While the incidence of colorectal cancer is decreasing among those over 50, it is rising at an alarming rate among younger individuals, sometimes as early as their thirties, with no personal or family history. Swiss study reveals an annual increase of 0.5% in people under 50.

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#ColorectalCancer #YoungAdults #CancerResearch

🇨🇭 Switzerland sees a 0.5% annual increase in colorectal cancer among those under 50.

📈 This trend contrasts with a decrease in incidence among older age groups, with cases appearing in people in their thirties.

⚠️ Nearly 28% of patients under 50 are diagnosed with metastatic disease, a challenge compounded by late diagnoses.

#ColorectalCancer #CancerResearch #PublicHealth

🔬 UCalgary study discovers a way to make colorectal cancer visible to immunotherapy by eliminating a single gene.

💉 In mouse models, this gene edit led to 100% tumor eradication when combined with immunotherapy.

💡 The research identifies a protein secreted by resistant tumors that hides them from the immune system, a mechanism that might also apply to other solid tumors like pancreatic and lung cancer.

#CancerResearch #Immunotherapy #ColorectalCancer

Large-scale gut microbiome study identifies robust colorectal cancer signature. The colorectal cancer microbiome signature was linked to lower dietary fibre intake and could be reduced through fibre-focused dietary interventions.

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#GutMicrobiome #ColorectalCancer #DietaryFiber

🔬 Colorectal Cancer Microbiome Signature Identified: Researchers reanalyzed nearly 6,800 gut microbiome profiles, discovering a consistent microbial signature linked to colorectal cancer across diverse populations and study methods.

🧠 AI Can Distinguish Cancer Microbiomes: A machine-learning classifier successfully differentiated between the gut microbiomes of colorectal cancer patients and healthy individuals across multiple datasets.

🥗 Dietary Fibre Influences Signature: The identified colorectal cancer microbiome signature was associated with lower dietary fiber intake and showed a reduction when participants increased fiber consumption.

#GutMicrobiome #ColorectalCancer #HealthTech

Researchers found that 30% (3 of 10) of "harmless" hyperplastic colon polyps actually carry cancer-driving gene mutations like APC and BRAF. DNA profiling of these precancerous growths could help doctors identify high-risk patients and stop colorectal cancer before it starts

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#ColorectalCancer #DNAProfiling #CancerPrevention

🔬 A study analyzed 176 cancer-associated genes in 67 colorectal adenoma (CRA) samples. Putatively pathogenic variants (PPVs) were found in 44 patients, with APC, KRAS, FBXW7, BRAF, and MAP2K4 being the most frequently mutated genes.

📈 Higher frequencies of PPVs were detected in CRA with high-grade dysplasia and tubulo-villous features, suggesting potential for improved risk stratification.

🚨 Even 10 low-risk hyperplastic polyps were analyzed, with three carrying PPVs, including one with mutations in APC, MAP2K4, and FEN1.

💡 Mutational profiling may offer valuable molecular information beyond traditional histopathology for identifying precancerous lesions with higher progression risk.

#ColorectalCancer #CancerResearch #Genetics

Gut Bacteria May Reveal How a Western Diet Fuels Colon Cancer. Certain gut bacteria, sustained by Western-style diets, may produce a substance that promotes tumor growth, finds study in pigs, mice, human colon tissue, and microbial data from thousands of people with and without colorectal cancer.

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#GutHealth #ColorectalCancer #WesternDiet

✅ New study in journal Gut links Western diets to colorectal cancer risk via gut bacteria.

✅ Researchers found a substance called deoxycholic acid (DCA), produced by certain gut bacteria when fed by a Western-style diet (high fat, low fiber), promotes tumor growth and weakens the immune system's ability to fight tumors.

✅ Experiments in pigs, mice, and human tissue showed that reducing bile acids (which bacteria convert to DCA) lessened abnormal cell growth and tumor development.

✅ Analysis of over 2,000 people revealed genes involved in DCA production were more common in those with colorectal cancer, suggesting a direct link.

#ColorectalCancer #GutHealth #CancerResearch

Similar to the US, colorectal cancer has become the leading cause of cancer death among people younger than 50 years in Norway. However, this is not accompanied by increased mortality. Norway has a publicly funded health system and this may contribute to differences in mortality relative to the US.

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#ColorectalCancer #PublicHealthcare #CancerMortalityDecline

A study of 376,511 people followed for up to 14 years found that participation in colorectal cancer screening was associated with a 43% lower risk of dying from the disease, while being invited to screening was associated with a 26% lower risk.

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#ColorectalCancer #ScreeningSaveLives #CancerPrevention

Blood test detects 81% of high-risk colorectal polyps in international study - Research Today

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#ColorectalCancer #MedicalDiagnostics #BloodTestDetection

🔬 An experimental blood test, DENEB, showed promising results in a study of over 1,500 adults, detecting 81% of high-risk precancerous polyps (advanced adenomas) and about 92% of early to mid-stage colorectal cancers.

🔬 The DENEB test analyzes microRNAs in blood, including those within exosomes, to detect molecular changes associated with colorectal abnormalities, aiming to identify precancerous lesions before they become cancer.

🔬 Published this week in The Lancet Gastroenterology & Hepatology, these findings are significant as current blood tests are better at detecting established cancers than these earlier precancerous growths.

🔬 While encouraging, researchers caution that further large-scale studies in diverse screening populations are needed to confirm the test's clinical usefulness, as the validation study included a higher proportion of people with polyps and cancer than typically found in general screenings.

#ColorectalCancer #BloodTest #CancerScreening

Nitrate and nitrite intake and risk of colorectal cancer: a population-based cohort study | JNCI: Journal of the National Cancer Institute | Oxford Academic

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#ColorectalCancer #NitrateNitrite #CancerResearch

Prevalence and chronology of colibactin-associated mutational processes and their microbiome spectra in Japanese colorectal cancer

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#Colibactin #ColorectalCancer #Microbiome

About 466,000 people worldwide developed gastrointestinal cancer before age 50 in 2022, with colorectal cancer being the most common. Higher rates occurred in developed countries. Red-meat-heavy diets and smoking were major linked risk factors, with alcohol and high-salt diets also contributing.

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#ColorectalCancer #GutHealth #CancerPrevention

Engineered Probiotic Wipes Out 43% of Colorectal Tumors in Mice: The engineered E Coli packed a triple-whammy – chemotherapy produced directly inside the tumor, an immune stimulant, and a localized form of immune checkpoint blockade.

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#ProbioticTherapy #ColorectalCancer #SyntheticBiologyTherapy

MIT researchers have identified a cellular pathway controlled by the YAP1 protein that allows colorectal cancer to metastasize, discovering that obesity and high-fat diets can trigger this process through the production of fatty molecules called ceramides.

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#ColorectalCancer #YAP1 #Ceramides

Death rates from lifestyle-linked cancers fell overall in eight high-income countries from 2000 to 2020, but colorectal cancer death rates rose among people born after 1960 in the US, Canada, and England and Wales

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#ColorectalCancer #LifespanTrends #PublicHealthInsights

Large study finds no link between ultra-processed food and colorectal cancer

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#UltraProcessedFood #ColorectalCancer #NutritionScience