Study finds (R)-ketamine restores cognitive deficits induced by chronic social isolation
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#ketamine #cognitiverestoration #socialisolation #mentalhealth #neuroscience
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#ketamine #cognitiverestoration #socialisolation #mentalhealth #neuroscience
Nature
(R)-ketamine restores anterior insular cortex activity and cognitive deficits in social isolation-reared mice
Molecular Psychiatry - (R)-ketamine restores anterior insular cortex activity and cognitive deficits in social isolation-reared mice
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Ketamine changes the way our brains process touch, especially the difference between touch from ourselves versus someone else, and may blur the boundaries of self-perception. This offers new insights into how certain psychiatric symptoms related to self-awareness could be mirrored in the brain.
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#Ketamine #Neuroscience #MentalHealth #SelfPerception #TouchTherapy
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#Ketamine #Neuroscience #MentalHealth #SelfPerception #TouchTherapy
PsyPost
Neuroscience research sheds light on ketamine’s strange effect on our sense of touch
Researchers found that ketamine blurs the brain’s ability to distinguish between self- and other-produced touch, particularly in a brain area involved in social processing.
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Ketamine shows no significant advantage over placebo in treating severe depression, according to a new clinical trial. The findings suggest that earlier reports of its effectiveness may have been inflated by patient and clinician expectations. 💊😞
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#Ketamine #DepressionTreatment #ClinicalTrial #MentalHealth #PlaceboEffect
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#Ketamine #DepressionTreatment #ClinicalTrial #MentalHealth #PlaceboEffect
Jamanetwork
Serial Ketamine Infusions as Adjunctive Therapy to Inpatient Care for Depression: The KARMA-Dep 2 Randomized Clinical Trial
This randomized clinical trial evaluates outcomes following adjunctive ketamine infusions vs midazolam for depression.
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Ketamine and electroconvulsive therapy share same antidepressant mechanism 💊⚡️
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#Ketamine #ElectroconvulsiveTherapy #AntidepressantMechanism #MentalHealth #Neuropsychiatry
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#Ketamine #ElectroconvulsiveTherapy #AntidepressantMechanism #MentalHealth #Neuropsychiatry
Nature
Adenosine signalling drives antidepressant actions of ketamine and ECT
Nature - Adenosine signalling is identified as the central mechanism of action of the antidepressant effects of ketamine and electroconvulsive therapy, and newly developed analogues of ketamine...
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A nationwide study found that ketamine does not improve survival compared with etomidate and carries a higher risk of heart-related complications during emergency intubation. The findings provide long-awaited evidence to guide one of the most critical decisions emergency clinicians make. 🏥💉⚠️
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#EmergencyMedicine #Ketamine #Etomidate #ClinicalGuidelines #PatientSafety
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#EmergencyMedicine #Ketamine #Etomidate #ClinicalGuidelines #PatientSafety
CU Anschutz Medical Campus
National Trial: Ketamine Raises Heart Risk, No Survival Advantage Over Etomidate in Emergency Intubation
Ketamine vs. Etomidate: National Trial Reveals Key Safety Differences
Science News
Ketamine’s rapid relief of suicidal thoughts may be linked to an increase in morning cortisol. This specific hormonal boost persists for at least 24 hours after treatment.L Read Full Article #KetamineTherapy #MentalHealthResearch #CortisolBoost
🔬 A single dose of ketamine increased morning cortisol levels in patients with major depression and suicidal thoughts for at least 24 hours, according to a study published in the Journal of Affective Disorders.
🧠 The research, involving 80 adults, investigated ketamine's effect on the stress hormone system as a potential indicator of its rapid antidepressant effects, particularly in reducing suicidal ideation.
📈 Participants receiving ketamine showed a rise in normalized waking cortisol from an average of 0.42 to 0.80 post-treatment, while the control group (midazolam) saw a slight decrease.
💡 While the cortisol increase at 24 hours post-treatment coincided with reduced suicidal thoughts, the correlation was small to medium and not statistically significant, indicating a need for further research into the underlying mechanisms.
#Ketamine #MentalHealth #ClinicalTrial
🧠 The research, involving 80 adults, investigated ketamine's effect on the stress hormone system as a potential indicator of its rapid antidepressant effects, particularly in reducing suicidal ideation.
📈 Participants receiving ketamine showed a rise in normalized waking cortisol from an average of 0.42 to 0.80 post-treatment, while the control group (midazolam) saw a slight decrease.
💡 While the cortisol increase at 24 hours post-treatment coincided with reduced suicidal thoughts, the correlation was small to medium and not statistically significant, indicating a need for further research into the underlying mechanisms.
#Ketamine #MentalHealth #ClinicalTrial
Molecular snapshots confirm ketamine’s opioid nature
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#Ketamine #OpioidNature #MolecularSnapshots
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#Ketamine #OpioidNature #MolecularSnapshots
Nature
Molecular snapshots confirm ketamine’s opioid nature
Nature Structural & Molecular Biology - The therapeutic and reinforcing mechanisms of ketamine have been historically attributed to NMDAR (N-methyl-d-aspartate receptor) antagonism. A study now...