Genomics reveals sled dogs’ Siberian lineage: Research finds sled dogs descended from two distinct lineages of Arctic canids and originated in the northeastern Siberian Arctic generations earlier than previously thought

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#Genomics #SledDogs #SiberianLineage #ArcticCanids #NortheasternSiberia

DNA remnants in red blood cells enable early detection of cancer 🩸🔬✨

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#DNAdetection #cancerdetection #earlydiagnosis #redbloodcells #genomics

New antibody-drug bexmarilimab can activate the body's defense system against cancer. This activation occurs especially when the tumor microenvironment is immunologically silent. Researchers also discovered that patients who benefit from the drug can be identified by measuring their gene signature. 🧬💉✨

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#cancerresearch #immunotherapy #bexmarilimab #genomics #tumormicroenvironment

Huge genetic study reveals hidden links between psychiatric conditions 🧬🧠. A genomic analysis of more than one million people suggests that most major psychiatric conditions have common biological roots.

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#GeneticResearch #PsychiatricHealth #MentalHealthAwareness #Genomics #PublicHealth

Scientists uncover key driver of treatment-resistant cancer: 🧬 « UC San Diego scientists discover enzyme responsible for scrambling cancer genomes; results could enable new treatments for the most aggressive cancers. 💊🔬 »

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#CancerResearch #TreatmentResistance #Genomics #CancerTreatment #UCSanDiego

Scientists sequence a woolly rhino genome from a 14,400-year-old wolf’s stomach 🐺🦏 | Genome Shows no Recent Inbreeding in Near-Extinction Woolly Rhinoceros Sample Found in Ancient Wolf's Stomach 🧬🦏

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#WoollyRhinoceros #AncientDNA #Genomics #Paleontology #WildlifeConservation

Genetic 🧬 relationships between the gut microbiota 🦠 and prostate cancer: Mendelian 🧬 randomization 🔬 combined with bioinformatics analysis 💡

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#GutMicrobiota #ProstateCancer #MendelianRandomization #Bioinformatics #Genomics

🧬 Evo 2, an open-source AI, has been trained on genomes from bacteria, archaea, and eukaryotes, processing trillions of DNA base pairs.

🧠 This advanced AI can now identify key features in complex genomes, such as regulatory DNA and splice sites, which are difficult for humans to locate.

#AI #Genomics #BioTech

💧 Scientists have identified unique genetic adaptations in the Turkana people of Kenya that allow them to conserve water and process high-protein diets in their arid environment.

⚖️ These ancient adaptations, while beneficial for survival in the desert, are now causing health issues like diabetes and hypertension as Turkana individuals move to urban settings with different lifestyles and diets.

🔬 Genomic sequencing of 367 Turkana individuals revealed a specific gene, STC1, which helps their kidneys retain water and filter waste from protein-rich foods.

#Genomics #HumanAdaptation #HealthResearch

A team of scientists from Manchester and London have, for the first time, decoded the full range of mutations that drive tumour growth, which could pave the way for a new era in precision medicine, offering more effective treatments for thousands of people with cancer.

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#CancerResearch #PrecisionMedicine #Genomics

🔬 UK scientists have mapped 370 million genetic mutations across 16 cancer types, identifying 134 "mutational signatures" that act like fingerprints of cancer causes.

🧬 This groundbreaking research, published in Nature Genetics, analyzed nearly 11,000 NHS patient tumors and could expand eligibility for precision therapies, potentially helping over 7,700 UK breast cancer patients and 1,000 ovarian cancer patients with homologous recombination deficiency (HRD).

🦠 The study also found evidence supporting the theory that toxins from certain E. coli strains may contribute to early-onset bowel cancer, as the associated signature was more prevalent in younger patients.

#CancerResearch #Genomics #PrecisionMedicine

Rare lung cancers can "change identity" to evade treatment, according to a spatial genomics study. Researchers found these tumors evolve from a single cell into hybrid states and create immune-shielded zones, suggesting the disease is widely underdiagnosed.

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#LungCancer #CancerResearch #Genomics

Large-scale analysis of 15,836 ancient West Eurasians detects consistent trends in allele frequency change, showing many hundreds of alleles under strong directional selection the past 10,000 years, including variants that today predict complex traits such as body fat, schizophrenia, and cognition.

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#Genomics #PopulationGenetics #GWAS

In a biggest study of it's kind (693,869 people), it identified 74 locations in the genome where genetic differences were linked to anxiety symptoms. Around half of these have been reported in previous  anxiety genome wide association studies, but the remainder (39 of the loci) were novel.

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#Genomics #AnxietyResearch # GWAS novelties

A genome-scale CRISPRi perturbation atlas of human induced pluripotent stem cells | Nature Biotechnology

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#CRISPR #iPSC #Genomics

Everyone alive may carry DNA from a ‘ghost lineage’ of human ancestors. In a new study, scientists read the family tree buried inside modern genomes and turned up “ghost ancestors” in every population on Earth that no fossil records can account for

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#Genomics #GhostAncestors #HumanEvolution

Scientists Discover Human Brain Gene BC200 Embedded in a Poxvirus, Revealing That a Functional Gene Involved in Neuronal Activity Has Retained the Ability to “Jump” Between Genomes—A Genetic Combination Never Before Observed

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# Neuroscience #Genomics #ViralEvolution