Lets Learn Bio-IT School ๐Ÿ‡ซ๐Ÿ‡ท๐Ÿ‡ฎ๐Ÿ‡ณ
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We provide every possible information's to bring the Biologists and Bioinformaticians together under one roof.

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We are excited to be co-hosting LabGenius with Imperial College Synthetic Biology Society for our second event of the Winter term. Harry Rickerby will be discussing the company's latest work in protein engineering and drug discovery, with a Q&A section at the end. We look forward to seeing you there!

Abstract: LabGenius is a startup that lives at the interface between synthetic biology, computational biology and data science. In this talk, I will give you an insight into the problems we are solving in protein engineering and drug discovery, and how weโ€™re going about solving them.

Apply here :
https://fb.me/e/27GzReU1G

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Postdoc position available with Berger_labs, BrisBioDesign Using structural biology protein engineering and display technology to generate high-affinity nano-bodies as anti-venom for snake toxins

Calendar Apply by 6th Oct

Check here for more info

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ADVANCED COURSE 
Biocatalysis and Protein Engineering

This Advanced Course is aimed at professionals (MSc, PhD or equivalent experience) in biochemical engineering, organic chemistry, fermentation technology, biochemistry or microbiology with a basic working knowledge of the other disciplines.

The course is primarily aimed at those already employed in industry who wish to up-date their theoretical knowledge and practical insight in this field.

๐Ÿ“šRead the complete brochure here

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18-month Post-Doctoral position in enzyme-based catalysis - TBI - Toulouse Biotechnology Institute, Bio & Chemical Engineering

18 months length.
As early as the 1st June 2022.

๐ŸŒFor more information or to apply, please contact regis.faure@insa-toulouse.fr

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Third Hands-on Computational Enzyme Design/protein engineering Course

๐Ÿ—“Taking place ONLINE on 30 May - 1 June, 2022.

This interactive course will cover most of the tools developed at the Loschmidt Laboratories. Experimentalists are welcome!

๐ŸŒYou can find all the details at the link: https://loschmidt.chemi.muni.cz/academy/

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#latest #science #bioinfo #proteinengineering #ai

AI-engineered enzyme eats entire plastic containers

Six years ago scientists sifting through debris of a plastic bottle recycling plant discovered a bacterium that can degrade PET. The organism has two enzymes that hydrolyse the polymer first into mono-(2-hydroxyethyl) terephthalate and then into ethylene glycol and terephthalic acid to use as an energy source.

One enzyme in particular, PETase, has become the target of protein engineering efforts to make it stable at higher temperatures and boost its catalytic activity.

A neural network helped the team decide how to modify the protein scaffold. The algorithm was first trained on 19,000 proteins of similar size, though of very different functionalities. For each of PETaseโ€™s 290 amino acids, the program checked whether it fits well within its immediate structural environment compared with other proteins

๐Ÿ“šRead the full article

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Offline Workshop 
โ€œAdvances in Protein Design: From Therapeutic Proteins to Synthetic Biologyโ€.

This meeting will bring together leading experts in protein design to discuss synergistic combinations of computational methodology and experimental directed evolution, and their applications in synthetic biology, materials science, bioelectronics, biotechnology, food technology, vaccine development, and drug design.

๐Ÿ“Four days event in the scenic Hula Valley in northern Israel.

๐Ÿ“šThe topics to be covered are:
- Deep learning approaches and other new methods in computational design
- Applications of deep mutational scanning
- Proteins with unnatural amino acids
- The design of protein-cofactor complexes
- Protein therapeutics
- Design and engineering of enzymes with novel functions
- Membrane protein design
- Building blocks for synthetic biology

๐ŸŒFor more info
https://www.isfproteindesign.com/

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#news #bioinformatics #proteomics #proteinengineering

There are numerous applications for engineering proteins and enzymes to have the desired functioning in molecular biology, biotechnology, biomedical sciences, health, and medicine. For enzyme engineering campaigns using directed evolution and rational design, the size of the protein sequence space and all the potential proteins it contains can be a significant barrier.

๐Ÿ‘จ๐Ÿฝโ€๐Ÿ”ฌ Mehdi D. Davari, Frederic Cadet, and Marcel Wittmund, as reviewed on
"Learning Epistasis and Residue Coevolution Patterns: Current Trends and Future Perspectives for Advancing Enzyme Engineering"

๐Ÿ“šRead the article in detail
https://tinyurl.com/3d54ueyn

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๐Ÿš€ PPIformer, a game-changing ML model for engineering protein-protein interactions. A collaborative effort by experts from the Czech Institute of Informatics, Loschmidt Laboratories, Masaryk University, and IOCB Prague.

๐Ÿ‘‰How can machine learning elevate protein therapeutics?

๐Ÿ“‘Explore the latest preprint, 'Learning to design protein-protein interactions with enhanced generalization': https://arxiv.org/abs/2310.18515.

#ProteinEngineering #MachineLearning #Bioinformatics

๐Ÿ“ฒ Join the Nyberman community at
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๐Ÿ“ข Using Residue Interaction Networks to understand protein function and evolution and to engineer new proteins

Residue Interaction Networks (RINs) are a powerful tool for protein analysis

- RINs offer a graph-based representation of protein structures.
- RINs are computationally efficient and have been widely used to explore protein stability, function, and allostery.
- RINs have been successfully applied in protein folding, stability, and interaction studies, offering a framework for creating designer proteins.

The paper highlights various tools available for RIN analysis, which handle different types of interactions and inputs, such as crystal structures, simulation data, and protein comparisons.

Learn More

#ResourcePost #RIN #ProteinEngineering


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