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A single gene 🧬 shapes gut health and IBD risk: two studies reveal the gene PTPN2’s role in protecting the gut from harmful bacteria 🦠 linked to inflammatory bowel disease (IBD) Read Full Article #ptpn2 #guthealth #ibdrisk #microbiome #inflammation
🔬 Gene PTPN2 identified as key in gut defense against harmful bacteria linked to IBD. When it malfunctions, the gut becomes more vulnerable to infections and inflammation.

🦠 Studies from UC Riverside, led by Prof. Declan McCole, reveal faulty PTPN2 allows bacteria like AIEC to invade gut cells and damage the protective barrier, worsening IBD symptoms.

💊 Research in Gut Microbes (Dec 2025 issue) suggests JAK inhibitors, already used for IBD, may help limit harmful bacteria invasion in individuals with a genetic predisposition.

#IBD #GutHealth #MedicalResearch
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Science News
The anti‐inflammatory and antioxidant properties of dietary polyphenols 🛡️🍃 may mediate protective effects through modulation of gut microbiota 🦠, enhancement of intestinal barrier function 🚪, and regulation of immune responses 🧬, study finds 🔬 Read Full…
* 🍎 **Dietary Preferences Linked to IBD Risk:** A genetic study found that preferences for certain polyphenol-rich plant foods may influence the risk of inflammatory bowel disease (IBD).

* 🍊 **Protective Factors for Crohn's Disease:** Preferences for orange juice, lentils/beans, and melon were associated with a decreased risk of Crohn's disease (CD).

* 🌿 **Aniseed Preference Linked to Ulcerative Colitis Risk:** A genetic predisposition to prefer aniseed was found to independently increase the risk of ulcerative colitis (UC).

#IBD #CrohnsDisease #UlcerativeColitis

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Research has found patients with inflammatory bowel disease (IBD) face a significantly higher risk of psychiatric disorders starting two to three years before diagnosis and lasting up to a decade after

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#IBD #MentalHealth #CrohnsAndColitis
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Science News
A simple blood test may spot Crohn's and ulcerative colitis up to 10 years before diagnosis. Scientists studied 2,000 blood samples and found people who later got bowel disease had distinct antibody patterns, including more antibodies to the glandular fever…
🔬 Research indicates that specific antibody patterns in blood could predict the onset of Inflammatory Bowel Disease (IBD) up to 10 years before diagnosis, offering hope for earlier detection and potential prevention.

🔬 Scientists at the University Medical Centre Groningen and Icahn School of Medicine at Mount Sinai identified immune system warning signs that appear years before symptoms of Crohn's disease and ulcerative colitis manifest.

🔬 Analysis of blood samples from US military personnel revealed distinct antibody patterns, including those against Epstein-Barr virus (for Crohn's) and the body's own proteins (for ulcerative colitis), a decade before diagnosis.

#IBD #Gastroenterology #MedicalResearch