ITP approach.
Petechiae are pinpoint hemorrhages <2 mm in size, purpura are 2 mm to 1 cm, and ecchymoses are >1 cm.
patient has all three. These lesions are the result of extravasation of blood from the vasculature into skin/mucosa and do not blanch.
platelet disorder could explain these symptoms and physical findings.
But is the platelet issue qualitative (platelets are normal in number but abnormal in function) or quantitative (platelets are normal in function, but abnormal in number)?.
There's a test for that.
Immature platelets = newly released platelets.
The immature platelet fraction If low/normal, there is decreased platelet production; if elevated, there is increased platelet destruction.
The elevated immature platelet fraction tells us we are dealing with a process causing platelet destruction.
The degree of thrombocytopenia narrows our differential to TMA and ITP. The absence of concomitant hemolytic anemia points us to the right diagnosis:
Petechiae are pinpoint hemorrhages <2 mm in size, purpura are 2 mm to 1 cm, and ecchymoses are >1 cm.
patient has all three. These lesions are the result of extravasation of blood from the vasculature into skin/mucosa and do not blanch.
platelet disorder could explain these symptoms and physical findings.
But is the platelet issue qualitative (platelets are normal in number but abnormal in function) or quantitative (platelets are normal in function, but abnormal in number)?.
There's a test for that.
Immature platelets = newly released platelets.
The immature platelet fraction If low/normal, there is decreased platelet production; if elevated, there is increased platelet destruction.
The elevated immature platelet fraction tells us we are dealing with a process causing platelet destruction.
The degree of thrombocytopenia narrows our differential to TMA and ITP. The absence of concomitant hemolytic anemia points us to the right diagnosis:
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