A new study in mice shows females sleep less, wake up more often and get less restorative sleep than males | The findings reveal the underlie sleep differences in men and women and could have broad implications for biomedical research, which for decades has focused primarily on males.

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#SleepResearch #GenderDifferences #HealthScience #BiomedicalResearch #MiceStudy

Scientists engineer substrates hostile to bacteria but friendly to cells | Nanostructured anodic alumina surfaces can be used to culture cells and tissue

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#Biotechnology #CellCulture #Nanotechnology #BiomedicalResearch #TissueEngineering

Science has a reproducibility crisis on its hands, and biomedical researchers believe the infamous “publish or perish” research culture is behind it. Over 70% could not reproduce another scientist’s experiment. More than 62% attributed irreproducibility in science to “publish or perish” culture.

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#ReproducibilityCrisis #PublishOrPerish #ScienceChallenges #BiomedicalResearch #ResearchIntegrity

Researchers create gel that can self-heal like human skin | The hydrogel has a unique structure, making it the first to combine strength and flexibility with self-healing capabilities.

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#SelfHealingGel #HydrogelInnovation #SmartMaterials #BiomedicalResearch #FutureOfMedicine

Lining medical stents with cilia could fend off infections 🦠 — When exposed to ultrasound waves 🔊, the cilia can wiggle and flush out substances that are stuck to the devices inside patients' bodies 🏥.

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#MedicalInnovation #StentTechnology #InfectionPrevention #UltrasoundTherapy #BiomedicalResearch

Soluble N-terminal region of prion protein causes rapid neurodegeneration in prion disease 🧬🧠⚠️ - Science Advances

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#PrionDisease #Neurodegeneration #ScienceAdvances #BiomedicalResearch #ProteinStudy

Decoding the sources of human facial shape variability and craniofacial syndromes: « How positional programs in embryonic mesenchyme shape the individual human face 🧑‍🦰 – and open new paths to understanding craniofacial disorders 🦷. »

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#FacialShapeVariability #CraniofacialSyndromes #EmbryonicDevelopment #BiomedicalResearch #HumanAnatomy

Researchers at UQ’s Queensland Brain Institute (QBI) and the School of Biomedical Sciences have discovered a nanoscale molecular scaffold that exists in the tissue that surrounds the axon that protects sensory axons from degenerating. 🧠🔬✨

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#QBI #BiomedicalResearch #Neuroscience #AxonHealth #MolecularScaffold

🔬 Cellular Senescence: A Complex Relationship with Stemness

Cellular senescence, a state of stable cell cycle arrest, was traditionally viewed as the opposite of stem cell renewal. However, new research reveals a "gray zone" where senescence may actually promote stemness, depending on the cell type and biological context.

Senescence, triggered by various stressors, results in unique cell characteristics including altered morphology, a specific secretome (SASP), and metabolic changes. While transient senescence aids in tissue repair and homeostasis, its prolonged presence is linked to chronic inflammation and age-related diseases.

Stem cells are critical for tissue regeneration, possessing the ability to self-renew and differentiate. Different types of stem cells exist, from embryonic to adult multipotent stem cells, and induced pluripotent stem cells (iPSCs) can be generated from somatic cells.

Evidence shows both antagonistic and synergistic interplay between senescence and stemness. While antagonism can hinder tissue regeneration, synergy is often observed in tumorigenesis, where senescence may mask or even promote cancer stemness, contributing to tumor aggressiveness and therapy resistance.

#CellSenescence #StemCells #BiomedicalResearch

A Drug Commonly Used to Treat Erectile Dysfunction, May Also Help Regenerate Damaged Muscle. Research Suggests the Medication, Tadalafil Could Support Muscle Repair and Recovery by Influencing Biological Processes Involved in Muscle Regeneration in Mouse Models.

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#Tadalafil #MuscleRegeneration #BiomedicalResearch