5οΈβ£ Shared role in erythropoiesis and DNA synthesis
Inside bone marrow, folate and B12 cooperate to generate tetrahydrofolate, a cofactor for DNA and red cell production. Without them, cells enlarge without dividing properly, producing megaloblastic anemia.
π’ Example: B12 deficiency traps folate in its inactive form (βmethyl-folate trapβ), halting DNA replication and leading to fatigue, pale skin, and neurological symptoms.
Inside bone marrow, folate and B12 cooperate to generate tetrahydrofolate, a cofactor for DNA and red cell production. Without them, cells enlarge without dividing properly, producing megaloblastic anemia.
π’ Example: B12 deficiency traps folate in its inactive form (βmethyl-folate trapβ), halting DNA replication and leading to fatigue, pale skin, and neurological symptoms.
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