A ganglioside-based immune checkpoint enables senescent cells to evade immunosurveillance during aging

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#Immunology #AgingResearch #CellSenescence #CancerImmunotherapy #Gangliosides

Physical training reduces cell senescence and associated insulin resistance in skeletal muscle 💪🧬🏋️‍♂️

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#PhysicalFitness #CellSenescence #InsulinResistance #SkeletalMuscle #HealthBenefits

🔬 Cellular Senescence: A Complex Relationship with Stemness

Cellular senescence, a state of stable cell cycle arrest, was traditionally viewed as the opposite of stem cell renewal. However, new research reveals a "gray zone" where senescence may actually promote stemness, depending on the cell type and biological context.

Senescence, triggered by various stressors, results in unique cell characteristics including altered morphology, a specific secretome (SASP), and metabolic changes. While transient senescence aids in tissue repair and homeostasis, its prolonged presence is linked to chronic inflammation and age-related diseases.

Stem cells are critical for tissue regeneration, possessing the ability to self-renew and differentiate. Different types of stem cells exist, from embryonic to adult multipotent stem cells, and induced pluripotent stem cells (iPSCs) can be generated from somatic cells.

Evidence shows both antagonistic and synergistic interplay between senescence and stemness. While antagonism can hinder tissue regeneration, synergy is often observed in tumorigenesis, where senescence may mask or even promote cancer stemness, contributing to tumor aggressiveness and therapy resistance.

#CellSenescence #StemCells #BiomedicalResearch