PSEUDOTHROMBOCYTOPENIA .
Pseudothrombocytopenia is mediated by EDTA-dependent antibodies that react with platelets in blood that is anticoagulated with EDTA (chelates calcium, necessary for clotting reactions), causing platelet clumping and falsely low platelet counts.
Diagnostic criteria for pseudothrombocytopenia:
a. Absence of clinical bleeding
b. Automated platelet count <150 × 109 /L
c. Platelet clumps on smear
d. Normal platelet count using a different anticoagulant (typically sodium citrate, but whatever works!)
Pseudothrombocytopenia is mediated by EDTA-dependent antibodies that react with platelets in blood that is anticoagulated with EDTA (chelates calcium, necessary for clotting reactions), causing platelet clumping and falsely low platelet counts.
Diagnostic criteria for pseudothrombocytopenia:
a. Absence of clinical bleeding
b. Automated platelet count <150 × 109 /L
c. Platelet clumps on smear
d. Normal platelet count using a different anticoagulant (typically sodium citrate, but whatever works!)
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