Diagnosis and Management of Kawasaki Disease.
1.IVIG prevents the development of coronary aneurysms in a dose-dependent fashion. A single dose of 2 g per kg is administered within 10 days of illness.
2.high-dose aspirin, 80 to 100 mg per kg per day in four divided doses, until the patient is afebrile for 48 to 72 hours (some recommend continuing until the 14th day of illness has also passed). Afterward, low-dose aspirin at 3 to 5 mg per kg per day is given as a single dose until six to eight weeks after disease onset.
3.Approximately 10% of patients have refractory disease that does not respond to initial therapy (i.e., fever persists or recurs 36 hours after initial IVIG dose). These patients usually receive a second infusion of IVIG at 2 g per kg. The AHA guideline states that the relative roles of repeated use of IVIG and other adjunctive therapies (e.g., corticosteroids, TNF-α antagonists, plasma exchange, cyclophosphamide).
1.IVIG prevents the development of coronary aneurysms in a dose-dependent fashion. A single dose of 2 g per kg is administered within 10 days of illness.
2.high-dose aspirin, 80 to 100 mg per kg per day in four divided doses, until the patient is afebrile for 48 to 72 hours (some recommend continuing until the 14th day of illness has also passed). Afterward, low-dose aspirin at 3 to 5 mg per kg per day is given as a single dose until six to eight weeks after disease onset.
3.Approximately 10% of patients have refractory disease that does not respond to initial therapy (i.e., fever persists or recurs 36 hours after initial IVIG dose). These patients usually receive a second infusion of IVIG at 2 g per kg. The AHA guideline states that the relative roles of repeated use of IVIG and other adjunctive therapies (e.g., corticosteroids, TNF-α antagonists, plasma exchange, cyclophosphamide).
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