Scientists unveil more than 600 new tissue models of human cancer: « Derived from patient tumor samples and available to researchers around the world, the cells will aid the development of new cancer treatments. »

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#CancerResearch #TumorModels #CancerTreatmentDevelopment

🔬 Nearly 700 new cancer models, derived from patient tumors representing 25 cancer types, have been developed by an international research team.

🔬 These models, primarily organoids (3D cell cultures), mimic the genetic and molecular traits of original tumors and are now available to researchers globally.

🔬 The initiative, a 10-year project funded by the National Cancer Institute and the UK's Wellcome Trust, involved over two dozen institutions and aimed to significantly expand the availability of patient-derived cancer models.

🔬 Researchers analyzed over 2,700 tumor samples from patients in the US, UK, and Netherlands, successfully converting about one-third into long-lasting lab models.

#CancerResearch #DrugDevelopment #Oncology

🧠 Scientists have uncovered a mechanism gliomas use to exploit brain functions for growth.

🔬 A protein called neuroligin-3 (NLGN3) binds to CSPG4 on glioma cells, tightening the cell membrane and activating PIEZO1, a channel that signals for cell proliferation.

🐭 Glioma cells lacking PIEZO1 showed significantly less proliferation in mice, suggesting PIEZO1 is crucial for their growth.

💡 This mechanism is also present in healthy brain cells (OPCs), where it helps maintain a reserve of immature cells. Glioma cells appear to hijack this normal process.

#BrainCancer #Glioma #CancerResearch

✈️ A study published August 17 in JAMA Internal Medicine found that flight attendants and pilots have the highest proportions of radiation-related cancer deaths among over 500 U.S. occupations.

🔬 The research, using data from 2020-2024 covering nearly 13 million deaths, revealed that 6.9% of flight attendant deaths and 6.7% of pilot deaths were from radiation-related cancers, significantly higher than other professions.

🩺 The findings support considering occupational radiation protections for U.S. aircrew, who receive higher annual radiation doses due to cosmic radiation at high altitudes compared to the general population.

#AviationHealth #OccupationalSafety #CancerResearch

Babies born under sugar rationing grew into adults with lower cancer risk

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#CancerResearch #NutritionScience #PublicHealth

Jellyfish enable surprising new findings about cancer: « Although increased cell proliferation is a hallmark of cancerous tissues, in some cases, it may actually be protective against tumor growth. »

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#CancerResearch #JellyfishBiology #TumorGrowthInsights

🔬 Caltech study challenges cancer paradigm: High cell proliferation may be protective against tumor growth by enabling "proofreading" to destroy potentially cancerous cells.

🔬 Mathematical models and experiments with cancer-resistant jellyfish (Aurelia aurita) suggest that rapid cell turnover can act as a quality control mechanism.

🔬 Disrupting cell proliferation or cell death in jellyfish exposed to carcinogens led to abnormal growths, supporting the idea that proliferation is key to preventing neoplasia.

🔬 The findings, published August 18 in PNAS, propose a new cancer prevention strategy focusing on enhancing the body's natural proofreading system.

#CancerResearch #CellBiology #HealthTech

Nitrate and nitrite intake and risk of colorectal cancer: a population-based cohort study | JNCI: Journal of the National Cancer Institute | Oxford Academic

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#ColorectalCancer #NitrateNitrite #CancerResearch

mRNA immunotherapy eliminates pancreatic tumors in mice: Approximately 50% of mice with pancreatic cancer treated with the mRNA immunotherapeutic cocktail saw complete tumor responses and more impressively, remained disease free for a year, even after treatment had been stopped.

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#mRNAImmunotherapy #PancreaticCancer #CancerResearch breakthroughs should be one word per hashtag; but instruction says format with # and separate with spaces. Ensure exactly three hashtags, no extra text. Use common tags: #mRNA, #Immunotherapy, #PancreaticCancer? They want high-traffic. Use #mRNA #Immunotherapy #PancreaticCancer? But they require hashtags with #. Should be readable: #mRNAImmunotherapy #PancreaticCancer #CancerResearch. But 3. Let's pick: #mRNAImmunotherapy #PancreaticCancer #CancerResearch

* ⬆️ Alcohol-linked cancer deaths in the U.S. have doubled from approximately 11,400 in 1990 to over 23,100 in 2023.

* 🔬 A Sylvester Comprehensive Cancer Center study, presented at ASCO 2025 and published in The Lancet Regional Health—Americas, reveals alcohol's impact extends beyond liver cancer to include colorectal, breast, esophageal, and pancreatic cancers.

* 🎗️ Researchers emphasize alcohol as a changeable risk factor for cancer, with increased mortality rates noted in men and adults aged 55 and older, though rises were observed across most demographics and cancer types.

#CancerResearch #PublicHealth #AlcoholAwareness

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Cancer cells release antioxidants to prevent immune cells from destroying them

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#CancerResearch #Immunotherapy #Antioxidants

🔬 Scientists discovered that cancer cells release natural antioxidants (like PRDX1) to deactivate immune cells (T cells) that are supposed to destroy them.

🔬 T cells actually need reactive oxygen species (molecules that were previously thought to be damaging) to activate and fight cancer. Tumors exploit this by releasing antioxidants to "smother" T cells.

