Microglia-mediated inflammation and synaptic pruning contribute to sleep deprivation-induced mania in a sex-specific manner 🧠💤⚡️🌀
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#Microglia #SleepDeprivation #Mania #Neuroscience #Inflammation
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#Microglia #SleepDeprivation #Mania #Neuroscience #Inflammation
Nature
Microglia-mediated inflammation and synaptic pruning contribute to sleep deprivation-induced mania in a sex-specific manner
Translational Psychiatry - Microglia-mediated inflammation and synaptic pruning contribute to sleep deprivation-induced mania in a sex-specific manner
Inflammation leads to lower reward motivation by causing microglia to remove glutamate inputs from dopamine neurons in the brain’s reward center 🧠✨🛑
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#Inflammation #RewardSystem #Dopamine #Neuroscience #Microglia
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#Inflammation #RewardSystem #Dopamine #Neuroscience #Microglia
It is not amyloid plaques that cause sleep loss in Alzheimer’s disease but microglia. The appearance of plaques cost Alzheimer’s mice 1.5-2 hours of sleep per night. Microglia-blocking drugs gave the Alzheimer’s mice an extra two hours of sleep per night, extending restorative sleep periods.
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#Alzheimers #SleepScience #Microglia
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#Alzheimers #SleepScience #Microglia
ScienceAlert
It's Not Amyloid Plaques Stealing Sleep in Alzheimer's – It's Immune Cells
Breaking the feedback loop.
Preclinical study identifies TAB2 as a key regulator of microglial neuroinflammation in Parkinson's disease models
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#ParkinsonsDisease #Microglia #Neuroinflammation
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#ParkinsonsDisease #Microglia #Neuroinflammation
The Advanced Portfolio
TAB2 Causes Neuronal Damage by Aggravating Microglia‐Mediated Neuroinflammation in Parkinson's Disease
In microglia, STAT3 upregulates TAB2, which promotes NF-κB activation through its NZF domain-mediated recognition of K63-linked ubiquitin chains, leading to inflammatory cytokine release and subseque...