Scientists have discovered that some tiny segments of RNA thought to be junk instead have a functional role in suppressing production of certain messenger RNAs and appear to help cells respond to oxidative stress. The segments in question are introns, short sequences of a subset of transfer RNAs.
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#RNAresearch #GeneRegulation #CellBiology #OxidativeStress #IntronsMatter
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#RNAresearch #GeneRegulation #CellBiology #OxidativeStress #IntronsMatter
Ohio State News
‘Junk’ RNA segments play role in protein production, cell stress response
Study is first to show some tRNA introns affect gene expression
Single-cell gene regulation and expression data from 111 human brains 🧠 identified PTSD-associated genes 🧬 and the genetic variants that modulate them 🔍.
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#GeneRegulation #PTSDResearch #SingleCellAnalysis #HumanGenetics #MentalHealthAwareness
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#GeneRegulation #PTSDResearch #SingleCellAnalysis #HumanGenetics #MentalHealthAwareness
Nature
Single-cell transcriptomic and chromatin dynamics of the human brain in PTSD
Nature - A comprehensive analysis of the cell-specific molecular regulatory mechanisms underlying post-traumatic stress disorder in the human prefrontal cortex.
Study shows that removing methyl groups from DNA 🧬 can switch genes back on, confirming that methylation is directly responsible for gene silencing 🔒.
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#GeneRegulation #DNAResearch #Methylation #GeneExpression #Epigenetics
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#GeneRegulation #DNAResearch #Methylation #GeneExpression #Epigenetics
UNSW Sydney
New CRISPR technique could rewrite future of genetic disease treatment
A new study has revealed that chemical tags once regarded as genetic clutter are in fact powerful gene silencers – and removing them could unlock safer treatments for inherited blood disorders.
Scientists discovered a universal physical law governing the chaotic motion of chromosomes inside a living cell 🧬✨. The discovery solves a long-standing biological mystery of how two-meter long DNA molecules remain mobile enough for vital processes like gene regulation 🔍🔬.
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#ChromosomeDynamics #GeneRegulation #ScientificDiscovery #CellBiology #DNAResearch
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#ChromosomeDynamics #GeneRegulation #ScientificDiscovery #CellBiology #DNAResearch
Physical Review Research
Universal center-of-mass scaling shapes segment fluctuations and chromatin dynamics
We show that cancellation of internal forces together with spatially uncorrelated noise generically enforces a universal $1/s$ scaling of the center-of-mass (COM) diffusivity for polymer segments of contour length $s$, independent of model details. Within…
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