MIT researchers have identified a cellular pathway controlled by the YAP1 protein that allows colorectal cancer to metastasize, discovering that obesity and high-fat diets can trigger this process through the production of fatty molecules called ceramides.
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#ColorectalCancer #YAP1 #Ceramides
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#ColorectalCancer #YAP1 #Ceramides
MIT News
Biologists identify a cellular pathway that allows colorectal cancer to metastasize
MIT biologists found that a high-fat diet drives colon cancer cells to switch on YAP1, a regenerative program required for the cancer to spread to the liver. Drugs blocking ceramide production could help prevent metastasis.