"Suspended animation" drug could buy time in medical emergencies | Donepezil, a widely used drug could be repurposed to slow down organ damage and save lives by giving patients more time to reach a hospital. Tested in tadpoles, DNP slowed oxygen consumption, heart rate and swimming motion.

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#SuspendedAnimation #MedicalEmergencies #DrugRepurposing #OrganDamage #SaveLives

Exciting Breakthrough: Repurposing an FDA-Approved Drug to Target Cancer Stem Cells in Breast Cancer

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#CancerResearch #BreastCancer #DrugRepurposing #StemCellTherapy #MedicalInnovation

Review of multitude of preclinical and clinical studies support the repurposing of atomoxetine for Alzheimer's Disease (AD) drug development for both symptoms and neuroprotection to slow disease progression 🧠💊📈

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#AlzheimersResearch #Atomoxetine #DrugRepurposing #Neuroprotection #ClinicalTrials

Scientists find a new potential treatment for Alzheimer’s using a formerly discovered blood cancer treatment.

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#AlzheimersResearch #DrugRepurposing #BloodCancerTherapy #NeuroscienceBreakthrough #AlzheimersTreatment

Common anti-seizure drug prevents Alzheimer’s plaques from forming in mouse models, human neurons and brains of Down syndrome patients, who are at high risk of an aggressive form of Alzheimer’s. FDA-approved drug restored neuronal function, steering neurons away from producing toxic amyloid‑beta.

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#Alzheimers #DownSyndrome #AmyloidBeta #NeuronalFunction #DrugRepurposing

🧠 Researchers from Lund University have identified pramipexole, an existing Parkinson's disease drug, as a potential new add-on therapy for depression characterized by anhedonia (reduced ability to feel joy/pleasure).

🔬 In a randomized, double-blind, placebo-controlled trial of 82 participants, pramipexole showed a more pronounced improvement in anhedonia symptoms compared to placebo after nine weeks, with effects maintained during a six-month follow-up.

💡 Advanced brain imaging suggests pramipexole positively impacts the brain's reward system and increases physical activity, potentially by affecting the dopamine system.

✅ The study, published in Nature Medicine, found the treatment generally safe and well-tolerated, with efficacy and safety maintained over the six-month follow-up.

#DepressionResearch #Anhedonia #DrugRepurposing

Aging-related genes can be used to find existing drugs that could increase longevity or accelerate aging, researchers find

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#Longevity #AgingResearch #DrugRepurposing

🔬 Northeastern University researchers have developed a method to identify existing drugs that could be repurposed to affect aging.

🔬 By mapping aging-related genes to specific networks, scientists can now target drugs that may reverse or speed up aging processes.

🔬 The study identified 370 drugs with potential to affect aging hallmarks, with 14 showing promise for longevity and 14 others potentially accelerating aging.

🔬 One identified candidate drug is oxymetazoline, commonly found in nasal sprays, which researchers predict could improve cell-cell communication.

#Longevity #AgingResearch #DrugRepurposing

🧠 A common antidepressant, vortioxetine, has shown unexpected effectiveness in lab tests against glioblastoma, a severe brain tumor with a poor prognosis.

🔬 Researchers tested existing drugs that can cross the blood-brain barrier, finding vortioxetine to be the most effective antidepressant against cancer cells.

mice studies indicate vortioxetine shows promise when combined with standard treatments, and clinical trials are planned.

#BrainTumor #CancerResearch #DrugRepurposing