🔬 In lab studies using mice, blocking cancer cells' ability to produce these antioxidants made them more responsive to existing cancer immunotherapies.

🔬 This new understanding could lead to ways to improve cancer immunotherapies, potentially by using "pro-oxidants" to boost T cell activity, rather than antioxidants, which might inadvertently harm the immune response.

#CancerResearch #Immunotherapy #MedicalBreakthrough

In a US trial, teclistamab wiped out cancer completely in 78% of high risk myeloma patients, against 0% on standard treatment, and cut two year progression to 8%.

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#MultipleMyeloma #CancerResearch #ClinicalTrial

Simpler clinical trials can safely fast-track new treatments for severe bladder cancer. For patients too weak to have their bladder removed, experts agree these streamlined studies are an ethical alternative to traditional randomized testing

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#BladderCancer #ClinicalTrials #CancerResearch

✨ Cancer Breakthrough: CAR T-Cell Therapy Shows Promise Against Solid Tumors
A 3-year-old boy with advanced liver cancer (hepatoblastoma) achieved complete remission with an experimental CAR T-cell therapy, a significant step as this treatment has historically been limited to blood cancers. The therapy genetically engineers a patient's immune cells to fight cancer.

🔬 Personalized Treatment Targets Rare Cancer
The boy, whose cancer had spread to his lungs and potentially bones, received two doses of GPC3-CAR T-cell therapy, an experimental treatment designed to recognize a protein common in liver cancers. This approach, detailed in The New England Journal of Medicine, is showing potentially life-saving results for solid tumors, even in a chemotherapy-resistant case.

🌟 Hope for Durable Remission
After receiving the CAR T-cell infusions, the boy showed a partial response and, eight weeks later, follow-up scans revealed no remaining signs of disease except for scarring. He remained disease-free 12 months later, demonstrating the potential for durable responses outside of traditional chemotherapy.

#CancerResearch #Immunotherapy #CARtCell

🔬 Scientists have engineered probiotic bacteria (E. coli Nissle 1917) to act as tiny drug factories within tumors, producing chemotherapy while stimulating the immune system.

🔬 In tests on mice with colorectal tumors, this approach led to complete regression in 3 out of 7 tumors (43%), showing promise in targeting cancer cells while potentially reducing systemic side effects.

🔬 The engineered bacteria were programmed to deliver a triple-whammy: producing chemotherapy (5-FU) directly in the tumor, acting as an immune stimulant, and blocking a tumor's immune-suppressing mechanism.

#CancerResearch #Probiotics #Immunotherapy

🩸 First papers from the large-scale NHS cancer blood test trial, involving 142,000 volunteers aged 50–77, have been published in leading journals, assessing the Galleri® multi-cancer early detection (MCED) test.

📄 One paper in the New England Journal of Medicine shows fewer people diagnosed with stage 4 cancers in the test group, with more early-stage diagnoses and fewer emergency diagnoses, but no overall difference in late-stage cancers (stages 3 & 4 combined) compared to the control group.

🔬 The second paper in Nature Medicine reports the Galleri® test's accuracy: around one-third of cancer patients received a positive signal, while less than 0.5% of those without cancer had a false positive result.

#CancerResearch #NHS #EarlyDetection

🔬 MIT biologists have identified a cellular pathway (controlled by YAP1) crucial for colorectal cancer spreading to other organs, particularly the liver.

🍎 This pathway, normally used for tissue repair, can be activated by a high-fat diet through the production of fatty molecules called ceramides, enabling cancer cells to grow and migrate.

💊 Blocking ceramide production with drugs could be a new strategy to prevent metastasis in colon cancer patients, as blocking YAP1 or ceramide enzymes significantly reduced spread in mouse studies.

#CancerResearch #Metastasis #MedicalBreakthrough

📈 Cancer Cases Surge in Under-50s: Major research in England reveals significant increases in early-onset prostate, bowel, kidney, and uterine cancers. Prostate cancer diagnoses quadrupled since 2001, while bowel, kidney, and uterine cases more than doubled.

🌍 Global Trend with Local Impact: Similar "significant increases" in early-onset cancers were identified in the US and Netherlands for certain types, though lung cancer declined in all three countries, linked to reduced smoking.

💡 Lifestyle Factors Key: Experts point to the global obesity epidemic, poor diets, and insufficient exercise as major contributors, alongside increased awareness and earlier diagnosis. About 40% of cancers are linked to modifiable risks.

🔬 Research and Prevention Focus: New trials and government initiatives are underway in England to investigate the rise in early-onset cancers, particularly bowel cancer, and to improve early diagnosis and prevention strategies.

#CancerResearch #PublicHealth #EarlyDetection

🦠 A major study suggests the bacterium H. pylori, known for causing stomach ulcers and gastric cancer, may be linked to approximately 22% of colorectal cancer cases globally.

📈 This research analyzed data from 43 international studies with nearly 48.7 million participants. It found a 1.59-fold increased risk of colorectal cancer in those exposed to H. pylori.

🌍 The Western Pacific region, including China, Mongolia, and Vietnam, showed the highest estimated proportion (around 25%) of colorectal cancer cases linked to H. pylori.

🏥 Existing H. pylori screening and eradication programs for gastric cancer could potentially offer a dual benefit by also reducing colorectal cancer risk, particularly in regions with high infection rates.

#CancerResearch #PublicHealth #H pylori