Woman With 3 Autoimmune Diseases Enters Remission After Immune 'Reset'. Chimeric Antigen Receptor (CAR-) T cell therapy, which involves extracting a sample of immune cells, 'supercharging' them against a specific target, and returning them to the body.
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#CAR-Ttherapy #AutoimmuneDiseases #ImmunotherapyResearch
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#CAR-Ttherapy #AutoimmuneDiseases #ImmunotherapyResearch
the Guardian
Woman with three deadly diseases has ‘remarkable’ recovery after cell therapy
Treatment reset wayward immune system of patient with life-threatening conditions, say scientists, in a world first
Gene edits known as base editing could solve obstacles to treating solid tumor cancers, such as lung, breast and kidney cancers, with CAR-T cell therapy, researchers find.
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#BaseEditing #CAR-TcellTherapy #SolidTumorCancers
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#BaseEditing #CAR-TcellTherapy #SolidTumorCancers
Northeastern Global News
Designing a better treatment for solid tumor cancers that works ‘off-the-shelf’
New research shows how to remove obstacles to solid tumor cancer treatments with genetic engineering.
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A next-generation CAR T-cell therapy successfully eliminates glioblastoma brain tumors in preclinical trials. The treatment targets a protein called uPAR, destroying both the deadly cancer cells and the supportive infrastructure that fuels them.
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#CAR T #glioblastoma #uPARtherapy
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#CAR T #glioblastoma #uPARtherapy
Science Translational Medicine
uPAR is highly expressed in recurrent glioblastoma and represents a candidate CAR T cell target
The urokinase receptor uPAR is highly expressed in recurrent glioblastoma and is targetable using anti-uPAR chimeric antigen receptor T cells.
USC scientists just unlocked an endless supply of cancer-fighting immune cells Scientists have turned an overlooked immune-cell precursor into a renewable, engineerable weapon against cancer and disease.
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#CancerImmunotherapy #CAR-T #CancerResearch
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#CancerImmunotherapy #CAR-T #CancerResearch
Cell
Expansion and CAR engineering of granulocyte-monocyte progenitors for cellular immunotherapy
This study establishes granulocyte-monocyte progenitors as a renewable upstream platform
for engineered myeloid cell therapy and introduces a CAR-Fc strategy that couples
direct tumor targeting to host antigen-presenting cell activation.
for engineered myeloid cell therapy and introduces a CAR-Fc strategy that couples
direct tumor targeting to host antigen-presenting cell activation.
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A 3-Year-Old's Metastatic Cancer Disappeared After Two Doses of Experimental Therapy: Complete regression of hepatoblastoma, a malignant liver cancer and chemotherapy-resistant solid tumor, after CAR T cell treatment, achieved entirely in the outpatient setting without systemic toxicity.
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#CAR-T #PediatricCancer #Hepatoblastoma
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#CAR-T #PediatricCancer #Hepatoblastoma
ScienceAlert
A 3-Year-Old's Metastatic Cancer Disappeared After Two Doses of Experimental Therapy
This could save lives.
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