Scientists reengineered the chemotherapy drug 5-fluorouracil into a spherical nucleic acid that entered leukemia cells 12.5× more efficiently, killed them 20,000× more effectively, and slowed cancer progression 59× in mice—marking a major preclinical advance in chemotherapy design. 🧪💊🐭✨
Read Full Article
#CancerResearch #Chemotherapy #Leukemia #MedicalInnovation #DrugDevelopment
Read Full Article
#CancerResearch #Chemotherapy #Leukemia #MedicalInnovation #DrugDevelopment
ACS Publications
Chemotherapeutic Spherical Nucleic Acids
Herein, we describe experiments showing that liposomal spherical nucleic acid (SNA) constructs comprised of 5-fluorouracil (5-Fu) are selectively taken up by myeloid cells, including acute myeloid leukemia (AML) cells, and act as chemotherapeutics. Specifically…