Knocking out a gene doesn’t always rob the target cells of their mRNA and protein. Sometimes neighboring cells can provide these basic outputs to, in effect, compensate for the disabled gene. A recent mouse study pinpoints how, at least in fat tissue. 🧬🐭💉
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#GeneKnockout #CellCompensation #mRNA #ProteinSynthesis #MouseStudy
Read Full Article
#GeneKnockout #CellCompensation #mRNA #ProteinSynthesis #MouseStudy
PNAS
In fat tissue, neighbor cells lend a hand when critical genes stop working
Fat cells (in green) can receive mRNA and proteins from neighboring cells. Image Credit: Daeseok Kim, Touchstone Diabetes Center, UT Southwestern Medical Center.
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