🔬 Exciting News from Our Recent Paper! 🔬

📚 Title: In silico study of the impact of oxidation on pyruvate transmission across the hVDAC1 protein channel

Our recently published paper delves into the fascinating realm of cancer cell metabolism, focusing on the pivotal role of Voltage Dependent Anion Channels (VDACs), particularly VDAC1. Here's a snapshot of our findings:

🔍 Objective: Investigating the Effect of Low-Level VDAC1 Oxidation on Pyruvate Uptake

🧪 Methodology: Leveraging Molecular Dynamics (MD) Simulations

👉 Key Insights:
The overexpression of VDACs, especially VDAC1, in cancer cells compared to normal cells, has long been recognized. In our study, we honed in on the impact of a low level of VDAC1 oxidation, induced by Cold Atmospheric Plasma (CAP), on pyruvate (Pyr) uptake. Inhibiting Pyr uptake through VDAC1 emerges as a potential strategy to suppress cancer cell proliferation.

💡 Significant Findings:

Employed MD simulations to analyze hVDAC1 structure with modified cysteine and methionine residues.
Results indicated that the free energy barrier for Pyr translocation through the oxidized channel was significantly higher compared to the native channel.
Specifically, the barrier for Pyr translocation through the native channel was approximately 4.3 ± 0.7 kJ mol−1, while for the oxidized channel, it rose to 10.8 ± 1.8 kJ mol−1.
Higher barrier in the oxidized channel correlates with a decreased rate of Pyr permeation, suggesting a potential mechanism for inhibiting cancer cell proliferation.
🌐 Broader Implications:
Our findings unveil that low levels of CAP-induced oxidation reduce Pyr translocation, thereby curbing cancer cell proliferation. This suggests that subtle oxidative modifications may hold therapeutic potential in treating cancer cells by disrupting crucial metabolic pathways.

🚀 Future Directions:
Our research lays the groundwork for further exploration of CAP-induced oxidation as a targeted approach in cancer treatment. As we unravel the intricate connections between VDAC1, Pyr uptake, and cancer cell metabolism, we pave the way for innovative strategies in the fight against cancer.

🙌 Acknowledgments:
Kudos to our dedicated team for their commitment to advancing scientific knowledge and contributing to the ongoing discourse in cancer research. Together, we are shaping the future of cancer treatment!

#CancerResearch #ScienceBreakthrough #MolecularDynamics #ColdPlasma #InnovationInHealthcare #ResearchPublication

I am absolutely thrilled to share another significant achievement from our research team! 🎉

Thanks to the relentless hard work and dedication of my student, our young scientist Dr. Davronjon Abduvokhidov (who recently earned his PhD), our latest article has been officially published in Scientific Reports, a prestigious journal by the Nature Portfolio.

🔬 Article: Selective Transport of Plasma-Derived Reactive Species through the Plant Aquaporin Channels: A Molecular Dynamics Study

In this research, we used high-precision molecular dynamics (MD) simulations to investigate the interaction of cold atmospheric plasma with plant cell membranes, specifically focusing on the transport mechanisms of reactive species through aquaporin channels. The insights gained from this study provide a crucial foundation for the safer and more effective application of plasma technologies in agriculture and biomedicine.

I would like to express my deep gratitude to our international collaborator, Dr. Parthiban Marimuthu from Åbo Akademi University (Finland), for his invaluable contribution to the successful completion of this project. Special thanks also go to our co-authors, Akbar and Muhammadali, for their active participation and valuable input throughout the research process.

My sincere congratulations to the lead author, Dr. Davronjon, and our entire team on this major publication! May your passion for science, your drive for continuous research, and your dedication never fade. Wishing you the best of luck as we move toward our next goals and new horizons! 🚀

You can read the full article via the link below:
🔗 [https://www.nature.com/articles/s41598-026-61939-z](https://www.nature.com/articles/s41598-026-61939-z)

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Katta quvonch bilan jamoamizning navbatdagi muhim yutug'ini sizlar bilan baham ko'rmoqchiman! 🎉

Iqtidorli shogirdim, yaqindagina PhD ilmiy darajasini muvaffaqiyatli himoya qilgan yosh olimimiz Davronjon Abduvokhidovning tinimsiz mehnati va izlanishlari natijasida tayyorlangan maqolamiz nufuzli Nature Portfolio nashriyotiga qarashli Scientific Reports jurnalida rasman chop etildi.

🔬 Maqola: Selective Transport of Plasma-Derived Reactive Species through the Plant Aquaporin Channels: A Molecular Dynamics Study

Ushbu tadqiqot doirasida biz sovuq atmosferik plazmaning o'simlik hujayra membranalari bilan o'zaro ta'sirini, xususan, reaktiv zarrachalarning akvaporin kanallari orqali tashilish mexanizmlarini molekulyar dinamika (MD) usulida yuqori aniqlikda o'rganib chiqdik. Olingan natijalar plazma texnologiyalarini qishloq xo'jaligi va biotibbiyotda yanada xavfsiz hamda samarali qo'llash uchun muhim poydevor bo'lib xizmat qiladi.

Shu o'rinda loyihamizni muvaffaqiyatli yakunlashda o'zining katta hissasini qo'shgan xalqaro hamkorimiz — Finlyandiyaning Åbo Akademi universiteti tadqiqotchisi Dr. Parthiban Marimuthuga va tadqiqot jarayonlarida faol ishtirok etib, o'zining qimmatli hissalarini qo'shgan hammualliflarimiz Akbar va Muhammadaliga alohida minnatdorchiligimni bildiraman.

Maqolaning bosh muallifi, yosh olimimiz Dr. Davronjonni va butun jamoamizni ushbu yirik nashr bilan chin dildan tabriklayman! Ilm-fan yo'lidagi shijoatingiz, o'z ustingizda ishlashdan to'xtamasligingiz va izlanuvchanligingiz hech qachon so'nmasin. Keyingi maqsadlar va yangi marralar sari omad tilayman! 🚀

Maqolaning to'liq matni bilan quyidagi havola orqali tanishishingiz mumkin:
🔗 [https://www.nature.com/articles/s41598-026-61939-z](https://www.nature.com/articles/s41598-026-61939-z)

#Nature #ScientificReports #ComputationalChemistry #MolecularDynamics #ColdPlasma #Science #Uzbekistan #Research #TeamWork