In World Trade Center responders, PTSD with cognitive impairment is linked to cortisol-induced neural toxicity and ROS-related apoptotic pathways. The results suggest that chronic cortisol dysregulation may drive accelerated brain aging and cognitive decline.
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#WTCResponders #PTSD #CortisolCognition #BrainAging #NeuralToxicity
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#WTCResponders #PTSD #CortisolCognition #BrainAging #NeuralToxicity
SpringerLink
Mechanistic signatures of comorbid PTSD with cognitive impairment implicate cortisol-induced neural toxicity
Neuropsychopharmacology - Mechanistic signatures of comorbid PTSD with cognitive impairment implicate cortisol-induced neural toxicity