Deep mutational scanning of H5 hemagglutinin to inform influenza virus surveillance. A mutation present in some recent H5 HAs causes a large antigenic change.
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#DeepMutationalScanning #InfluenzaSurveillance #H5Hemagglutinin #ViralEvolution #AntigenicChange
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#DeepMutationalScanning #InfluenzaSurveillance #H5Hemagglutinin #ViralEvolution #AntigenicChange
journals.plos.org
Deep mutational scanning of H5 hemagglutinin to inform influenza virus surveillance
H5 influenza is considered a potential pandemic threat. Using deep mutational scanning, this work reveals how the >10,000 different possible amino-acid mutations in hemagglutinin affect cell entry, receptor preference, protein stability and neutralization…
When bacteriophages reached the International Space Station, microbes behaved unlike on Earth 🚀🪐🧬.
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#SpacePhage #MicrogravityScience #PhageTherapy #SpaceBiology #ViralEvolution
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#SpacePhage #MicrogravityScience #PhageTherapy #SpaceBiology #ViralEvolution
journals.plos.org
Microgravity reshapes bacteriophage–host coevolution aboard the International Space Station
Phage-host interactions have a role shaping microbial ecosystems, but their behavior in microgravity remains largely unexplored. In this study, experiments aboard the ISS reveal distinct evolutionary adaptations in T7 bacteriophage and E. coli, revealing…
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Science News
Recent pandemic viruses jumped to humans without prior adaptation. No evidence that SARS-CoV-2 was shaped by selection in a laboratory: UCSD study. Read Full Article #pandemicnews #virology #SARSCoV2 #publichealth #UCSDstudy
🔬 Most pandemic viruses jump to humans "as is", without evolving special adaptations first. A UC San Diego study analyzed genomes of viruses like SARS-CoV-2, influenza, and Ebola, finding no evidence of pre-adaptation for human infection before outbreaks.
🔬 SARS-CoV-2 shows no lab adaptation signals. The study found its evolutionary pattern aligns with natural circulation in animals, challenging theories of prolonged laboratory manipulation.
🔬 The 1977 H1N1 flu is a rare exception. This strain exhibits genetic signatures consistent with laboratory passage, supporting the idea of an accidental lab-linked reemergence.
#PandemicOrigins #ViralEvolution #PublicHealth
🔬 SARS-CoV-2 shows no lab adaptation signals. The study found its evolutionary pattern aligns with natural circulation in animals, challenging theories of prolonged laboratory manipulation.
🔬 The 1977 H1N1 flu is a rare exception. This strain exhibits genetic signatures consistent with laboratory passage, supporting the idea of an accidental lab-linked reemergence.
#PandemicOrigins #ViralEvolution #PublicHealth
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Scientists Discover Human Brain Gene BC200 Embedded in a Poxvirus, Revealing That a Functional Gene Involved in Neuronal Activity Has Retained the Ability to “Jump” Between Genomes—A Genetic Combination Never Before Observed
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# Neuroscience #Genomics #ViralEvolution
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# Neuroscience #Genomics #ViralEvolution
ScienceAlert
DNA From a Human Brain Gene Has Turned Up In a Virus
A surprising leap across genomes.
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