Autism related hyperexcitability was transferred to healthy neurons by extracellular vesicles from mutant cells in a SHANK3 model, whereas stem cell derived vesicles rescued hyperexcitability, normalized maturation, and improved behavior in mice.
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#AutismResearch #SHANK3 #ExtracellularVesicles #NeuralMaturation #TherapeuticStemCells
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#AutismResearch #SHANK3 #ExtracellularVesicles #NeuralMaturation #TherapeuticStemCells
Nature
Extracellular vesicles from stem cells rescue cellular phenotypes and behavioral deficits in SHANK3-associated ASD neuronal and…
Cell Death & Disease - Extracellular vesicles from stem cells rescue cellular phenotypes and behavioral deficits in SHANK3-associated ASD neuronal and mouse models