Mouse study shows that anti-anxiety and hallucinogenic effects of a psychedelic drug work through different neural circuits. This suggests it may be possible to make psychiatric drugs based on psychedelics, but without hallucinatory side effects.
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#Psychedelics #MentalHealth #Neuroscience #AnxietyRelief #DrugDevelopment
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#Psychedelics #MentalHealth #Neuroscience #AnxietyRelief #DrugDevelopment
UC Davis
Anti-Anxiety and Hallucination-Like Effects of Psychedelics Mediated by Distinct Neural Circuits
New research suggests that it could be possible to separate treatment from hallucinations when developing new drugs based on psychedelics. The anti-anxiety andhallucination-inducing qualities of psychedelic drugs work through different neural circuits, according…
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Deadly Aspergillus fungal strains, with mortality rates ranging between 30% to 90%, 5 times more likely to acquire resistance to new drugs due to continued use of an agricultural fungicide called ipflufenoquin, which has the same biological target and kills fungi in the same way as antifungal drugs.
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#AspergillusAwareness #FungalResistance #PublicHealth #AgriculturalImpact #DrugDevelopment
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#AspergillusAwareness #FungalResistance #PublicHealth #AgriculturalImpact #DrugDevelopment
Technology Networks
Strains of <i>Aspergillus fumigatus</i> Five Times More Likely To Acquire Resistance to Antifungals
Researchers have identified strains of one of the world's most dangerous pathogens that are five times more likely to acquire antifungal resistance.
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The world’s largest study of the genetics of osteoarthritis has identified more than 500 previously unknown genetic links to the disease, and hundreds of potential new drug targets that could fast track the development of more effective treatments. 🧬💊🦴✨
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#OsteoarthritisResearch #GeneticStudy #HealthInnovation #DrugDevelopment #MedicalBreakthroughs
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#OsteoarthritisResearch #GeneticStudy #HealthInnovation #DrugDevelopment #MedicalBreakthroughs
Helmholtz Munich
Helmholtz Munich, is a member of the Helmholtz Association of German Research Centres
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Researchers resurrect extinct gene in plants 🌱 with major implications for drug development 💊, including cancer treatments 🎗️ and antibiotics 💉.
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#GeneResurrection #PlantResearch #DrugDevelopment #CancerTreatment #Biotechnology
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#GeneResurrection #PlantResearch #DrugDevelopment #CancerTreatment #Biotechnology
Northeastern Global News
Researchers resurrect extinct gene in plants with major implications for drug development
By reviving a defunct gene in tobacco plants, researchers uncovered a new kind of peptide, or mini protein, for use in drug development.
Comparative analyses for plant virus-based cancer immunotherapy drug development 🌱🦠 - Plant virus triggers immune response that targets and destroys cancer cells 💪🏽🎗️
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#PlantVirus #CancerImmunotherapy #DrugDevelopment #ImmuneResponse #CancerResearch
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#PlantVirus #CancerImmunotherapy #DrugDevelopment #ImmuneResponse #CancerResearch
Cell Biomaterials
Comparative analyses for plant virus-based cancer immunotherapy drug development
Cowpea mosaic virus (CPMV) is a plant virus that has been repurposed as an intratumoral
immunotherapy agent. Its anti-tumor efficacy is unique when compared with other plant
viruses. The focus of this work is to identify the key determinants that set CPMV…
immunotherapy agent. Its anti-tumor efficacy is unique when compared with other plant
viruses. The focus of this work is to identify the key determinants that set CPMV…
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Scientists reengineered the chemotherapy drug 5-fluorouracil into a spherical nucleic acid that entered leukemia cells 12.5× more efficiently, killed them 20,000× more effectively, and slowed cancer progression 59× in mice—marking a major preclinical advance in chemotherapy design. 🧪💊🐭✨
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#CancerResearch #Chemotherapy #Leukemia #MedicalInnovation #DrugDevelopment
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#CancerResearch #Chemotherapy #Leukemia #MedicalInnovation #DrugDevelopment
ACS Publications
Chemotherapeutic Spherical Nucleic Acids
Herein, we describe experiments showing that liposomal spherical nucleic acid (SNA) constructs comprised of 5-fluorouracil (5-Fu) are selectively taken up by myeloid cells, including acute myeloid leukemia (AML) cells, and act as chemotherapeutics. Specifically…
Science News
Scientists unveil more than 600 new tissue models of human cancer: « Derived from patient tumor samples and available to researchers around the world, the cells will aid the development of new cancer treatments. » Read Full Article #CancerResearch #TumorModels…
🔬 Nearly 700 new cancer models, derived from patient tumors representing 25 cancer types, have been developed by an international research team.
🔬 These models, primarily organoids (3D cell cultures), mimic the genetic and molecular traits of original tumors and are now available to researchers globally.
🔬 The initiative, a 10-year project funded by the National Cancer Institute and the UK's Wellcome Trust, involved over two dozen institutions and aimed to significantly expand the availability of patient-derived cancer models.
🔬 Researchers analyzed over 2,700 tumor samples from patients in the US, UK, and Netherlands, successfully converting about one-third into long-lasting lab models.
#CancerResearch #DrugDevelopment #Oncology
🔬 These models, primarily organoids (3D cell cultures), mimic the genetic and molecular traits of original tumors and are now available to researchers globally.
🔬 The initiative, a 10-year project funded by the National Cancer Institute and the UK's Wellcome Trust, involved over two dozen institutions and aimed to significantly expand the availability of patient-derived cancer models.
🔬 Researchers analyzed over 2,700 tumor samples from patients in the US, UK, and Netherlands, successfully converting about one-third into long-lasting lab models.
#CancerResearch #DrugDevelopment #Oncology
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A US study of 1,981 FDA-approved drugs found the average number of patents per drug rose from 2.1 in 1990 to 6.9 in 2019, extending market exclusivity by six years on average.
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#PharmaPatents #DrugDevelopment #MarketExclusivity
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#PharmaPatents #DrugDevelopment #MarketExclusivity
Jamanetwork
Patents on Small-Molecule Drugs Approved by the US Food and Drug Administration, 1990-2019
This study characterizes the evolution of patent portfolios on all small-molecule drugs approved by the FDA from 1990 to 2019 and applied a range of measures to understand how these portfolios may be affecting generic competition.