Objective To determine the efficacy of psilocybin as an antidepressant compared with placebo or non-psychoactive drugs.

Design Systematic review and meta-analysis.

Data sources Five electronic databases of published literature (Cochrane Central Register…

Objective:Evidence suggests that psilocybin-assisted therapy (PAT) leads to durable shifts in
personality structure. However, such changes have yet to be characterized in disorders
of addiction. In this secondary analysis from a randomized controlled ...

Does psilocybin affect everyone the same way? New research suggests that race and ethnicity may play a role in the long-term benefits of this psychedelic substance.

Nature Neuroscience - Hammo et al. show that a single dose of psilocybin rapidly and sustainably relieves both chronic pain and anxiodepressive-like behaviors in mice by restoring prefrontal...

Chronic microdosing of psilocybin could fight obesity and diabetes without the "trip." Researchers discovered that non-hallucinogenic doses reduced weight gain and restored insulin sensitivity in mice by targeting specific receptors in the liver.

Published in Scientific Reports, new research provides evidence that minor compounds in psychedelic mushrooms work alongside psilocybin to interact with brain receptors. This chemical teamwork explains why whole mushroom extracts often affect people differently…

Clinical trials show psilocybin provides rapid relief for depression, but the underlying biology remains unclear. New research demonstrates how varying doses of the drug bind to serotonin receptors to enhance cellular flexibility.

A recent trial involving healthy volunteers demonstrates that a single dose of psilocybin can prompt lasting changes in personal values, increasing self-acceptance and appreciation for life through acute feelings of spiritual euphoria and profound unity.

Participants took 25mg of psilocybin, reporting deeper psychological insight and better wellbeing a month later

A single dose of psilocybin — the active compound in magic mushrooms — reduces nerve pain for up to a month and makes a widely used painkiller work more effectively, University of Reading research has found.