise
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#MECFS #ExerciseImpact #BrainHealth #CognitiveDysfunction #PostExertionalMalaise
MDPI
Exertional Exhaustion (Post-Exertional Malaise, PEM) Evaluated by the Effects of Exercise on Cerebrospinal Fluid Metabolomics–Lipidomics…
Post-exertional malaise (PEM) is a defining condition of myalgic encephalomyelitis (ME/CFS). The concept requires that a provocation causes disabling limitation of cognitive and functional effort (“fatigue”) that does not respond to rest. Cerebrospinal fluid…